AU4149696A - Substituted heterocycles as inhibitors of nitric oxide synthase - Google Patents

Substituted heterocycles as inhibitors of nitric oxide synthase

Info

Publication number
AU4149696A
AU4149696A AU41496/96A AU4149696A AU4149696A AU 4149696 A AU4149696 A AU 4149696A AU 41496/96 A AU41496/96 A AU 41496/96A AU 4149696 A AU4149696 A AU 4149696A AU 4149696 A AU4149696 A AU 4149696A
Authority
AU
Australia
Prior art keywords
inhibitors
nitric oxide
oxide synthase
substituted heterocycles
heterocycles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU41496/96A
Inventor
Stephan K Grant
Ravindra N Guthikonda
Malcolm Maccoss
Hongbo Qi
Shrenik K. Shah
Kothandaraman Shankaran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4149696A publication Critical patent/AU4149696A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU41496/96A 1994-11-15 1995-11-13 Substituted heterocycles as inhibitors of nitric oxide synthase Abandoned AU4149696A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33961894A 1994-11-15 1994-11-15
US339618 1994-11-15
PCT/US1995/014512 WO1996014842A1 (en) 1994-11-15 1995-11-13 Substituted heterocycles as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
AU4149696A true AU4149696A (en) 1996-06-06

Family

ID=23329864

Family Applications (1)

Application Number Title Priority Date Filing Date
AU41496/96A Abandoned AU4149696A (en) 1994-11-15 1995-11-13 Substituted heterocycles as inhibitors of nitric oxide synthase

Country Status (2)

Country Link
AU (1) AU4149696A (en)
WO (1) WO1996014842A1 (en)

