BR0206363A - Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel - Google Patents
Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvelInfo
- Publication number
- BR0206363A BR0206363A BR0206363-8A BR0206363A BR0206363A BR 0206363 A BR0206363 A BR 0206363A BR 0206363 A BR0206363 A BR 0206363A BR 0206363 A BR0206363 A BR 0206363A
- Authority
- BR
- Brazil
- Prior art keywords
- amino
- heteroarylethylthiazoline
- synthase
- deerivates
- inducibly
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
"UTILIZAçãO DE DERIVADOS DE 2-AMINO-4-HETEROARILETILTIAZOLINA COMO INIBIDORES DE NO-SINTASE INDUTìVEL". A presente invenção refere-se à utilização de derivados 2-amino-4-heteroariletil-tiazolina de fórmula (I) na qual Het representa um radical tienila, pirimidila, piridila ou tiazol ou seus sais farmaceuticamente aceitáveis como inibidores de NO-sintase indutível.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0114509A FR2832151B1 (fr) | 2001-11-09 | 2001-11-09 | Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible |
US35297702P | 2002-01-30 | 2002-01-30 | |
PCT/FR2002/003809 WO2003040142A1 (fr) | 2001-11-09 | 2002-11-07 | Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206363A true BR0206363A (pt) | 2003-12-23 |
Family
ID=26213259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206363-8A BR0206363A (pt) | 2001-11-09 | 2002-11-07 | Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel |
Country Status (19)
Country | Link |
---|---|
US (1) | US6872740B2 (pt) |
EP (1) | EP1446402B1 (pt) |
JP (1) | JP4365681B2 (pt) |
AT (1) | ATE308541T1 (pt) |
AU (1) | AU2002358874B2 (pt) |
BR (1) | BR0206363A (pt) |
CA (1) | CA2465691C (pt) |
DE (1) | DE60207104T2 (pt) |
DK (1) | DK1446402T3 (pt) |
ES (1) | ES2250731T3 (pt) |
HR (1) | HRP20040401A2 (pt) |
HU (1) | HUP0402038A2 (pt) |
IL (2) | IL161842A0 (pt) |
MA (1) | MA27077A1 (pt) |
MX (1) | MXPA04003766A (pt) |
NO (1) | NO20033130L (pt) |
PL (1) | PL370322A1 (pt) |
RU (1) | RU2004117525A (pt) |
WO (1) | WO2003040142A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0206354A (pt) * | 2001-11-09 | 2003-12-23 | Aventis Pharma Sa | Utilização de derivados de 2-amino-tiazolina como inibidores de no-sintase indutìvel |
ES2537898T3 (es) * | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
JP5383484B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | 環式基で置換されたアミノジヒドロチアジン誘導体 |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
BR112012013854A2 (pt) | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
WO2012057247A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
CN107205973A (zh) | 2014-10-24 | 2017-09-26 | 韩国海洋研究院 | 用于预防或治疗神经变性疾病的含有Ramalin的组合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL107771A0 (en) * | 1992-11-27 | 1994-02-27 | Wellcome Found | Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation |
RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
AU4149696A (en) * | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
-
2002
- 2002-11-07 MX MXPA04003766A patent/MXPA04003766A/es active IP Right Grant
- 2002-11-07 WO PCT/FR2002/003809 patent/WO2003040142A1/fr active IP Right Grant
- 2002-11-07 AT AT02793211T patent/ATE308541T1/de active
- 2002-11-07 PL PL02370322A patent/PL370322A1/xx unknown
- 2002-11-07 JP JP2003542188A patent/JP4365681B2/ja not_active Expired - Fee Related
- 2002-11-07 EP EP02793211A patent/EP1446402B1/fr not_active Expired - Lifetime
- 2002-11-07 DE DE60207104T patent/DE60207104T2/de not_active Expired - Lifetime
- 2002-11-07 CA CA2465691A patent/CA2465691C/fr not_active Expired - Fee Related
- 2002-11-07 RU RU2004117525/04A patent/RU2004117525A/ru not_active Application Discontinuation
- 2002-11-07 IL IL16184202A patent/IL161842A0/xx unknown
