LU91162I2 - Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables. - Google Patents

Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables.

Info

Publication number
LU91162I2
LU91162I2 LU91162C LU91162C LU91162I2 LU 91162 I2 LU91162 I2 LU 91162I2 LU 91162 C LU91162 C LU 91162C LU 91162 C LU91162 C LU 91162C LU 91162 I2 LU91162 I2 LU 91162I2
Authority
LU
Luxembourg
Prior art keywords
alkyl
amino
alkoxy
halogen
optionally substituted
Prior art date
Application number
LU91162C
Other languages
English (en)
Original Assignee
Roche Palo Alto Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23755479&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91162(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Palo Alto Llc filed Critical Roche Palo Alto Llc
Publication of LU91162I2 publication Critical patent/LU91162I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
LU91162C 1989-11-28 2005-04-18 Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables. LU91162I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44208289A 1989-11-28 1989-11-28

Publications (1)

Publication Number Publication Date
LU91162I2 true LU91162I2 (fr) 2005-06-20

Family

ID=23755479

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91162C LU91162I2 (fr) 1989-11-28 2005-04-18 Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables.

Country Status (23)

Country Link
US (1) US5202333A (fr)
EP (1) EP0430190B1 (fr)
JP (1) JPH0662607B2 (fr)
KR (1) KR970007917B1 (fr)
AT (1) ATE124698T1 (fr)
AU (1) AU642178B2 (fr)
BR (1) BR1100680A (fr)
CA (1) CA2030718C (fr)
DE (2) DE69020694T2 (fr)
DK (1) DK0430190T3 (fr)
ES (1) ES2075121T3 (fr)
FI (1) FI98367C (fr)
HK (1) HK36097A (fr)
HU (1) HU218654B (fr)
IE (1) IE68434B1 (fr)
IL (2) IL96486A (fr)
LU (1) LU91162I2 (fr)
NL (1) NL300194I2 (fr)
NO (2) NO175309C (fr)
NZ (1) NZ236225A (fr)
PL (3) PL166267B1 (fr)
PT (1) PT96001B (fr)
ZA (1) ZA909529B (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218654B (hu) * 1989-11-28 2000-10-28 Syntex (U.S.A.) Inc. Triciklusos vegyületek, ezeket hatóanyagként tartalmazó gyógyászati készítmények és eljárás előállításukra
US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
EP1082959A1 (fr) 1991-09-20 2001-03-14 Glaxo Group Limited Utilisation des NK1-antagonistes pour le traitement de la depression
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en) * 1992-07-08 2004-01-06 Nektar Therapeutics Compositions and methods for the pulmonary delivery of aerosolized medicaments
DE69332105T2 (de) * 1992-09-29 2003-03-06 Inhale Therapeutic Systems San Pulmonale abgabe von aktiven fragmenten des parathormons
MX9603936A (es) * 1994-03-07 1997-05-31 Inhale Therapeutic Syst Metodos y composiciones para el suministro pulmonar de insulina.
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
GB2288732B (en) * 1994-04-13 1998-04-29 Quadrant Holdings Cambridge Pharmaceutical compositions
AU696387B2 (en) * 1994-05-18 1998-09-10 Inhale Therapeutic Systems, Inc. Methods and compositions for the dry powder formulation of interferons
US5567818A (en) * 1994-07-08 1996-10-22 Syntex (U.S.A.) Inc. Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein
US5510486A (en) * 1994-07-26 1996-04-23 Syntex (U.S.A.) Inc. Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one
US5492914A (en) * 1994-07-28 1996-02-20 Syntex (U.S.A.) Inc. 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
US20030035778A1 (en) * 1997-07-14 2003-02-20 Robert Platz Methods and compositions for the dry powder formulation of interferon
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
ATE434437T1 (de) * 1999-02-18 2009-07-15 Novasearch Ag Verwendung von antagonisten der 5-ht3-rezeptoren zur behandlung von muskuloeskeletalen erkrankungen
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
AU6124601A (en) 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
WO2001087305A2 (fr) * 2000-05-18 2001-11-22 Glaxo Group Limited Methode de traitement de la dyspepsie fonctionnelle
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
JP2005525357A (ja) 2002-02-20 2005-08-25 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー α７ニコチン性アセチルコリン受容体活性を伴うアザ二環式化合物
US20030187017A1 (en) * 2002-11-14 2003-10-02 Mangel Allen Wayne Method for treating functional dyspepsia
