AU4515896A - Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase - Google Patents

Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase

Info

Publication number
AU4515896A
AU4515896A AU45158/96A AU4515896A AU4515896A AU 4515896 A AU4515896 A AU 4515896A AU 45158/96 A AU45158/96 A AU 45158/96A AU 4515896 A AU4515896 A AU 4515896A AU 4515896 A AU4515896 A AU 4515896A
Authority
AU
Australia
Prior art keywords
pyridines
acylamino
inhibitors
substituted
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU45158/96A
Inventor
Philippe L. Durette
Ravindra K Guthikonda
William K. Hagmann
Malcolm Maccoss
Shrenik K. Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4515896A publication Critical patent/AU4515896A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
AU45158/96A 1994-12-12 1995-12-08 Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase Abandoned AU4515896A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35385994A 1994-12-12 1994-12-12
US353859 1994-12-12
PCT/US1995/016158 WO1996018617A1 (en) 1994-12-12 1995-12-08 Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
AU4515896A true AU4515896A (en) 1996-07-03

Family

ID=23390892

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45158/96A Abandoned AU4515896A (en) 1994-12-12 1995-12-08 Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase

Country Status (2)

Country Link
AU (1) AU4515896A (en)
WO (1) WO1996018617A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627310A1 (en) * 1996-06-27 1998-01-02 Schering Ag Imidazole derivatives as nitric oxide synthase inhibitors
IT1298159B1 (en) * 1997-01-28 1999-12-20 Hoffmann La Roche DERIVATIVES OF A 5-AROYLNAPHTHALENE
WO1999011621A2 (en) * 1997-09-03 1999-03-11 American Home Products Corporation Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
GB9808015D0 (en) * 1998-04-15 1998-06-17 United Medical And Dental Scho Protection of the nervous system from the effects of inflammatory disease
SE9803773D0 (en) * 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
GB9903404D0 (en) * 1999-02-16 1999-04-07 Angiogene Pharm Ltd Methods of treatment and compositions useful for the treatment of diseases involving angiogenesis
CN1347417A (en) 1999-03-09 2002-05-01 法玛西雅厄普约翰美国公司 4-oxo-4,7-dihydro-thieno [2,3-b] pyridine-5-carboxamides as antiviral agent
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
CA2452431A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-thioxo-4,7-dihydro-thieno¬2,3-b|pyridine-5-carboxamides as antiviral agents
AR038118A1 (en) 2002-01-14 2004-12-29 Upjohn Co COMPOUNDS DERIVED FROM ACID BENCINAMIDE 7-OXO-4,7-DIHIDROTIEN [2,3-B [PIRIDIN-6-CARBOXYLIC 3-REPLACED WHICH ARE USEFUL AS ANTIVIRAL
AR038117A1 (en) 2002-01-14 2004-12-29 Upjohn Co ANTIVIRAL AGENTS DERIVED FROM 4- OXO-4,7 -DIHYDROFIDE [2,3-B] PIRIDIN-5-CARBOXAMIDA
AR038294A1 (en) 2002-01-14 2005-01-12 Upjohn Co OXOTIENE (3,2-B) PYRIDINCARBOXAMIDS AS ANTIVIRAL AGENTS
SE0300906D0 (en) * 2003-03-31 2003-03-31 Astrazeneca Ab Novel compounds
SE0300907D0 (en) * 2003-03-31 2003-03-31 Astrazeneca Ab Novel compounds
KR20070026845A (en) 2004-07-23 2007-03-08 화이자 인코포레이티드 Pyridine derivatives
WO2007022946A1 (en) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclic compounds and their use as binding partners for 5-ht5 receptors
CA2684105C (en) 2007-05-03 2011-09-06 Pfizer Limited Pyridine derivatives
PL2195312T3 (en) 2007-10-09 2013-04-30 Merck Patent Gmbh Pyridine derivatives useful as glucokinase activators
JP6936796B2 (en) 2015-07-06 2021-09-22 ロダン・セラピューティクス，インコーポレーテッド Histone deacetylase heterohalo inhibitor
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
MD3570834T2 (en) 2017-01-11 2022-04-30 Alkermes Inc Bicyclic inhibitors of histone deacetylase
WO2019018562A1 (en) 2017-07-19 2019-01-24 Ideaya Biosciences, Inc. AMIDO COMPOUNDS AS AhR MODULATORS
PT3664802T (en) 2017-08-07 2022-05-24 Alkermes Inc Bicyclic inhibitors of histone deacetylase
WO2023176554A1 (en) * 2022-03-14 2023-09-21 国立大学法人東北大学 Cognitive-function-improving agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012165A2 (en) * 1992-11-27 1994-06-09 The Wellcome Foundation Limited Enzyme inhibitors
JPH08504798A (en) * 1992-12-18 1996-05-21 ザ ウエルカム ファウンデーション リミテッド Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors

Also Published As

Publication number Publication date
WO1996018617A1 (en) 1996-06-20

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