BR0206368A - Utilização de derivados de 2-amino-4-piridilmetil-tiazolina como inibidores de no-sintase induzìvel - Google Patents

Utilização de derivados de 2-amino-4-piridilmetil-tiazolina como inibidores de no-sintase induzìvel

Info

Publication number
BR0206368A
BR0206368A BR0206368-9A BR0206368A BR0206368A BR 0206368 A BR0206368 A BR 0206368A BR 0206368 A BR0206368 A BR 0206368A BR 0206368 A BR0206368 A BR 0206368A
Authority
BR
Brazil
Prior art keywords
pyridylmethyl
amino
inductively
synthase inhibitors
thiazoline derivatives
Prior art date
Application number
BR0206368-9A
Other languages
English (en)
Inventor
Eric Bacque
Serge Mignani
Baptiste Ronan
Michel Tabart
Antony Bingo
Jean-Cristophe Carry
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114508A external-priority patent/FR2832150B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0206368A publication Critical patent/BR0206368A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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Abstract

"UTILIZAçãO DE DERIVADOS DE 2-AMINO-4-PIRIDILMETIL-TIAZOLINA COMO INIBIDORES DE NO-SINTASE INDUZìVEL". A presente invenção se refere à utilização de derivados 2-amino-4-piridilmetil-tiazolina de fórmula (I) na qual ou R1 = R2 = CI, ou alquila (C1-C4), ou hidróxi; ou alcóxi (C1-C4) ou pelo menos um dos dois R1, R2 é um hidrogênio e o outro é um radical alquila (C1-C4), um hidróxi, um alcóxi (C1-C4) ou um cloro, ou seus sais farmaceuticamente aceitáveis como inibidores de NO-sintase induzível.
BR0206368-9A 2001-11-09 2002-11-07 Utilização de derivados de 2-amino-4-piridilmetil-tiazolina como inibidores de no-sintase induzìvel BR0206368A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0114508A FR2832150B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297802P 2002-01-30 2002-01-30
PCT/FR2002/003808 WO2003039446A2 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-pyridylmethyl-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible

Publications (1)

Publication Number Publication Date
BR0206368A true BR0206368A (pt) 2004-02-10

Family

ID=26213258

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0206368-9A BR0206368A (pt) 2001-11-09 2002-11-07 Utilização de derivados de 2-amino-4-piridilmetil-tiazolina como inibidores de no-sintase induzìvel

Country Status (22)

Country Link
US (1) US6762196B2 (pt)
EP (1) EP1450750B1 (pt)
JP (1) JP4342309B2 (pt)
CN (1) CN1288153C (pt)
AT (1) ATE446295T1 (pt)
BR (1) BR0206368A (pt)
CA (1) CA2465877C (pt)
CY (1) CY1110284T1 (pt)
DE (1) DE60234117D1 (pt)
DK (1) DK1450750T3 (pt)
ES (1) ES2335090T3 (pt)
HR (1) HRP20040402A2 (pt)
HU (1) HUP0402033A2 (pt)
IL (2) IL161843A0 (pt)
MA (1) MA27143A1 (pt)
MX (1) MXPA04004213A (pt)
NO (1) NO20033131L (pt)
PL (1) PL370267A1 (pt)
PT (1) PT1450750E (pt)
RU (1) RU2004117531A (pt)
SI (1) SI1450750T1 (pt)
WO (1) WO2003039446A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240735A1 (de) * 2002-08-29 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung
CN103936690B (zh) 2005-10-25 2016-06-08 盐野义制药株式会社 氨基二氢噻嗪衍生物
JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
EP2147914B1 (en) 2007-04-24 2014-06-04 Shionogi&Co., Ltd. Aminodihydrothiazine derivatives substituted with cyclic groups
ES2738123T3 (es) 2008-06-13 2020-01-20 Shionogi & Co Derivado heterocíclico que contiene azufre que tiene actividad inhibitoria de ß-secretasa
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
BR112012013854A2 (pt) 2009-12-11 2019-09-24 Shionogi & Co derivados de oxazina.
US8927721B2 (en) 2010-10-29 2015-01-06 Shionogi & Co., Ltd. Naphthyridine derivative
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
US8883779B2 (en) 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
CN1077886C (zh) * 1993-10-21 2002-01-16 G·D·瑟尔公司 用作一氧化一氮合酶抑制剂的脒基衍生物
AU4149696A (en) * 1994-11-15 1996-06-06 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

Also Published As

Publication number Publication date
CY1110284T1 (el) 2015-01-14
US6762196B2 (en) 2004-07-13
EP1450750A2 (fr) 2004-09-01
HUP0402033A2 (hu) 2005-02-28
NO20033131L (no) 2003-08-27
ATE446295T1 (de) 2009-11-15
US20030153605A1 (en) 2003-08-14
HRP20040402A2 (en) 2004-10-31
NO20033131D0 (no) 2003-07-08
CN1602311A (zh) 2005-03-30
CA2465877C (fr) 2009-12-29
PL370267A1 (en) 2005-05-16
CA2465877A1 (fr) 2003-05-15
JP4342309B2 (ja) 2009-10-14
WO2003039446A3 (fr) 2003-11-27
ES2335090T3 (es) 2010-03-22
CN1288153C (zh) 2006-12-06
SI1450750T1 (sl) 2010-02-26
DK1450750T3 (da) 2010-03-08
IL161843A0 (en) 2005-11-20
EP1450750B1 (fr) 2009-10-21
IL161843A (en) 2011-08-31
JP2005517634A (ja) 2005-06-16
DE60234117D1 (de) 2009-12-03
PT1450750E (pt) 2010-01-18
MA27143A1 (fr) 2005-01-03
RU2004117531A (ru) 2005-04-10
WO2003039446A2 (fr) 2003-05-15
MXPA04004213A (es) 2004-07-08

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