- 2002-11-07 DK DK02793211T patent/DK1446402T3/da active
- 2002-11-07 BR BR0206363-8A patent/BR0206363A/pt not_active Application Discontinuation
- 2002-11-07 HU HU0402038A patent/HUP0402038A2/hu unknown
- 2002-11-07 ES ES02793211T patent/ES2250731T3/es not_active Expired - Lifetime
- 2002-11-07 AU AU2002358874A patent/AU2002358874B2/en not_active Ceased
- 2002-11-08 US US10/291,110 patent/US6872740B2/en not_active Expired - Fee Related
-
2003
- 2003-07-08 NO NO20033130A patent/NO20033130L/no unknown
-
2004
- 2004-04-22 MA MA27645A patent/MA27077A1/fr unknown
- 2004-05-06 HR HR20040401A patent/HRP20040401A2/hr not_active Application Discontinuation
- 2004-05-06 IL IL161842A patent/IL161842A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20033130L (no) | 2003-08-27 |
DE60207104D1 (de) | 2005-12-08 |
HUP0402038A2 (hu) | 2005-01-28 |
HRP20040401A2 (en) | 2004-10-31 |
US20030225140A1 (en) | 2003-12-04 |
ES2250731T3 (es) | 2006-04-16 |
US6872740B2 (en) | 2005-03-29 |
AU2002358874B2 (en) | 2007-09-06 |
WO2003040142A1 (fr) | 2003-05-15 |
CA2465691A1 (fr) | 2003-05-15 |
JP4365681B2 (ja) | 2009-11-18 |
DK1446402T3 (da) | 2006-03-06 |
JP2005509651A (ja) | 2005-04-14 |
RU2004117525A (ru) | 2005-04-20 |
MA27077A1 (fr) | 2004-12-20 |
EP1446402A1 (fr) | 2004-08-18 |
MXPA04003766A (es) | 2004-07-29 |
CA2465691C (fr) | 2011-07-19 |
NO20033130D0 (no) | 2003-07-08 |
IL161842A0 (en) | 2005-11-20 |
PL370322A1 (en) | 2005-05-16 |
DE60207104T2 (de) | 2006-07-13 |
ATE308541T1 (de) | 2005-11-15 |
IL161842A (en) | 2010-12-30 |
EP1446402B1 (fr) | 2005-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0507818A (pt) | composto e métodos de inibição | |
BR0206363A (pt) | Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel | |
GT200000167A (es) | Nuevos derivados de biarileter utiles como inhibidores de la recaptacion de monoaminas. | |
NO20070555L (no) | Kinazolinonderivater som parp-inhibitorer | |
ATE300540T1 (de) | Imidazopyridin-derivate | |
NO20070526L (no) | Kinazolindionderivater som parp-inhibitorer | |
BRPI0514372A (pt) | inibidores de tiazol de frutose 1, 6-bisfosfatase | |
NO20070557L (no) | Ftalazinderivater som PARP-inhibitorer | |
NO20012567L (no) | Azepinoindolderivater, fremstilling og anvendelse derav | |
DE60322359D1 (de) | Imidazopyridinderivate als kinaseinhibitoren | |
BR0205890A (pt) | Pirazolopirimidinas como agentes terapêuticos | |
BR0205889A (pt) | Pirazolopirimidinas como agentes tepapêuticos | |
EP1180518A4 (en) | 5-PYRIDYLE-1,3-AZOLE COMPOUNDS, THEIR MANUFACTURING PROCESS AND THEIR USE | |
EP1854789A4 (en) | CHINAZOLINE DERIVATIVE WITH TYROSINE KINASE HEMMENDER EFFECT | |
NO20001781L (no) | 3-amino-3-arylpropan-1-og lignende-derivater, deres fremstilling og anvendelse | |
TR200001452T2 (tr) | Bifenilamidin türevleri. | |
BR0206354A (pt) | Utilização de derivados de 2-amino-tiazolina como inibidores de no-sintase indutìvel | |
NO20023001L (no) | Substituerte piperazinderivater som MTP inhibitorer | |
BR0206368A (pt) | Utilização de derivados de 2-amino-4-piridilmetil-tiazolina como inibidores de no-sintase induzìvel | |
TW200626130A (en) | 5-membered heterocycle derivatives | |
NO20076037L (no) | Nye tiazolidinoner uten basisk nitrogen, deres fremstilling og anvendelse som farmasoytiske midler | |
ATE485280T1 (de) | Pyrimidylderivate als proteinkinaseinhibitoren | |
BR0111986A (pt) | Derivados de 2-aminotiazolina e sua utilização como inibidores de no-sintase | |
BRPI0517643A (pt) | derivados de ácido piridono-carboxìlico ou seus sais | |
NO20081818L (no) | Arylsulfonylkromaner som 5-HT6-inhibitorer - indolylmaleimidderivater som protein kinaseinhibitorer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |