EA200000731A1 - Альфа-аминоамидные производные, полезные в качестве анальгетических агентов - Google Patents
Альфа-аминоамидные производные, полезные в качестве анальгетических агентовInfo
- Publication number
- EA200000731A1 EA200000731A1 EA200000731A EA200000731A EA200000731A1 EA 200000731 A1 EA200000731 A1 EA 200000731A1 EA 200000731 A EA200000731 A EA 200000731A EA 200000731 A EA200000731 A EA 200000731A EA 200000731 A1 EA200000731 A1 EA 200000731A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrogen
- alpha
- integer
- alkyl
- aminoamid
- Prior art date
Links
- 239000000730 antalgic agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
Abstract
Описывается применение в производстве лекарственного средства для применения в качестве анальгетика соединения, которое представляет альфа-аминоамид формулы (I), в которой A представляет группу -(CH)-, -(CH)-X- или -(CH)-O-, где m является целым числом от 1 до 4, n равно нулю или целому числу от 1 до 4, X представляет -S- или -NH-, a v равно нулю или целому числу от 1 до 5; s равно 1 или 2; R представляет фурильное, тиенильное или пиридильное кольцо или фенильное кольцо; Rпредставляет водород или C-Cалкил; один из Rи Rпредставляет водород, а другой представляет водород или C-Cалкил, необязательно замещенный гидрокси или фенилом; или Rи R, взятые вместе с атомом углерода, с которым они связаны, образуют C-Cциклоалкильное кольцо; или Rи Rоба представляют метил; Rпредставляет водород или C-Cалкильную группу; или его фармацевтически приемлемой соли.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9727523.4A GB9727523D0 (en) | 1997-12-31 | 1997-12-31 | Alpha-aminoamide derivatives useful as analgesic agents |
PCT/EP1998/008157 WO1999035125A1 (en) | 1997-12-31 | 1998-12-12 | Alpha-aminoamide derivatives useful as analgesic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200000731A1 true EA200000731A1 (ru) | 2001-02-26 |
EA002763B1 EA002763B1 (ru) | 2002-08-29 |
Family
ID=10824342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000731A EA002763B1 (ru) | 1997-12-31 | 1998-12-12 | Альфа-аминоамидные производные, полезные в качестве анальгетических агентов |
Country Status (19)
Country | Link |
---|---|
US (2) | USRE40259E1 (ru) |
EP (1) | EP1045830B1 (ru) |
JP (1) | JP4410930B2 (ru) |
KR (1) | KR100525587B1 (ru) |
AT (1) | ATE238273T1 (ru) |
BR (1) | BR9814548A (ru) |
CA (1) | CA2316902C (ru) |
DE (1) | DE69813896T2 (ru) |
DK (1) | DK1045830T3 (ru) |
EA (1) | EA002763B1 (ru) |
ES (1) | ES2194392T3 (ru) |
GB (1) | GB9727523D0 (ru) |
HK (1) | HK1028020A1 (ru) |
HU (1) | HU228995B1 (ru) |
IL (2) | IL136734A0 (ru) |
NO (1) | NO327453B1 (ru) |
NZ (1) | NZ505440A (ru) |
PT (1) | PT1045830E (ru) |
WO (1) | WO1999035125A1 (ru) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2402104T3 (es) * | 1997-11-21 | 2013-04-29 | Purdue Neuroscience Company | Uso de 2-aminoacetamidas sustituidas para el tratamiento o alivio de la ansiedad |
CA2430151A1 (en) * | 2000-11-27 | 2002-06-20 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
PT1423168E (pt) | 2001-09-03 | 2006-05-31 | Newron Pharm Spa | Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico |
US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
WO2004087125A1 (en) * | 2003-04-02 | 2004-10-14 | Ionix Pharmaceuticals Limited | Amino acid derivatives as inhibitors of mammalian sodium channels |
AR044007A1 (es) | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
WO2005000309A2 (en) * | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
DE602004025586D1 (de) * | 2003-08-25 | 2010-04-01 | Newron Pharm Spa | Alpha-aminoamid derivate zur verwendung als anti-inflammatorische wirkstoffe |
EP1524267A1 (en) * | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Substituted benzylaminoalkylene heterocycles |
