FI905839A0 - Menetelmä uusien terapeuttisesti käyttökelpoisten trisyklisten, typpipitoisten yhdisteiden valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten trisyklisten, typpipitoisten yhdisteiden valmistamiseksiInfo
- Publication number
- FI905839A0 FI905839A0 FI905839A FI905839A FI905839A0 FI 905839 A0 FI905839 A0 FI 905839A0 FI 905839 A FI905839 A FI 905839A FI 905839 A FI905839 A FI 905839A FI 905839 A0 FI905839 A0 FI 905839A0
- Authority
- FI
- Finland
- Prior art keywords
- alkyl
- amino
- alkoxy
- halogen
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44208289A | 1989-11-28 | 1989-11-28 | |
US44208289 | 1989-11-28 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI905839A0 true FI905839A0 (fi) | 1990-11-27 |
FI905839A FI905839A (fi) | 1991-05-29 |
FI98367B FI98367B (fi) | 1997-02-28 |
FI98367C FI98367C (fi) | 1997-06-10 |
Family
ID=23755479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI905839A FI98367C (fi) | 1989-11-28 | 1990-11-27 | Menetelmä uusien terapeuttisesti käyttökelpoisten trisyklisten, typpipitoisten yhdisteiden valmistamiseksi |
Country Status (23)
Country | Link |
---|---|
US (1) | US5202333A (fi) |
EP (1) | EP0430190B1 (fi) |
JP (1) | JPH0662607B2 (fi) |
KR (1) | KR970007917B1 (fi) |
AT (1) | ATE124698T1 (fi) |
AU (1) | AU642178B2 (fi) |
BR (1) | BR1100680A (fi) |
CA (1) | CA2030718C (fi) |
DE (2) | DE122005000027I2 (fi) |
DK (1) | DK0430190T3 (fi) |
ES (1) | ES2075121T3 (fi) |
FI (1) | FI98367C (fi) |
HK (1) | HK36097A (fi) |
HU (1) | HU218654B (fi) |
IE (1) | IE68434B1 (fi) |
IL (2) | IL110622A (fi) |
LU (1) | LU91162I2 (fi) |
NL (1) | NL300194I2 (fi) |
NO (2) | NO175309C (fi) |
NZ (1) | NZ236225A (fi) |
PL (3) | PL166277B1 (fi) |
PT (1) | PT96001B (fi) |
ZA (1) | ZA909529B (fi) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE68434B1 (en) * | 1989-11-28 | 1996-06-12 | Syntex Inc | New tricyclic compounds |
US5491148A (en) * | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
PT533280E (pt) * | 1991-09-20 | 2001-01-31 | Glaxo Group Ltd | Novas utilizacoes medicas para antagonistas de taquiquinina |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
WO1994007514A1 (en) * | 1992-09-29 | 1994-04-14 | Inhale Therapeutic Systems | Pulmonary delivery of active fragments of parathyroid hormone |
US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
EP1462096B1 (en) * | 1994-03-07 | 2008-12-10 | Nektar Therapeutics | Methods and compositions for pulmonary delivery of insulin |
GB2288732B (en) * | 1994-04-13 | 1998-04-29 | Quadrant Holdings Cambridge | Pharmaceutical compositions |
KR100384353B1 (ko) * | 1994-05-18 | 2003-10-04 | 네크타르 테라퓨틱스 | 인터페론의건조분말제형을제조하기위한방법및조성물 |
US5567818A (en) * | 1994-07-08 | 1996-10-22 | Syntex (U.S.A.) Inc. | Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein |
US5510486A (en) * | 1994-07-26 | 1996-04-23 | Syntex (U.S.A.) Inc. | Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one |
US5492914A (en) * | 1994-07-28 | 1996-02-20 | Syntex (U.S.A.) Inc. | 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US5723103A (en) * | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
JP2002537245A (ja) * | 1999-02-18 | 2002-11-05 | ノバルティス アクチエンゲゼルシャフト | 5−ht3レセプターアンタゴニストの使用 |
US7871598B1 (en) * | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
