PT1045830E - Derivados alfa-aminoamidas uteis como agentes analgesicos - Google Patents

Derivados alfa-aminoamidas uteis como agentes analgesicos

Info

Publication number
PT1045830E
PT1045830E PT98966617T PT98966617T PT1045830E PT 1045830 E PT1045830 E PT 1045830E PT 98966617 T PT98966617 T PT 98966617T PT 98966617 T PT98966617 T PT 98966617T PT 1045830 E PT1045830 E PT 1045830E
Authority
PT
Portugal
Prior art keywords
sub
hydrogen
alkyl
integer
present
Prior art date
Application number
PT98966617T
Other languages
English (en)
Inventor
Patricia Salvati
Paolo Pevarello
Mario Varasi
Claes Post
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10824342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1045830(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of PT1045830E publication Critical patent/PT1045830E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
PT98966617T 1997-12-31 1998-12-12 Derivados alfa-aminoamidas uteis como agentes analgesicos PT1045830E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9727523.4A GB9727523D0 (en) 1997-12-31 1997-12-31 Alpha-aminoamide derivatives useful as analgesic agents

Publications (1)

Publication Number Publication Date
PT1045830E true PT1045830E (pt) 2003-08-29

Family

ID=10824342

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98966617T PT1045830E (pt) 1997-12-31 1998-12-12 Derivados alfa-aminoamidas uteis como agentes analgesicos

Country Status (19)

Country Link
US (2) USRE40259E1 (pt)
EP (1) EP1045830B1 (pt)
JP (1) JP4410930B2 (pt)
KR (1) KR100525587B1 (pt)
AT (1) ATE238273T1 (pt)
BR (1) BR9814548A (pt)
CA (1) CA2316902C (pt)
DE (1) DE69813896T2 (pt)
DK (1) DK1045830T3 (pt)
EA (1) EA002763B1 (pt)
ES (1) ES2194392T3 (pt)
GB (1) GB9727523D0 (pt)
HK (1) HK1028020A1 (pt)
HU (1) HU228995B1 (pt)
IL (2) IL136734A0 (pt)
NO (1) NO327453B1 (pt)
NZ (1) NZ505440A (pt)
PT (1) PT1045830E (pt)
WO (1) WO1999035125A1 (pt)

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IL160523A0 (en) * 2001-09-03 2004-07-25 Newron Pharm Spa PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
WO2004087125A1 (en) * 2003-04-02 2004-10-14 Ionix Pharmaceuticals Limited Amino acid derivatives as inhibitors of mammalian sodium channels
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
WO2005000309A2 (en) * 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
US20070276046A1 (en) * 2003-08-25 2007-11-29 Patricia Salvati Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
EP1533302A1 (en) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. Histidine derivatives
EP1533298A1 (en) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. 3-aminopyrrolidone derivatives
EP1535908A1 (en) * 2003-11-24 2005-06-01 Newron Pharmaceuticals S.p.A. N-acyl-N'-benzyl-alkylendiamino drivatives
EP1533295A1 (en) 2003-11-24 2005-05-25 Newron Pharmaceuticals S.p.A. Cyclopentyl Derivatives
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
NZ553970A (en) * 2004-09-10 2010-01-29 Newron Pharm Spa Use of (halobenzyloxy)benzylamino-propanamides for the manufacture of medicaments active as sodium and/or calcium channel selective modulators
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
JP5139307B2 (ja) * 2005-10-10 2013-02-06 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
US7855227B2 (en) 2005-12-22 2010-12-21 Newron Pharmaceuticals S.P.A. 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
EP2029524B1 (en) 2006-06-19 2014-11-26 Newron Pharmaceuticals S.p.A. Process for the production of 2- [4 - ( 3- and 2-fluorobenzyloxy) benzylamino] propan amides
MX2009013119A (es) * 2007-06-15 2010-03-04 Newron Pharm Spa Derivados de 2-[2-(fenil)etilamino]alcanamida sustituidos y su uso como moduladores del canal de sodio y/o potasio.
WO2009074478A1 (en) 2007-12-11 2009-06-18 Newron Pharmaceuticals S.P.A. Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree
EP2314569A1 (en) 2009-10-22 2011-04-27 Merck Patent GmbH Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
US9505708B2 (en) 2010-04-27 2016-11-29 Newron Pharmaceuticals S.P.A. Process for the production of ralfinamide salts substantially free from impurities having genotoxic effects
CA2881322A1 (en) 2012-09-10 2014-03-13 F. Hoffmann-La Roche Ag 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
KR101705718B1 (ko) * 2013-12-30 2017-02-14 이화여자대학교 산학협력단 신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
EP3237379B1 (en) 2014-12-23 2022-04-06 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
JP2020536870A (ja) 2017-10-05 2020-12-17 バイオジェン インコーポレイテッド アルファカルボキサミドピロリジン誘導体の調製方法

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AU749214C (en) 1997-11-21 2006-03-30 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
GB9727521D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
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IL160523A0 (en) 2001-09-03 2004-07-25 Newron Pharm Spa PHARMACEUTICAL COMPOSITION COMPRISING GABAPENTIN OR AN ANALOGUE THEREOF AND AN alpha-AMINOAMIDE AND ITS ANALGESIC USE
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders

Also Published As

Publication number Publication date
EP1045830B1 (en) 2003-04-23
HK1028020A1 (en) 2001-02-02
US6306903B1 (en) 2001-10-23
NO327453B1 (no) 2009-07-06
DK1045830T3 (da) 2003-08-04
EA002763B1 (ru) 2002-08-29
EA200000731A1 (ru) 2001-02-26
USRE40259E1 (en) 2008-04-22
NZ505440A (en) 2002-02-01
NO20003399D0 (no) 2000-06-29
HUP0100870A2 (hu) 2001-07-30
DE69813896T2 (de) 2003-11-06
WO1999035125A1 (en) 1999-07-15
IL136734A0 (en) 2001-06-14
CA2316902A1 (en) 1999-07-15
IL136734A (en) 2007-03-08
KR100525587B1 (ko) 2005-11-03
JP2002508302A (ja) 2002-03-19
DE69813896D1 (de) 2003-05-28
EP1045830A1 (en) 2000-10-25
HUP0100870A3 (en) 2002-11-28
ATE238273T1 (de) 2003-05-15
BR9814548A (pt) 2000-10-10
KR20010033706A (ko) 2001-04-25
HU228995B1 (en) 2013-07-29
GB9727523D0 (en) 1998-02-25
CA2316902C (en) 2006-06-06
NO20003399L (no) 2000-08-02
JP4410930B2 (ja) 2010-02-10
ES2194392T3 (es) 2003-11-16

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