EP1533298A1 (en) * | 2003-11-21 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | 3-aminopyrrolidone derivatives |
EP1533302A1 (en) * | 2003-11-21 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | Histidine derivatives |
EP1535908A1 (en) | 2003-11-24 | 2005-06-01 | Newron Pharmaceuticals S.p.A. | N-acyl-N'-benzyl-alkylendiamino drivatives |
EP1533295A1 (en) * | 2003-11-24 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | Cyclopentyl Derivatives |
EP1557166A1 (en) * | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
EP1588704A1 (en) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
ES2347581T3 (es) * | 2004-09-10 | 2010-11-02 | Newron Pharmaceuticals S.P.A. | Uso de (r)-(halobenciloxi)bencilamino-propanamidas como moduladores selectivos del canal de sodio y/o calcio. |
TW200730494A (en) | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
TW200728258A (en) * | 2005-10-10 | 2007-08-01 | Glaxo Group Ltd | Novel compounds |
JP5139307B2 (ja) * | 2005-10-10 | 2013-02-06 | グラクソ グループ リミテッド | ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体 |
AU2006329040C1 (en) * | 2005-12-22 | 2011-12-08 | Newron Pharmaceuticals S.P.A. | 2 -Phenylethylamino derivatives as calcium and/or sodium channel modulators |
EP1870097A1 (en) * | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of cognitive disorders |
NZ572798A (en) | 2006-06-19 | 2011-11-25 | Newron Pharm Spa | Process for the production of safinamide and ralfinamide |
CN101687773B (zh) | 2007-06-15 | 2014-07-30 | 纽朗制药有限公司 | 取代的2-[2-(苯基)乙氨基]烷酰胺衍生物及其作为钠和/或钙通道调节剂的应用 |
EP2229351B1 (en) | 2007-12-11 | 2017-11-08 | Newron Pharmaceuticals S.p.A. | Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree |
EP2314569A1 (en) | 2009-10-22 | 2011-04-27 | Merck Patent GmbH | Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof |
PT2563355T (pt) | 2010-04-27 | 2016-09-02 | Newron Pharm Spa | Processo para a produção de sais metanossulfonato de ralfinamida ou dos seus enantiómeros r |
KR20150054795A (ko) | 2012-09-10 | 2015-05-20 | 에프. 호프만-라 로슈 아게 | B형 간염 바이러스 감염의 치료 및 예방을 위한 6-아미노산 헤테로아릴다이하이드로피리미딘 |
WO2015102390A1 (ko) * | 2013-12-30 | 2015-07-09 | 이화여자대학교 산학협력단 | 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물 |
ES2912881T3 (es) | 2014-12-23 | 2022-05-30 | Convergence Pharmaceuticals | Procedimiento para preparar derivados de alfa-carboxamida pirrolidina |
CN107522654B (zh) * | 2016-06-21 | 2020-09-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的α-氨基酰胺衍生物及其医药用途 |
AU2018346763A1 (en) | 2017-10-05 | 2020-04-16 | Biogen Inc. | Process for preparing alpha-carboxamide pyrolidine derivatives |
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DE3050800C2 (ru) | 1979-03-22 | 1989-06-22 | Continental Pharma Inc., Bruessel/Bruxelles, Be | |
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ZA805476B (en) | 1979-09-26 | 1981-11-25 | Robins Co Inc A H | 2-amino-3-benzoyl-phenylacetamides and cyclic homologues |
FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
EP0144853B1 (en) | 1983-11-21 | 1990-09-26 | Fujisawa Pharmaceutical Co., Ltd. | Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same |
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US5153226A (en) | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
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US5541204A (en) | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
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US5849737A (en) | 1995-04-14 | 1998-12-15 | The Regents Of The University Of California | Compositions and methods for treating pain |
US5741818A (en) | 1995-06-07 | 1998-04-21 | University Of Saskatchewan | Semicarbazones having CNS activity and pharmaceutical preparations containing same |
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GB9515411D0 (en) | 1995-07-27 | 1995-09-27 | Pharmacia Spa | N-(4-substituted-benzyl)-2-aminolactam derivatives |
