CY1110284T1 - Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο - Google Patents

Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο

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Publication number
CY1110284T1
CY1110284T1 CY20101100056T CY101100056T CY1110284T1 CY 1110284 T1 CY1110284 T1 CY 1110284T1 CY 20101100056 T CY20101100056 T CY 20101100056T CY 101100056 T CY101100056 T CY 101100056T CY 1110284 T1 CY1110284 T1 CY 1110284T1
Authority
CY
Cyprus
Prior art keywords
amino
thaizoline
inducers
pyridyl
methyl
Prior art date
Application number
CY20101100056T
Other languages
English (en)
Inventor
Eric Bacque
Antony Bigot
Jean-Christophe Carry
Serge Mignani
Baptiste Ronan
Michel Tabart
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114508A external-priority patent/FR2832150B1/fr
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CY1110284T1 publication Critical patent/CY1110284T1/el

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

Η παρούσα εφεύρεση αφορά τη χρήση των παραγώγων 2-αμινο- 4- πυριδυλομεθυλο θειαζολίνης του τύπου (I) όπου το είτε R1 = R2 = C1, ή αλκύλιο(C1-C4), ή υδροξύ, ή το ή άλκοξυ (C1-C4) είτε τουλάχιστον ένα από τα δύο R1, R2 είναι υδρογόνο και το άλλο είναι μια ρίζα αλκυλίου (C1-C4), ένα υδροξύ, ένα άλκοξυ (C1-C4) ή ένα χλώριο ή τα φαρμακευτικώς αποδεκτά άλατα αυτών ως αναστολείς της επαγώγιμης συνθάσης NO.
CY20101100056T 2001-11-09 2010-01-20 Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο CY1110284T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0114508A FR2832150B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297802P 2002-01-30 2002-01-30
EP02793210A EP1450750B1 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-pyridylmethyl-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible

Publications (1)

Publication Number Publication Date
CY1110284T1 true CY1110284T1 (el) 2015-01-14

Family

ID=26213258

Family Applications (1)

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CY20101100056T CY1110284T1 (el) 2001-11-09 2010-01-20 Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο

Country Status (22)

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US (1) US6762196B2 (el)
EP (1) EP1450750B1 (el)
JP (1) JP4342309B2 (el)
CN (1) CN1288153C (el)
AT (1) ATE446295T1 (el)
BR (1) BR0206368A (el)
CA (1) CA2465877C (el)
CY (1) CY1110284T1 (el)
DE (1) DE60234117D1 (el)
DK (1) DK1450750T3 (el)
ES (1) ES2335090T3 (el)
HR (1) HRP20040402A2 (el)
HU (1) HUP0402033A2 (el)
IL (2) IL161843A0 (el)
MA (1) MA27143A1 (el)
MX (1) MXPA04004213A (el)
NO (1) NO20033131L (el)
PL (1) PL370267A1 (el)
PT (1) PT1450750E (el)
RU (1) RU2004117531A (el)
SI (1) SI1450750T1 (el)
WO (1) WO2003039446A2 (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240735A1 (de) * 2002-08-29 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung
CA2628074C (en) * 2005-10-25 2014-01-14 Shionogi & Co., Ltd. Aminodihydrothiazine derivative
MX2009011498A (es) 2007-04-24 2009-11-10 Shionogi & Co Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
BRPI0915500A2 (pt) 2008-06-13 2019-08-27 Shionogi & Co derivado heterocíclico contendo enxofre tendo atividade inibitória de beta secretase
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
WO2011071135A1 (ja) 2009-12-11 2011-06-16 塩野義製薬株式会社 オキサジン誘導体
US8927721B2 (en) 2010-10-29 2015-01-06 Shionogi & Co., Ltd. Naphthyridine derivative
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
JPWO2012147763A1 (ja) 2011-04-26 2014-07-28 塩野義製薬株式会社 オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
ES2129679T3 (es) * 1993-10-21 1999-06-16 Searle & Co Derivados que contienen el grupo amidino, utiles como inhibidores de la sintasa de oxido nitrico.
AU4149696A (en) * 1994-11-15 1996-06-06 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

Also Published As

Publication number Publication date
HRP20040402A2 (en) 2004-10-31
CA2465877A1 (fr) 2003-05-15
PL370267A1 (en) 2005-05-16
DK1450750T3 (da) 2010-03-08
CA2465877C (fr) 2009-12-29
IL161843A0 (en) 2005-11-20
BR0206368A (pt) 2004-02-10
IL161843A (en) 2011-08-31
US6762196B2 (en) 2004-07-13
CN1602311A (zh) 2005-03-30
NO20033131L (no) 2003-08-27
EP1450750B1 (fr) 2009-10-21
NO20033131D0 (no) 2003-07-08
ATE446295T1 (de) 2009-11-15
WO2003039446A2 (fr) 2003-05-15
EP1450750A2 (fr) 2004-09-01
US20030153605A1 (en) 2003-08-14
SI1450750T1 (sl) 2010-02-26
WO2003039446A3 (fr) 2003-11-27
HUP0402033A2 (hu) 2005-02-28
MXPA04004213A (es) 2004-07-08
CN1288153C (zh) 2006-12-06
PT1450750E (pt) 2010-01-18
RU2004117531A (ru) 2005-04-10
JP4342309B2 (ja) 2009-10-14
ES2335090T3 (es) 2010-03-22
DE60234117D1 (de) 2009-12-03
JP2005517634A (ja) 2005-06-16
MA27143A1 (fr) 2005-01-03

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