CA2505990C (fr) * 2002-11-15 2009-05-19 Helsinn Healthcare S.A. Methode pour traiter les vomissements
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
MY143789A (en) * 2003-02-18 2011-07-15 Helsinn Healthcare Sa Use of palonosetron treating post- operative nausea and vomiting
US20060167072A1 (en) * 2004-01-30 2006-07-27 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
CN100336508C (zh) * 2005-02-23 2007-09-12 重庆医药工业研究院有限责任公司 一种稳定的帕洛诺司琼注射液
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
US20080004260A1 (en) * 2006-06-29 2008-01-03 Transcept Pharmaceuticals, Inc. Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions
US8614225B2 (en) * 2006-08-30 2013-12-24 Dr. Reddy's Laboratories Limited Process for the purification of palonosetron or its salt
EP1966197A2 (fr) * 2006-10-23 2008-09-10 Sicor, Inc. Processus de préparation de sels de palonosetron
KR101441459B1 (ko) * 2006-10-24 2014-09-18 헬신 헬쓰케어 에스.에이. 안정성 및 생체이용률이 개선된 염산 팔로노세트론을 포함하는 연질 캡슐
US20100105724A1 (en) * 2006-12-07 2010-04-29 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
US8334388B2 (en) * 2007-05-29 2012-12-18 Chemagis Ltd. Palonosetron salts and processes for preparation and purification thereof
US20090227623A1 (en) * 2007-09-15 2009-09-10 Protia, Llc Deuterium-enriched palosetron
CN101157691B (zh) * 2007-10-18 2011-01-12 杭州九源基因工程有限公司 一种盐酸帕洛诺司琼的生产工艺
AR069625A1 (es) * 2007-12-13 2010-02-03 Glenmark Generics Ltd Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (fr) * 2008-01-11 2009-07-16 Natco Pharma Limited Nouvelles formes cristallines du chlorhydrate de palonosétron
WO2009136405A1 (fr) * 2008-05-05 2009-11-12 Natco Pharma Limited Palonosétron de pureté élevée et ses caractéristiques à l’état solide
US20100048607A1 (en) * 2008-08-25 2010-02-25 Chandrashekhar Kocherlakota Formulations comprising palonosetron
US20100099701A1 (en) * 2008-10-20 2010-04-22 Auspex Pharmaceuticals, Inc. Isoquinolinone modulators of 5-ht3 receptors
WO2010056656A2 (fr) * 2008-11-11 2010-05-20 Dr. Reddy's Laboratories Ltd. Synthèse de chlorhydrate de palonosétron cristallin
US20100143461A1 (en) * 2008-12-08 2010-06-10 Ben-Zion Solomon Palonosetron formulation
WO2010068827A1 (fr) * 2008-12-11 2010-06-17 A.P. Pharma, Inc. Procédés pour augmenter la stabilité de polyorthoesters et leurs formulations
CN101851233B (zh) * 2009-04-03 2013-03-06 四川滇虹医药开发有限公司 盐酸帕洛诺司琼和其前体化合物及制备
CN101849904A (zh) * 2009-04-03 2010-10-06 南京长澳医药科技有限公司 一种帕洛诺司琼注射液及其制备方法
US20100298397A1 (en) * 2009-05-19 2010-11-25 Singh Nikhilesh N Method of treatment of obsessive compulsive disorder with ondansetron
HUE037300T2 (hu) 2009-05-20 2018-08-28 Inst Nat Sante Rech Med Szerotonin 5-HT3 receptor antagonisták lezionális vesztibuláris zavarok kezelésében való felhasználásra
EP2253316B1 (fr) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur 5-HT3 de la sérotonine pour une utilisation dans le traitement ou la prévention d'une pathologie de l'oreille interne avec déficits vestibulaires
WO2011001400A2 (fr) 2009-06-30 2011-01-06 Ranbaxy Laboratories Limited Procédés de préparation des formes i et ii de l'hydrochlorure de palonosétron
SG177523A1 (en) 2009-07-14 2012-02-28 Albany Molecular Res Inc 5-ht3 receptor modulators, methods of making, and use thereof
WO2011013095A1 (fr) 2009-07-31 2011-02-03 Ranbaxy Laboratories Limited Procédés de préparation du palonosétron
CN102781939A (zh) * 2009-11-13 2012-11-14 赫尔辛医疗股份公司 帕洛诺司琼代谢物
CN104856998A (zh) 2009-11-18 2015-08-26 赫尔辛医疗股份公司 用于治疗中枢介导的恶心及呕吐的组合物及方法
EP2722045B1 (fr) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions pour traiter les nausées et vomissements à médiation centrale
JP2014530249A (ja) 2011-10-18 2014-11-17 ヘルシン ヘルスケア ソシエテ アノニム ネツピタントおよびパロノセトロンの治療学的組合せ
CN102688185B (zh) * 2012-06-01 2013-07-10 齐鲁制药(海南)有限公司 一种稳定的帕洛诺司琼注射液及其制备方法
EP3087987A4 (fr) * 2013-12-23 2017-08-02 Samyang Biopharmaceuticals Corporation Composition pharmaceutique contenant du palonosétron
CA2996717A1 (fr) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Combinaison muscarinique et son utilisation pour lutter contre des troubles hypocholinergiques du systeme nerveux central
EP3672964A4 (fr) 2017-08-21 2021-05-26 Leiutis Pharmaceuticals Pvt. Ltd. Nouvelles formulations à triple combinaison pour une thérapie antiémétique

