ES2032750T3 - Profarmacos de rapamicina. - Google Patents

Profarmacos de rapamicina.

Info

Publication number
ES2032750T3
ES2032750T3 ES198686309449T ES86309449T ES2032750T3 ES 2032750 T3 ES2032750 T3 ES 2032750T3 ES 198686309449 T ES198686309449 T ES 198686309449T ES 86309449 T ES86309449 T ES 86309449T ES 2032750 T3 ES2032750 T3 ES 2032750T3
Authority
ES
Spain
Prior art keywords
sub
carbon atoms
rapamicine
drugs
prodrugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686309449T
Other languages
English (en)
Inventor
Valentino John Stella
Paul Edwin Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kansas
Original Assignee
University of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kansas filed Critical University of Kansas
Application granted granted Critical
Publication of ES2032750T3 publication Critical patent/ES2032750T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PRODROGAS DE RAPAMICINA SOLUBLES EN AGUA SE HA DESCUBIERTO QUE SON UTILES COMO COMPONENTES EN FORMULAS FARMACEUTICAS INYECTABLES PARA EL TRATAMIENTO DE TUMORES DE MAMIFEROS. DICHAS PRODROGAS SON DERIVADOS DE RAPAMICINA O DE SUS SALES MONOSUSTITUIDAS EN POSICION 28 O DISUSTITUIDAS EN POSICION 28 O/Y 43 POR UN SUSTITUYENTE ACILAMINO DE FORMULA FIG01 DONDE N ES UN NUMERO ENTERO ENTRE 1 Y 3 Y R1 Y R2 SON HIDROGENO O UN RADICAL ALQUILO QUE TIENE DE 1 A 3 ATOMOS DE CARBONO O R1 Y R2 JUNTOS CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS FORMAN UN ANILLO HETEROCICLICO SATURADO QUE TIENE 4-5 ATOMOS DE CARBONO.
ES198686309449T 1985-12-06 1986-12-04 Profarmacos de rapamicina. Expired - Lifetime ES2032750T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/806,152 US4650803A (en) 1985-12-06 1985-12-06 Prodrugs of rapamycin

Publications (1)

Publication Number Publication Date
ES2032750T3 true ES2032750T3 (es) 1993-03-01

Family

ID=25193443

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686309449T Expired - Lifetime ES2032750T3 (es) 1985-12-06 1986-12-04 Profarmacos de rapamicina.

Country Status (16)

Country Link
US (1) US4650803A (es)
EP (1) EP0227355B1 (es)
JP (2) JPH0670066B2 (es)
KR (2) KR940004072B1 (es)
AT (1) ATE74134T1 (es)
AU (1) AU583439B2 (es)
CA (2) CA1273920A (es)
DE (1) DE3684574D1 (es)
DK (2) DK169409B1 (es)
ES (1) ES2032750T3 (es)
GB (1) GB2183647A (es)
GR (1) GR3004530T3 (es)
HU (1) HU198054B (es)
IE (1) IE64506B1 (es)
PT (1) PT83843B (es)
ZA (1) ZA869181B (es)

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PT83843A (en) 1987-01-01
US4650803A (en) 1987-03-17
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