BR0206363A - Use of 2-amino-4-heteroarylethylthiazoline deerivates as inducibly inhibited no synthase - Google Patents

Use of 2-amino-4-heteroarylethylthiazoline deerivates as inducibly inhibited no synthase

Info

Publication number
BR0206363A
BR0206363A BR0206363-8A BR0206363A BR0206363A BR 0206363 A BR0206363 A BR 0206363A BR 0206363 A BR0206363 A BR 0206363A BR 0206363 A BR0206363 A BR 0206363A
Authority
BR
Brazil
Prior art keywords
amino
heteroarylethylthiazoline
synthase
deerivates
inducibly
Prior art date
Application number
BR0206363-8A
Other languages
Portuguese (pt)
Inventor
Eric Bacque
Antony Bigot
Jean-Christophe Carry
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114509A external-priority patent/FR2832151B1/en
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0206363A publication Critical patent/BR0206363A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

"UTILIZAçãO DE DERIVADOS DE 2-AMINO-4-HETEROARILETILTIAZOLINA COMO INIBIDORES DE NO-SINTASE INDUTìVEL". A presente invenção refere-se à utilização de derivados 2-amino-4-heteroariletil-tiazolina de fórmula (I) na qual Het representa um radical tienila, pirimidila, piridila ou tiazol ou seus sais farmaceuticamente aceitáveis como inibidores de NO-sintase indutível."USE OF 2-AMINO-4-HETEROARILETILTIAZOLINE DERIVATIVES AS INDUCIBLE NON SYNTASE INHIBITORS". The present invention relates to the use of 2-amino-4-heteroarylethylthiazoline derivatives of formula (I) wherein Het represents a thienyl, pyrimidyl, pyridyl or thiazole radical or pharmaceutically acceptable salts thereof as inducible NO synthase inhibitors.

BR0206363-8A 2001-11-09 2002-11-07 Use of 2-amino-4-heteroarylethylthiazoline deerivates as inducibly inhibited no synthase BR0206363A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0114509A FR2832151B1 (en) 2001-11-09 2001-11-09 USE OF 2-AMINO-4-HETEROARYLETHYL-THIAZOLINE DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS
US35297702P 2002-01-30 2002-01-30
PCT/FR2002/003809 WO2003040142A1 (en) 2001-11-09 2002-11-07 2-amino-4-heteroarylethyl thiazoline derivatives and their use an inhibitors of inducible no-synthase

Publications (1)

Publication Number Publication Date
BR0206363A true BR0206363A (en) 2003-12-23

Family

ID=26213259

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0206363-8A BR0206363A (en) 2001-11-09 2002-11-07 Use of 2-amino-4-heteroarylethylthiazoline deerivates as inducibly inhibited no synthase

Country Status (19)

Country Link
US (1) US6872740B2 (en)
EP (1) EP1446402B1 (en)
JP (1) JP4365681B2 (en)
AT (1) ATE308541T1 (en)
AU (1) AU2002358874B2 (en)
BR (1) BR0206363A (en)
CA (1) CA2465691C (en)
DE (1) DE60207104T2 (en)
DK (1) DK1446402T3 (en)
ES (1) ES2250731T3 (en)
HR (1) HRP20040401A2 (en)
HU (1) HUP0402038A2 (en)
IL (2) IL161842A0 (en)
MA (1) MA27077A1 (en)
MX (1) MXPA04003766A (en)
NO (1) NO20033130L (en)
PL (1) PL370322A1 (en)
RU (1) RU2004117525A (en)
WO (1) WO2003040142A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0206354A (en) * 2001-11-09 2003-12-23 Aventis Pharma Sa Use of 2-amino thiazoline derivatives as inducibly inducible synthase inhibitors
ES2537898T3 (en) * 2005-10-25 2015-06-15 Shionogi & Co., Ltd. Aminothiazolidine and aminotetrahydrotiazepine derivatives as BACE 1 inhibitors
JP5383484B2 (en) 2007-04-24 2014-01-08 塩野義製薬株式会社 Aminodihydrothiazine derivatives substituted with cyclic groups
JP5383483B2 (en) 2007-04-24 2014-01-08 塩野義製薬株式会社 Pharmaceutical composition for the treatment of Alzheimer's disease
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
JPWO2010047372A1 (en) 2008-10-22 2012-03-22 塩野義製薬株式会社 2-Aminopyrimidin-4-one and 2-aminopyridine derivatives having BACE1 inhibitory activity
BR112012013854A2 (en) 2009-12-11 2019-09-24 Shionogi & Co oxazine derivatives.
JP5816630B2 (en) 2010-10-29 2015-11-18 塩野義製薬株式会社 Naphthyridine derivatives
WO2012057247A1 (en) 2010-10-29 2012-05-03 塩野義製薬株式会社 Fused aminodihydropyrimidine derivative
WO2012147763A1 (en) 2011-04-26 2012-11-01 塩野義製薬株式会社 Oxazine derivative and bace 1 inhibitor containing same
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
CN107205973A (en) 2014-10-24 2017-09-26 韩国海洋研究院 The composition containing Ramalin for preventing or treating neurodegenerative disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
RU2136661C1 (en) * 1993-10-21 1999-09-10 Джи Ди Сирл энд Ко. Amidino-derivatives, their use and pharmaceutical composition
AU4149696A (en) * 1994-11-15 1996-06-06 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (en) * 2000-06-09 2004-04-23 Aventis Pharma Sa USE OF 2-AMINOTHIAZOLINE DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS

Also Published As

Publication number Publication date
NO20033130L (en) 2003-08-27
DE60207104D1 (en) 2005-12-08
HUP0402038A2 (en) 2005-01-28
HRP20040401A2 (en) 2004-10-31
US20030225140A1 (en) 2003-12-04
ES2250731T3 (en) 2006-04-16
US6872740B2 (en) 2005-03-29
AU2002358874B2 (en) 2007-09-06
WO2003040142A1 (en) 2003-05-15
CA2465691A1 (en) 2003-05-15
JP4365681B2 (en) 2009-11-18
DK1446402T3 (en) 2006-03-06
JP2005509651A (en) 2005-04-14
RU2004117525A (en) 2005-04-20
MA27077A1 (en) 2004-12-20
EP1446402A1 (en) 2004-08-18
MXPA04003766A (en) 2004-07-29
CA2465691C (en) 2011-07-19
NO20033130D0 (en) 2003-07-08
IL161842A0 (en) 2005-11-20
PL370322A1 (en) 2005-05-16
DE60207104T2 (en) 2006-07-13
ATE308541T1 (en) 2005-11-15
IL161842A (en) 2010-12-30
EP1446402B1 (en) 2005-11-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.