ATE309993T1 - 4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten - Google Patents

4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten

Info

Publication number
ATE309993T1
ATE309993T1 AT98914096T AT98914096T ATE309993T1 AT E309993 T1 ATE309993 T1 AT E309993T1 AT 98914096 T AT98914096 T AT 98914096T AT 98914096 T AT98914096 T AT 98914096T AT E309993 T1 ATE309993 T1 AT E309993T1
Authority
AT
Austria
Prior art keywords
optionally substituted
custom
ring
hydrocarbon group
bond
Prior art date
Application number
AT98914096T
Other languages
English (en)
Inventor
Hiroshi Mabuchi
Nobuhiro Suzuki
Takashi Miki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE309993T1 publication Critical patent/ATE309993T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98914096T 1997-04-21 1998-04-20 4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten ATE309993T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10313897 1997-04-21
JP31954597 1997-11-20
PCT/JP1998/001797 WO1998047882A1 (en) 1997-04-21 1998-04-20 4,1-benzoxazepines, their analogues, and their use as somatostatin agonists

Publications (1)

Publication Number Publication Date
ATE309993T1 true ATE309993T1 (de) 2005-12-15

Family

ID=26443792

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98914096T ATE309993T1 (de) 1997-04-21 1998-04-20 4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten

Country Status (9)

Country Link
US (1) US6352982B1 (de)
EP (1) EP0979227B1 (de)
KR (1) KR20010012072A (de)
CN (1) CN1252795A (de)
AT (1) ATE309993T1 (de)
AU (1) AU6854598A (de)
CA (1) CA2285664A1 (de)
DE (1) DE69832376T2 (de)
WO (1) WO1998047882A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2327695A1 (en) 1998-04-08 1999-10-21 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
US20010012620A1 (en) * 1998-06-03 2001-08-09 Rich Ivan N. Method of reducing cell proliferation by inducing apoptosis in differentially selected cell subpopulations
CA2348159A1 (en) 1998-10-20 2000-04-27 Satoru Oi Aromatic amine derivatives, their production and use
US7091247B2 (en) 2000-06-28 2006-08-15 Takeda Pharmaceutical Company Limited Biphenyl compound
CA2451163A1 (en) * 2001-06-28 2003-01-09 Takeda Chemical Industries, Ltd. Agent for preventing or treating organ functional disorders and order dysfunction
WO2003011276A1 (fr) * 2001-07-26 2003-02-13 M's Science Corporation Inhibiteur nf$g(k)b
US7189856B2 (en) * 2001-12-28 2007-03-13 Gideon Shapiro Non-peptide somatostatin receptor ligands
AU2003286755A1 (en) * 2002-10-30 2004-06-07 Smithkline Beecham Corporation Benzodiazepine derivatives for the treatment of diabetes mellitus
WO2004067008A1 (ja) * 2003-01-28 2004-08-12 Takeda Pharmaceutical Company Limited 受容体作動薬
US20070129348A1 (en) * 2003-04-18 2007-06-07 Fumio Itoh Receptor antagonist
FI20031454A0 (fi) 2003-10-06 2003-10-06 Juvantia Pharma Ltd Oy Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja
CA2609161A1 (en) * 2005-05-18 2006-11-23 Siegfried Wurster Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4
WO2008141081A1 (en) * 2007-05-10 2008-11-20 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US20110136788A1 (en) * 2008-08-07 2011-06-09 Minoru Maruyama Therapeutic agent for irritable bowel syndrome
WO2016075239A1 (en) * 2014-11-14 2016-05-19 Boehringer Ingelheim International Gmbh Aryl and heteroaryl-fused tetrahydro-1,4-oxazepine amides as somatostatin receptor subtype 4 (sstr4) agonists
JP7099717B2 (ja) 2019-09-30 2022-07-12 株式会社理研バイオ ソマトスタチン受容体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458501A (en) 1967-02-09 1969-07-29 American Home Prod 5-(m-sulfamoylphenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one
JPS5735576A (en) 1980-07-18 1982-02-26 Takeda Chem Ind Ltd 4,1-benzoxazepin-3-acetic derivative and its production
US5593988A (en) 1991-10-11 1997-01-14 Yoshitomi Pharmaceutical Industries, Ltd. Therapeutic agent for osteoporosis and diazepine compound
US5428031A (en) 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
SG82630A1 (en) 1992-04-20 2001-08-21 Takeda Chemical Industries Ltd 4,1-benzoxazepin derivatives and their use
AU678503B2 (en) 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
JP3257731B2 (ja) 1993-09-29 2002-02-18 塩野義製薬株式会社 抗潰瘍活性を有するベンゾジアゼピン誘導体
WO1996009827A2 (en) 1994-09-20 1996-04-04 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
TW401301B (en) 1994-10-07 2000-08-11 Takeda Chemical Industries Ltd Antihypertriglyceridemic composition
JPH08259447A (ja) 1995-03-24 1996-10-08 Takeda Chem Ind Ltd コレシストキニン拮抗剤
FR2733984B1 (fr) 1995-05-10 1997-07-04 Rhone Poulenc Rorer Sa Derives de tryptamine, leur preparation et les medicaments les contenant
EP0862562B1 (de) 1995-09-13 2001-07-04 Takeda Chemical Industries, Ltd. Benzoxazepinverbindungen, ihre herstellung und verwendung als lipidsenker
WO1998000406A1 (en) 1996-07-02 1998-01-08 Merck & Co., Inc. Method for the treatment of preterm labor