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TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
GB9706730D0 (en) | 1997-04-03 | 1997-05-21 | Pharmacia & Upjohn Spa | 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives |
KR20010020201A (ko) | 1997-04-22 | 2001-03-15 | 코센시스 인크 | 탄소고리 및 헤테로고리 치환된 세미카르바존 및 티오세미카르바존과 그들의 사용 방법 |
ES2402104T3 (es) | 1997-11-21 | 2013-04-29 | Purdue Neuroscience Company | Uso de 2-aminoacetamidas sustituidas para el tratamiento o alivio de la ansiedad |
GB9727521D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Substituted 2-benzylamino-2-phenyl-acetamide compounds |
CA2319484A1 (en) | 1998-02-04 | 1999-08-12 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
US6281211B1 (en) | 1999-02-04 | 2001-08-28 | Euro-Celtique S.A. | Substituted semicarbazides and the use thereof |
PT1423168E (pt) | 2001-09-03 | 2006-05-31 | Newron Pharm Spa | Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico |
EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
AR044007A1 (es) | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
EP1588704A1 (en) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
-
1997
- 1997-12-31 GB GBGB9727523.4A patent/GB9727523D0/en not_active Ceased
-
1998
- 1998-12-12 BR BR9814548-7A patent/BR9814548A/pt not_active Application Discontinuation
- 1998-12-12 HU HU0100870A patent/HU228995B1/hu unknown
- 1998-12-12 ES ES98966617T patent/ES2194392T3/es not_active Expired - Lifetime
- 1998-12-12 KR KR10-2000-7007229A patent/KR100525587B1/ko not_active IP Right Cessation
- 1998-12-12 EA EA200000731A patent/EA002763B1/ru not_active IP Right Cessation
- 1998-12-12 CA CA002316902A patent/CA2316902C/en not_active Expired - Lifetime
- 1998-12-12 JP JP2000527527A patent/JP4410930B2/ja not_active Expired - Lifetime
- 1998-12-12 US US11/359,982 patent/USRE40259E1/en not_active Expired - Lifetime
- 1998-12-12 PT PT98966617T patent/PT1045830E/pt unknown
- 1998-12-12 AT AT98966617T patent/ATE238273T1/de active
- 1998-12-12 DE DE69813896T patent/DE69813896T2/de not_active Expired - Lifetime
- 1998-12-12 IL IL13673498A patent/IL136734A0/xx active IP Right Grant
- 1998-12-12 DK DK98966617T patent/DK1045830T3/da active
- 1998-12-12 NZ NZ505440A patent/NZ505440A/en not_active IP Right Cessation
- 1998-12-12 US US09/582,198 patent/US6306903B1/en not_active Ceased
- 1998-12-12 WO PCT/EP1998/008157 patent/WO1999035125A1/en active IP Right Grant
- 1998-12-12 EP EP98966617A patent/EP1045830B1/en not_active Expired - Lifetime
-
2000
- 2000-06-13 IL IL136734A patent/IL136734A/en not_active IP Right Cessation
- 2000-06-29 NO NO20003399A patent/NO327453B1/no not_active IP Right Cessation
- 2000-11-20 HK HK00107398A patent/HK1028020A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU228995B1 (en) | 2013-07-29 |
JP2002508302A (ja) | 2002-03-19 |
IL136734A0 (en) | 2001-06-14 |
JP4410930B2 (ja) | 2010-02-10 |
EP1045830A1 (en) | 2000-10-25 |
BR9814548A (pt) | 2000-10-10 |
KR100525587B1 (ko) | 2005-11-03 |
IL136734A (en) | 2007-03-08 |
KR20010033706A (ko) | 2001-04-25 |
NO20003399L (no) | 2000-08-02 |
EP1045830B1 (en) | 2003-04-23 |
DK1045830T3 (da) | 2003-08-04 |
NO20003399D0 (no) | 2000-06-29 |
GB9727523D0 (en) | 1998-02-25 |
PT1045830E (pt) | 2003-08-29 |
NZ505440A (en) | 2002-02-01 |
CA2316902A1 (en) | 1999-07-15 |
CA2316902C (en) | 2006-06-06 |
ATE238273T1 (de) | 2003-05-15 |
DE69813896D1 (de) | 2003-05-28 |
NO327453B1 (no) | 2009-07-06 |
EA002763B1 (ru) | 2002-08-29 |
HUP0100870A2 (hu) | 2001-07-30 |
ES2194392T3 (es) | 2003-11-16 |
HK1028020A1 (en) | 2001-02-02 |
WO1999035125A1 (en) | 1999-07-15 |
DE69813896T2 (de) | 2003-11-06 |
HUP0100870A3 (en) | 2002-11-28 |
US6306903B1 (en) | 2001-10-23 |
USRE40259E1 (en) | 2008-04-22 |
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