CA2382133C (en) | 2000-05-10 | 2010-11-23 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
US20050042194A1 (en) * | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
AU2001261606A1 (en) * | 2000-05-18 | 2001-11-26 | Glaxo Group Limited | Method for treating functional dyspepsia |
SI1458360T1 (sl) | 2001-12-19 | 2011-08-31 | Novartis Ag | Pulmonalno dajanje aminoglikozidov |
EP1478646A1 (en) | 2002-02-20 | 2004-11-24 | PHARMACIA & UPJOHN COMPANY | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
US20030187017A1 (en) * | 2002-11-14 | 2003-10-02 | Mangel Allen Wayne | Method for treating functional dyspepsia |
WO2004045615A1 (en) * | 2002-11-15 | 2004-06-03 | Helsinn Healthcare Sa | Palonosetron for the treatment of chemotherapy-induced emesis |
US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
TWI355936B (en) * | 2003-02-18 | 2012-01-11 | Helsinn Healthcare Sa | Uses of palonosetron hydrochloride |
US20060167072A1 (en) * | 2004-01-30 | 2006-07-27 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
CN100336508C (zh) * | 2005-02-23 | 2007-09-12 | 重庆医药工业研究院有限责任公司 | 一种稳定的帕洛诺司琼注射液 |
US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
US20080004260A1 (en) * | 2006-06-29 | 2008-01-03 | Transcept Pharmaceuticals, Inc. | Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions |
US8614225B2 (en) * | 2006-08-30 | 2013-12-24 | Dr. Reddy's Laboratories Limited | Process for the purification of palonosetron or its salt |
WO2008051539A2 (en) * | 2006-10-23 | 2008-05-02 | Sicor Inc. | Processes for preparing palonosetron salts |
NZ576237A (en) * | 2006-10-24 | 2011-12-22 | Helsinn Healthcare Sa | Soft capsules comprising palonosetron hydrochloride having improved stability and bioavailability |
WO2008073757A1 (en) * | 2006-12-07 | 2008-06-19 | Helsinn Healthcare Sa | Crystalline and amorphous forms of palonosetron hydrochloride |
US8334388B2 (en) * | 2007-05-29 | 2012-12-18 | Chemagis Ltd. | Palonosetron salts and processes for preparation and purification thereof |
US20090227623A1 (en) * | 2007-09-15 | 2009-09-10 | Protia, Llc | Deuterium-enriched palosetron |
CN101157691B (zh) * | 2007-10-18 | 2011-01-12 | 杭州九源基因工程有限公司 | 一种盐酸帕洛诺司琼的生产工艺 |
AR069625A1 (es) * | 2007-12-13 | 2010-02-03 | Glenmark Generics Ltd | Base libre de palonosetron y procedimiento para su preparacion |
WO2009087643A1 (en) * | 2008-01-11 | 2009-07-16 | Natco Pharma Limited | Novel crystalline forms of palonosetron hydrochloride |
WO2009136405A1 (en) * | 2008-05-05 | 2009-11-12 | Natco Pharma Limited | High purity palonosetron base and its solid state characteristics |
US20100048607A1 (en) * | 2008-08-25 | 2010-02-25 | Chandrashekhar Kocherlakota | Formulations comprising palonosetron |
US20100099701A1 (en) * | 2008-10-20 | 2010-04-22 | Auspex Pharmaceuticals, Inc. | Isoquinolinone modulators of 5-ht3 receptors |
EP2364312A4 (en) * | 2008-11-11 | 2012-05-02 | Reddys Lab Ltd Dr | SYNTHESIS OF CRYSTALLINE PALONOSETRON CHLORHYDRATE |
WO2010077669A2 (en) | 2008-12-08 | 2010-07-08 | Teva Pharmaceutical Industries Ltd. | Palonosetron formulation |
CN102292076A (zh) * | 2008-12-11 | 2011-12-21 | 阿帕医药有限公司 | 增强聚原酸酯及其制剂的稳定性的方法 |
CN101849904A (zh) * | 2009-04-03 | 2010-10-06 | 南京长澳医药科技有限公司 | 一种帕洛诺司琼注射液及其制备方法 |
CN101851233B (zh) * | 2009-04-03 | 2013-03-06 | 四川滇虹医药开发有限公司 | 盐酸帕洛诺司琼和其前体化合物及制备 |
US20100298397A1 (en) * | 2009-05-19 | 2010-11-25 | Singh Nikhilesh N | Method of treatment of obsessive compulsive disorder with ondansetron |
PL2432467T3 (pl) | 2009-05-20 | 2018-07-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Zastosowanie antagonistów receptora 5-ht3 serotoniny w leczeniu zaburzeń przedsionkowych ze zmianami chorobowymi |
ES2432618T3 (es) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular |
WO2011001400A2 (en) | 2009-06-30 | 2011-01-06 | Ranbaxy Laboratories Limited | Processes for the preparation of form i and form ii of palonosetron hydrochloride |
CA2767233A1 (en) | 2009-07-14 | 2011-01-20 | Albany Molecular Research, Inc. | 5-ht3 receptor modulators, methods of making, and use thereof |
WO2011013095A1 (en) | 2009-07-31 | 2011-02-03 | Ranbaxy Laboratories Limited | Processes for the preparation of palonosetron |
EP2499137A1 (en) * | 2009-11-13 | 2012-09-19 | Helsinn Healthcare S.A. | Palonosetron metabolites |
ES2494015T3 (es) | 2009-11-18 | 2014-09-12 | Helsinn Healthcare Sa | Composiciones para tratar nauseas y vómitos de origen central |
EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
PL2744497T3 (pl) | 2011-10-18 | 2016-10-31 | Terapeutyczne połączenia netupitantu i palonosetronu | |
CN102688185B (zh) * | 2012-06-01 | 2013-07-10 | 齐鲁制药(海南)有限公司 | 一种稳定的帕洛诺司琼注射液及其制备方法 |
WO2015099381A1 (ko) | 2013-12-23 | 2015-07-02 | 주식회사 삼양바이오팜 | 팔로노세트론을 함유하는 약학 조성물 |
EP4019018A1 (en) | 2015-09-11 | 2022-06-29 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
EP3672964A4 (en) | 2017-08-21 | 2021-05-26 | Leiutis Pharmaceuticals Pvt. Ltd. | NEW TRIPLE COMBINATION FORMULATIONS FOR ANTIEMETIC THERAPY |
EP4385497A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Antioxidant-free fixed dose combination of netupitant and palonosetron |
EP4385500A1 (en) | 2022-12-12 | 2024-06-19 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Fixed dose combination comprising netupitant and palonosetron |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3341528A (en) * | 1963-11-07 | 1967-09-12 | Warner Lambert Pharmaceutical | Substituted benzoquinolines |
US3896132A (en) * | 1969-08-19 | 1975-07-22 | Hoffmann La Roche | Process for preparing 1,2,3,8,9,9a-hexahydro-5,6-dialkoxy-1-alkyl-benzo(d,e)quinolin-7-ore compounds |
US4309543A (en) * | 1980-03-17 | 1982-01-05 | Dynapol | Process for preparing cyclic amides |
EP0093488A3 (en) * | 1982-03-18 | 1984-05-23 | Beecham Group Plc | Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them |
US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
AU8325987A (en) * | 1986-12-11 | 1988-06-30 | Upjohn Company, The | Antipsychotic amino-polyhydro-benz-(iso)quinolines and intermediates |
DE3850742T2 (de) * | 1987-11-04 | 1994-10-27 | Beecham Group Plc | Neue 4-Oxobenzotriazine und 4-Oxochinazoline. |
IE68434B1 (en) * | 1989-11-28 | 1996-06-12 | Syntex Inc | New tricyclic compounds |
AU7618991A (en) * | 1990-05-14 | 1991-11-14 | Syntex (U.S.A.) Inc. | Novel tricyclic compounds |
US5189041A (en) * | 1990-11-16 | 1993-02-23 | Syntex (U.S.A.) Inc. | Tricyclic 5-ht3 receptor antagonists |
-
1990
- 1990-11-27 IE IE426990A patent/IE68434B1/en not_active IP Right Cessation
- 1990-11-27 PT PT96001A patent/PT96001B/pt not_active IP Right Cessation
- 1990-11-27 DK DK90122689.4T patent/DK0430190T3/da active
- 1990-11-27 IL IL11062290A patent/IL110622A/en not_active IP Right Cessation
- 1990-11-27 KR KR1019900019275A patent/KR970007917B1/ko not_active IP Right Cessation
- 1990-11-27 DE DE200512000027 patent/DE122005000027I2/de active Active
- 1990-11-27 FI FI905839A patent/FI98367C/fi active Protection Beyond IP Right Term
- 1990-11-27 JP JP2328764A patent/JPH0662607B2/ja not_active Expired - Fee Related
- 1990-11-27 AU AU66963/90A patent/AU642178B2/en not_active Expired
- 1990-11-27 DE DE69020694T patent/DE69020694T2/de not_active Expired - Lifetime
- 1990-11-27 ES ES90122689T patent/ES2075121T3/es not_active Expired - Lifetime
- 1990-11-27 EP EP90122689A patent/EP0430190B1/en not_active Expired - Lifetime
- 1990-11-27 CA CA002030718A patent/CA2030718C/en not_active Expired - Lifetime
- 1990-11-27 PL PL90303661A patent/PL166277B1/pl unknown
- 1990-11-27 IL IL9648690A patent/IL96486A/en active Protection Beyond IP Right Term
- 1990-11-27 HU HU670/90A patent/HU218654B/hu active Protection Beyond IP Right Term
- 1990-11-27 AT AT90122689T patent/ATE124698T1/de active
- 1990-11-27 NZ NZ236225A patent/NZ236225A/en unknown
- 1990-11-27 PL PL90303660A patent/PL166267B1/pl unknown
- 1990-11-27 ZA ZA909529A patent/ZA909529B/xx unknown
- 1990-11-27 PL PL90287961A patent/PL166272B1/pl unknown
- 1990-11-27 NO NO905120A patent/NO175309C/no not_active IP Right Cessation
-
1991
- 1991-05-22 US US07/704,565 patent/US5202333A/en not_active Expired - Lifetime
-
1997
- 1997-03-20 HK HK36097A patent/HK36097A/xx not_active IP Right Cessation
- 1997-05-08 BR BR1100680-3A patent/BR1100680A/pt active IP Right Grant
-
2005
- 2005-04-18 LU LU91162C patent/LU91162I2/fr unknown
- 2005-04-20 NL NL300194C patent/NL300194I2/nl unknown
- 2005-09-21 NO NO2005023C patent/NO2005023I2/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI98367B (fi) | Menetelmä uusien terapeuttisesti käyttökelpoisten trisyklisten, typpipitoisten yhdisteiden valmistamiseksi | |
EA200100553A1 (ru) | Замещенные бициклические производные, полезные в качестве противораковых агентов | |
KR900012911A (ko) | 흥분성 아미노산 수용기 길항질 화합물 | |
EA199800794A1 (ru) | Новые производные арилглициламида, способ их получения и фармацевтическая композиция, содержащая эти соединения | |
EA200000792A2 (ru) | Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции | |
DK0453042T3 (da) | Hidtil ukendte 2 9-disubstituerede 4H-pyhrido[1 2-a]pyridin-4-oner | |
ATE116974T1 (de) | 5- piperazinylalkyl-1,5-benzothiazepinone verwendbar als calciumantagonisten. | |
FI891807A (fi) | Menetelmä terapeuttisesti aktiivisten oktahydropyrrolo-pyratsino/2,1-i/indol-2-oni-johdannaisten valmistamiseksi | |
PT89492A (pt) | Processo de preparacao de novos derivados de tioformamida terapeuticamente activos | |
DE69402703D1 (de) | 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND | |
WO1997029077A1 (fr) | Derives amides substitues |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
FG | Patent granted |
Owner name: SYNTEX (U.S.A.) INC. |
|
SPCF | Supplementary protection certificate application filed |
Spc suppl protection certif: L20050012 |
|
PC | Transfer of assignment of patent |
Owner name: ROCHE PALO ALTO LLC Free format text: ROCHE PALO ALTO LLC |
|
SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: NUMBER:225 |