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341528A (en) * 1963-11-07 1967-09-12 Warner Lambert Pharmaceutical Substituted benzoquinolines
US3896132A (en) * 1969-08-19 1975-07-22 Hoffmann La Roche Process for preparing 1,2,3,8,9,9a-hexahydro-5,6-dialkoxy-1-alkyl-benzo(d,e)quinolin-7-ore compounds
US4309543A (en) * 1980-03-17 1982-01-05 Dynapol Process for preparing cyclic amides
EP0093488A3 (fr) * 1982-03-18 1984-05-23 Beecham Group Plc Composés nortropyl benzopyrrolinoniques, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
WO1988004292A1 (fr) * 1986-12-11 1988-06-16 The Upjohn Company Amino-polyhydro-benzo-(iso)quinoleines a proprietes antipsychotiques et produits intermediaires
DE3850742T2 (de) * 1987-11-04 1994-10-27 Beecham Group Plc Neue 4-Oxobenzotriazine und 4-Oxochinazoline.
HU218654B (hu) * 1989-11-28 2000-10-28 Syntex (U.S.A.) Inc. Triciklusos vegyületek, ezeket hatóanyagként tartalmazó gyógyászati készítmények és eljárás előállításukra
AU7618991A (en) * 1990-05-14 1991-11-14 Syntex (U.S.A.) Inc. Novel tricyclic compounds
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists

Also Published As

Publication number Publication date
NO2005023I1 (no) 2005-10-03
NO905120D0 (no) 1990-11-27
CA2030718A1 (fr) 1991-05-29
NO175309C (no) 1994-09-28
AU642178B2 (en) 1993-10-14
NL300194I1 (nl) 2005-07-01
PL166277B1 (pl) 1995-04-28
HU907660D0 (en) 1991-06-28
DE122005000027I1 (de) 2005-08-04
PT96001B (pt) 1998-01-30
NL300194I2 (nl) 2005-07-01
FI905839A (fi) 1991-05-29
US5202333A (en) 1993-04-13
BR1100680A (pt) 2000-02-08
AU6696390A (en) 1991-06-06
IE904269A1 (en) 1991-06-05
IL96486A0 (en) 1991-08-16
DE69020694D1 (de) 1995-08-10
JPH03176486A (ja) 1991-07-31
FI98367B (fi) 1997-02-28
HK36097A (en) 1997-03-27
FI905839A0 (fi) 1990-11-27
IE68434B1 (en) 1996-06-12
DE122005000027I2 (de) 2006-03-16
NO175309B (no) 1994-06-20
CA2030718C (fr) 1998-05-12
NZ236225A (en) 1992-09-25
IL96486A (en) 1995-03-30
KR910009699A (ko) 1991-06-28
EP0430190B1 (fr) 1995-07-05
DK0430190T3 (da) 1995-08-21
PL166272B1 (pl) 1995-04-28
ATE124698T1 (de) 1995-07-15
ZA909529B (en) 1992-08-26
EP0430190A3 (en) 1992-01-22
JPH0662607B2 (ja) 1994-08-17
NO2005023I2 (no) 2009-10-05
EP0430190A2 (fr) 1991-06-05
FI98367C (fi) 1997-06-10
KR970007917B1 (ko) 1997-05-17
ES2075121T3 (es) 1995-10-01
PL166267B1 (pl) 1995-04-28
PL287961A1 (en) 1991-12-02
PT96001A (pt) 1991-09-30
NO905120L (no) 1991-05-29
HU218654B (hu) 2000-10-28
DE69020694T2 (de) 1996-01-18
HUT56368A (en) 1991-08-28
IL110622A (en) 1995-03-30

Similar Documents

Publication Publication Date Title
LU91162I2 (fr) Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables.
KR900012911A (ko) 흥분성 아미노산 수용기 길항질 화합물
EA200000731A1 (ru) Альфа-аминоамидные производные, полезные в качестве анальгетических агентов
ATE219766T1 (de) N-acylierte 4-aminopiperidin derivate als aktive bestandteile von peripher gefässerweiternden wikstoffen
ATE297203T1 (de) Antithrombotische mitteln
EA200200873A1 (ru) Новые пиперазиновые производные
ATE306261T1 (de) Antithrombosemittel
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
ES2124545T3 (es) Azolidindionas como agentes antihiperglucemicos.
EA199800794A1 (ru) Новые производные арилглициламида, способ их получения и фармацевтическая композиция, содержащая эти соединения
TR199801782T2 (xx) Kinoksalindionlar
ID25477A (id) Turunan-turunan spiropiperidin
TW334428B (en) Novel benzodiazepine derivatives
DE69402703T2 (de) 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
EA200101050A1 (ru) Замещенные бензолактамные соединения
WO1997029077A1 (fr) Derives amides substitues
ATE264320T1 (de) 5-aminoalkyl- und 5-aminocarbonylsubstituierte indole