Also Published As

Publication number Publication date
CA2285664A1 (en) 1998-10-29
EP0979227A1 (de) 2000-02-16
DE69832376T2 (de) 2006-08-03
CN1252795A (zh) 2000-05-10
DE69832376D1 (de) 2005-12-22
US6352982B1 (en) 2002-03-05
EP0979227B1 (de) 2005-11-16
KR20010012072A (ko) 2001-02-15
WO1998047882A1 (en) 1998-10-29
AU6854598A (en) 1998-11-13

Similar Documents

Publication Publication Date Title
ATE309993T1 (de) 4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten
ID21538A (id) Turunan anilida, produksi dan pemakaiannya
IL150651A0 (en) Nitrogen-containing cyclic compound and pharmaceutical compositions containing the same
ATE277012T1 (de) Piperidin- und pyrrolidin-derivate enthaltend ein stickstoffoxid donor zur behandlung von stress
CA2167673A1 (en) Condensed benzazepine derivative and pharmaceutical composition thereof
MXPA02012314A (es) Compuestos de 1,2-dihidropiridina, metodo de fabricacion y utilizacion de los mismos.
ATE390404T1 (de) Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta
IL126610A0 (en) N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3- one derivatives as factor xa inhibitors
EP1285651A4 (de) Antagonisten des melanin-konzentrierenden hormons
ES2189968T3 (es) Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS.
AP2003002841A0 (en) Quinazolines as MMP-13 inhibitors
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
ATE304523T1 (de) Trisubstituierte-n-((1s)-1,2,3,4-tetrahydro-1- naphthalenyl) benzamide welche p2x3 und p2x2/3 enthaltende rezeptoren inhibieren
NO953270L (no) Fibrinogenreceptorantagonister
DE60224535D1 (de) Unsymmetrische zyklische diaminverbindung
ES2126693T3 (es) Derivado de triazina, su produccion y su uso.
DE69328549D1 (de) Für einen humanen serotoninrezeptor (5-ht4b) kodierende dns und ihre verwendung
AP2000002008A0 (en) Tetrahydroquinoline derivatives as glycine antagonists.
DK0888379T3 (da) Forbindelser tilhørende amidinium-familien, farmaceutiske præparater indeholdende disse forbindelser og anvendelsen deraf
BR0207966A (pt) Composição farmacêutica contendo derivados 1,3-tiazina
NO994135L (no) Kinoksalindioner
BG101000A (en) Formulaminophenylsulphonyl ureas, methods of oreparing them and their use as herbicides and plant-growth regulators
DE69430766T2 (de) Vasculäre Hypertrophicsuppressor
YU41702A (sh) Nitro-sulfobenzamidi
DE69521895T2 (de) Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties