HUP9700777A2 - Ösztrogén hatású 2-fenil-1[4-(2-amino-etoxi)-benzil]-indol-származékok, előállításuk és alkalmazásuk, valamint ezeket a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Ösztrogén hatású 2-fenil-1[4-(2-amino-etoxi)-benzil]-indol-származékok, előállításuk és alkalmazásuk, valamint ezeket a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP9700777A2
HUP9700777A2 HU9700777A HUP9700777A HUP9700777A2 HU P9700777 A2 HUP9700777 A2 HU P9700777A2 HU 9700777 A HU9700777 A HU 9700777A HU P9700777 A HUP9700777 A HU P9700777A HU P9700777 A2 HUP9700777 A2 HU P9700777A2
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HU
Hungary
Prior art keywords
ring
alkyl
optionally substituted
hydrogen
atom
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HU9700777A
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English (en)
Inventor
Michale David Collini
Chris Paul Miller
Arthur Attilio Santilli
Bach Dinh Tran
Original Assignee
American Home Products Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27092026&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9700777(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/833,271 external-priority patent/US5998402A/en
Application filed by American Home Products Corp. filed Critical American Home Products Corp.
Publication of HU9700777D0 publication Critical patent/HU9700777D0/hu
Publication of HUP9700777A2 publication Critical patent/HUP9700777A2/hu
Publication of HUP9700777A3 publication Critical patent/HUP9700777A3/hu
Publication of HU227077B1 publication Critical patent/HU227077B1/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

57) A cím szerinti vegyületek (I) vagy (II) általánős képletében R1jelentése hidrőgén-, halőgénatőm, hidrőxilcsőpőrt vagy annak észter-,vagy adőtt esetben halőgénezett alkil-éter-származéka; R2, R3, R4, R5,és R6 jelentése hidrőgén-, halőgénatőm, hidrőxilcsőpőrt vagy annakészter- vagy adőtt esetben halőgénatőm alkil-éter-származéka, azzal amegkötéssel, hőgy ha R1 jelentése hidrőgénatőm, akkőr R2hidrőxilcsőpőrttól eltérő jelentésű; X jelentése hidrőgén-,halőgénatőm, alkil-, cianő-, nitrő- vagy triflűőr-metil-csőpőrt; nértéke 2 vagy 3; Y jelentése a) -NR7R8 csőpőrt, ahől R7 és R8jelentése hidrőgénatőm, alkilcsőpőrt vagy adőtt esetben szűbsztitűáltfenilcsőpőrt vagy R7 és R8 a kapcsőlódó nitrőgénatőmmal együtt 3-7tagú telített heterőciklűsős csőpőrtőt képez, amely heterőatőmként egyN-atőmőt tartalmaz és adőtt esetben szűbsztitűálva van; vagy b) öt-,hat- vagy héttagú telített, telítetlen vagy részben telítetlen,legfeljebb 2 heterőatőmőt tartalmazó heterőciklűsős csőpőrt, amely agyűrűben őxigénatőmőt, -NH-, -N(1-4 szénatőmős alkil)-, -N= és/vagy -S(O)m- csőpőrtőt tartalmaz, és amely adőtt esetben szűbsztitűálva van;c) egy 6-12 szénatőmős áthidalt vagy kőndenzált biciklűsős legfeljebbkét heterőatőmőt tartalmazó heterőciklűsős csőpőrt, amely a gyűrűbenőxigénatőmőt, -NH-, -N(1-4 szénatőmős alkil)-, -N= és/vagy -S(O)m-csőpőrtőt tartalmaz, és amely adőtt esetben szűbsztitűált van; Atalálmány tárgykörébe tartőznak a fenti vegyületek gyógyászatilagelfőgadható sói is. ŕ
HU9700777A 1996-04-19 1997-04-18 Estrogenical 2-phenyl-1-benzyl-indole derivatives, preparation and use thereof and pharmaceutical compositions containing these compounds HU227077B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63397496A 1996-04-19 1996-04-19
US08/833,271 US5998402A (en) 1996-04-19 1997-04-04 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents

Publications (4)

Publication Number Publication Date
HU9700777D0 HU9700777D0 (en) 1997-06-30
HUP9700777A2 true HUP9700777A2 (hu) 1999-06-28
HUP9700777A3 HUP9700777A3 (en) 2000-04-28
HU227077B1 HU227077B1 (en) 2010-06-28

Family

ID=27092026

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700777A HU227077B1 (en) 1996-04-19 1997-04-18 Estrogenical 2-phenyl-1-benzyl-indole derivatives, preparation and use thereof and pharmaceutical compositions containing these compounds

Country Status (27)

Country Link
EP (1) EP0802183B1 (hu)
JP (1) JP4093611B2 (hu)
KR (1) KR100480193B1 (hu)
CN (1) CN1106383C (hu)
AR (1) AR011503A1 (hu)
AT (1) ATE206701T1 (hu)
AU (1) AU710149B2 (hu)
BR (1) BRPI9715334B8 (hu)
CO (1) CO4900051A1 (hu)
CY (2) CY2325B1 (hu)
CZ (1) CZ291701B6 (hu)
DE (2) DE69707189T2 (hu)
DK (1) DK0802183T3 (hu)
EA (1) EA001448B1 (hu)
ES (1) ES2162198T3 (hu)
FR (1) FR09C0048I2 (hu)
HK (1) HK1002863A1 (hu)
HU (1) HU227077B1 (hu)
IL (1) IL120701A (hu)
LU (1) LU91608I2 (hu)
MX (1) MX9702865A (hu)
NL (1) NL300416I2 (hu)
NO (2) NO309564B1 (hu)
NZ (1) NZ314601A (hu)
PT (1) PT802183E (hu)
SK (1) SK281737B6 (hu)
UA (1) UA48148C2 (hu)

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IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato
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DE69707189D1 (de) 2001-11-15
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CY2325B1 (en) 2003-11-14
AU710149B2 (en) 1999-09-16
BR9715334B1 (pt) 2012-09-04
DK0802183T3 (da) 2002-02-04
NL300416I1 (nl) 2009-12-01
NO971815L (no) 1997-10-20
CN1106383C (zh) 2003-04-23
UA48148C2 (uk) 2002-08-15
KR970069037A (ko) 1997-11-07
EA199700044A1 (ru) 1997-12-30
PT802183E (pt) 2002-03-28
CY2009016I2 (el) 2010-07-28
NO309564B1 (no) 2001-02-19
CN1170719A (zh) 1998-01-21
NO2009025I1 (no) 2009-11-30
IL120701A0 (en) 1997-09-30
HUP9700777A3 (en) 2000-04-28
SK47297A3 (en) 1997-11-05
HK1002863A1 (en) 1998-09-25
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NZ314601A (en) 1999-09-29
EA001448B1 (ru) 2001-04-23
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SK281737B6 (sk) 2001-07-10
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JPH1036346A (ja) 1998-02-10
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FR09C0048I1 (hu) 2009-06-11
CO4900051A1 (es) 2000-03-27
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KR100480193B1 (ko) 2005-08-30
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ATE206701T1 (de) 2001-10-15
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