ITMI951900A0 - Derivati idroisochinolinici sostituiti - Google Patents

Derivati idroisochinolinici sostituiti

Info

Publication number
ITMI951900A0
ITMI951900A0 ITMI951900A ITMI951900A ITMI951900A0 IT MI951900 A0 ITMI951900 A0 IT MI951900A0 IT MI951900 A ITMI951900 A IT MI951900A IT MI951900 A ITMI951900 A IT MI951900A IT MI951900 A0 ITMI951900 A0 IT MI951900A0
Authority
IT
Italy
Prior art keywords
substituted
hydroisoquinoline
derivatives
hydroisoquinoline derivatives
substituted hydroisoquinoline
Prior art date
Application number
ITMI951900A
Other languages
English (en)
Inventor
Giulio Dondio
Silvano Ronzoni
Original Assignee
Giulio Dondio
Silvano Ronzoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giulio Dondio, Silvano Ronzoni filed Critical Giulio Dondio
Priority to IT1995MI001900A priority Critical patent/IT1307327B1/it
Publication of ITMI951900A0 publication Critical patent/ITMI951900A0/it
Priority to PCT/EP1996/004036 priority patent/WO1997010216A1/en
Priority to EP96932527A priority patent/EP0854868A1/en
Priority to JP9511672A priority patent/JPH11512415A/ja
Priority to US09/029,621 priority patent/US5968949A/en
Publication of ITMI951900A1 publication Critical patent/ITMI951900A1/it
Application granted granted Critical
Publication of IT1307327B1 publication Critical patent/IT1307327B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
IT1995MI001900A 1995-09-12 1995-09-12 Derivati idroisochinolinici sostituiti IT1307327B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT1995MI001900A IT1307327B1 (it) 1995-09-12 1995-09-12 Derivati idroisochinolinici sostituiti
PCT/EP1996/004036 WO1997010216A1 (en) 1995-09-12 1996-09-12 Substituted hydroisoquinoline derivatives and their use as pharmaceuticals
EP96932527A EP0854868A1 (en) 1995-09-12 1996-09-12 Substituted hydroisoquinoline derivatives and their use as pharmaceuticals
JP9511672A JPH11512415A (ja) 1995-09-12 1996-09-12 置換されたヒドロイソキノリン誘導体および医薬としてのその使用
US09/029,621 US5968949A (en) 1995-09-12 1996-09-12 Substituted hydroisoquinoline derivatives and their use as pharmaceuticals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1995MI001900A IT1307327B1 (it) 1995-09-12 1995-09-12 Derivati idroisochinolinici sostituiti

Publications (3)

Publication Number Publication Date
ITMI951900A0 true ITMI951900A0 (it) 1995-09-12
ITMI951900A1 ITMI951900A1 (it) 1997-03-12
IT1307327B1 IT1307327B1 (it) 2001-10-30

Family

ID=11372234

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1995MI001900A IT1307327B1 (it) 1995-09-12 1995-09-12 Derivati idroisochinolinici sostituiti

Country Status (5)

Country Link
US (1) US5968949A (it)
EP (1) EP0854868A1 (it)
JP (1) JPH11512415A (it)
IT (1) IT1307327B1 (it)
WO (1) WO1997010216A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002157A1 (fr) * 1997-07-09 1999-01-21 Toray Industries, Inc. Antitussifs
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
WO1999045925A1 (en) * 1998-03-10 1999-09-16 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
KR100898562B1 (ko) 2001-10-15 2009-05-20 얀센 파마슈티카 엔.브이. 신규 치환된 4-페닐-4-[1ｈ-이미다졸-2-일]-피페리딘유도체 및 선택적인 비펩타이드 델타 아편유사작용제로서의 그의 용도
BRPI0415165A (pt) 2003-10-01 2007-01-09 Adolor Corp composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2063886A2 (en) 2006-09-12 2009-06-03 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) * 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
KR20160020584A (ko) 2007-01-22 2016-02-23 지티엑스, 인코포레이티드 핵 수용체에 결합하는 물질

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2336559A1 (de) * 1972-07-20 1974-01-31 Du Pont 4a-aryl-trans-decahydrochinoline und verfahren zu ihrer herstellung
SE7509022L (sv) * 1974-09-09 1976-03-10 Du Pont Foreningar med analgetisk verkan
US4077954A (en) * 1976-02-10 1978-03-07 E. I. Du Pont De Nemours And Company N-(p-methylphenethyl)-4a-aryl-trans-decahydroisoquinolines

Also Published As

Publication number Publication date
EP0854868A1 (en) 1998-07-29
WO1997010216A1 (en) 1997-03-20
US5968949A (en) 1999-10-19
JPH11512415A (ja) 1999-10-26
ITMI951900A1 (it) 1997-03-12
IT1307327B1 (it) 2001-10-30

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