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RU2136661C1 (en) * 1993-10-21 1999-09-10 Джи Ди Сирл энд Ко. Amidino-derivatives, their use and pharmaceutical composition
DE19530870A1 (en) * 1994-12-14 1996-06-20 Japan Tobacco Inc New 2-amino-1,3-thiazine and -thiazepine derivs.
US6011028A (en) * 1995-04-20 2000-01-04 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5872124A (en) * 1996-07-31 1999-02-16 Thomas Jefferson University Treatment of diseases of the central nervous system using uric acid as a scavenger of peroxynitrite
US6432947B1 (en) 1997-02-19 2002-08-13 Berlex Laboratories, Inc. N-heterocyclic derivatives as NOS inhibitors
US6110930A (en) 1997-04-10 2000-08-29 Ono Pharmaceutical Co., Ltd. Condensed piperidine compound
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
AU8647198A (en) * 1997-08-12 1999-03-01 Chugai Seiyaku Kabushiki Kaisha Remedies for diseases associated with bone resorption
JPH11217330A (en) 1998-01-30 1999-08-10 Sumitomo Pharmaceut Co Ltd Neurotrophic factor secretagogue
CA2333691A1 (en) 1998-06-10 1999-12-16 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6353006B1 (en) 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
SE9901530D0 (en) * 1999-04-28 1999-04-28 Astra Pharma Prod Novel compounds
US6525051B2 (en) 2000-03-27 2003-02-25 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
FR2810036B1 (en) * 2000-06-09 2004-04-23 Aventis Pharma Sa 4,5-DIHYDRO-1,3-THIAZOL-2-YLAMINE DERIVATIVES, THEIR PREPARATION AND THE PHAMARCEUTICAL COMPOSITIONS CONTAINING THEM
US6451821B1 (en) 2000-06-09 2002-09-17 Aventis Pharma S.A. Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase
FR2832152A1 (en) * 2001-11-09 2003-05-16 Aventis Pharma Sa New 2-amino-thiazoline derivatives having inducible NO-synthase inhibiting activity, useful for treating Parkinson's, cerebral disorders, migraines, depression, diabetes
US6420566B2 (en) 2000-06-09 2002-07-16 Aventis Pharma S.A. Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof
FR2810037B1 (en) * 2000-06-09 2004-04-23 Aventis Pharma Sa USE OF 2-AMINOTHIAZOLINE DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
EP1426060A4 (en) * 2001-09-10 2004-12-01 Ono Pharmaceutical Co Remedies for allergic diseases
ES2256583T3 (en) 2001-11-09 2006-07-16 Aventis Pharma S.A. DERIVATIVES OF 2-AMINO-TIAZOLINE AND ITS USE AS INHIBITORS OF THE INDUCIBLE NON-SYNTHEASE.
FR2832151B1 (en) * 2001-11-09 2004-12-17 Aventis Pharma Sa USE OF 2-AMINO-4-HETEROARYLETHYL-THIAZOLINE DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS
FR2832150B1 (en) * 2001-11-09 2004-07-16 Aventis Pharma Sa USE OF 2-AMINO-4-PYRIDYLMETHYL-THIAZOLINE DERIVATIVES AS INDUCTIBLE NO-SYNTHASE INHIBITORS
HUP0402033A2 (en) 2001-11-09 2005-02-28 Aventis Pharma S.A. Use of 2-amino-4-pyridylmethyl-thiazoline derivatives as inhibitors of inducible no-synthase, process for their preparation and pharmaceutical compositions containing them
IL161842A0 (en) 2001-11-09 2005-11-20 Aventis Pharma Sa 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase
WO2003075922A1 (en) * 2002-03-14 2003-09-18 Dainippon Pharmaceutical Co., Ltd. Nitrogen monoxide synthase inhibitors
US6982259B2 (en) 2002-04-30 2006-01-03 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
CA2628074C (en) 2005-10-25 2014-01-14 Shionogi & Co., Ltd. Aminodihydrothiazine derivative
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co Pharmaceutical composition for treatment of alzheimer's disease
CA2683887A1 (en) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives substituted with a cyclic group having inhibitory activity against production of amyloid beta protein
DK2233474T3 (en) 2008-01-18 2015-10-19 Eisai R&D Man Co Ltd Concentrated aminodihydrothiazinderivat
TWI431004B (en) 2008-05-02 2014-03-21 Lilly Co Eli Bace inhibitors
JP5490692B2 (en) 2008-06-13 2014-05-14 塩野義製薬株式会社 Sulfur-containing heterocyclic derivatives having β-secretase inhibitory action
WO2010041964A1 (en) * 2008-10-09 2010-04-15 Victoria Link Limited Methods for the preparation of alkenylamines, cyclic carbamates or dithiocarbamates, and aminoalcohols or aminothiols
EP2360155A4 (en) 2008-10-22 2012-06-20 Shionogi & Co 2-aminopyridin-4-one and 2-aminopyridine derivative both having bace1-inhibiting activity
EP2511268B2 (en) 2009-12-11 2021-02-17 Shionogi & Co., Ltd. Oxazine derivative
EP2634186A4 (en) 2010-10-29 2014-03-26 Shionogi & Co Naphthyridine derivative
US9018219B2 (en) 2010-10-29 2015-04-28 Shionogi & Co., Ltd. Fused aminodihydropyrimidine derivative
EP2703399A4 (en) 2011-04-26 2014-10-15 Shionogi & Co Oxazine derivative and bace 1 inhibitor containing same
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
JP6162820B2 (en) * 2012-12-19 2017-07-12 ファイザー・インク Carbocyclic and heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds
WO2014125394A1 (en) * 2013-02-13 2014-08-21 Pfizer Inc. HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
US9233981B1 (en) * 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
JP7321534B2 (en) * 2018-03-16 2023-08-07 脳科学香料株式会社 Preventive or therapeutic agent for hypoxic injury, ischemia-reperfusion injury or inflammation, cytoprotective agent for transplantation, and biological preservation agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533094A (en) * 1992-11-27 1994-06-22 Wellcome Foundation Limited, The Enzyme inhibitors

Also Published As

Publication number Publication date
WO1996014842A1 (en) 1996-05-23

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