BR0206354A - Utilização de derivados de 2-amino-tiazolina como inibidores de no-sintase indutìvel - Google Patents
Utilização de derivados de 2-amino-tiazolina como inibidores de no-sintase indutìvelInfo
- Publication number
- BR0206354A BR0206354A BR0206354-9A BR0206354A BR0206354A BR 0206354 A BR0206354 A BR 0206354A BR 0206354 A BR0206354 A BR 0206354A BR 0206354 A BR0206354 A BR 0206354A
- Authority
- BR
- Brazil
- Prior art keywords
- synthase inhibitors
- inducibly
- thiazoline derivatives
- inducible
- amino
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- REGFWZVTTFGQOJ-UHFFFAOYSA-N 4,5-dihydro-1,3-thiazol-2-amine Chemical class NC1=NCCS1 REGFWZVTTFGQOJ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- JHXOAXMCYMGJLQ-UHFFFAOYSA-N 2,3-dihydro-1,3-thiazol-2-amine Chemical class NC1NC=CS1 JHXOAXMCYMGJLQ-UHFFFAOYSA-N 0.000 abstract 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 1
- 125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
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Abstract
"UTILIZAçãO DE DERIVADOS DE 2-AMINO-TIAZOLINA COMO INIBIDORES DE NO-SINTASE INDUTìVEL". A presente invenção refere-se a utilização de derivados 2-amino-4-tiazolina de fórmula (I) na qual ou Y e um metileno (CH~ 2~) e X é escolhido dentre os seguintes grupamentos: O, NH, N-Alquila (C1-C4), N-Bn, N-Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pirimidila, N-5-pirimidila, S, SO, SO~ 2~ CH~ 2~ ou CHPh; ou Y é um carbóxi (C=O) e X é escolhido dentre os seguintes grupamentos: NH, N-Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pirimidila ou N-5 pirimidila; ou seus sais farmaceuticamente aceitáveis, como inibidores de NO-sintase indutível.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0114510A FR2832152A1 (fr) | 2001-11-09 | 2001-11-09 | Utilisation de derives de 2-amino-thiazoline comme inhibiteurs de no-synthase inductible |
US35279702P | 2002-01-30 | 2002-01-30 | |
PCT/FR2002/003810 WO2003040115A1 (fr) | 2001-11-09 | 2002-11-07 | Derives de 2-amino-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206354A true BR0206354A (pt) | 2003-12-23 |
Family
ID=26213260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206354-9A BR0206354A (pt) | 2001-11-09 | 2002-11-07 | Utilização de derivados de 2-amino-tiazolina como inibidores de no-sintase indutìvel |
Country Status (20)
Country | Link |
---|---|
US (4) | US6699867B2 (pt) |
EP (1) | EP1446393B1 (pt) |
JP (1) | JP2005526005A (pt) |
CN (1) | CN1314674C (pt) |
AT (1) | ATE319693T1 (pt) |
BR (1) | BR0206354A (pt) |
CA (2) | CA2669810A1 (pt) |
DE (1) | DE60209806T2 (pt) |
DK (1) | DK1446393T3 (pt) |
ES (1) | ES2256583T3 (pt) |
HR (1) | HRP20040400A2 (pt) |
HU (1) | HUP0402037A2 (pt) |
IL (2) | IL161841A0 (pt) |
MA (1) | MA27078A1 (pt) |
MX (1) | MXPA04003695A (pt) |
NO (1) | NO20033129L (pt) |
PL (1) | PL370324A1 (pt) |
PT (1) | PT1446393E (pt) |
RU (1) | RU2004117526A (pt) |
WO (1) | WO2003040115A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003040115A1 (fr) * | 2001-11-09 | 2003-05-15 | Aventis Pharma S.A. | Derives de 2-amino-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
BRPI0617852A2 (pt) | 2005-10-25 | 2011-08-09 | Shionogi & Co | compostos derivados de aminodi-hidrotiazina assim como composições contendo os mesmos |
WO2008133273A1 (ja) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | アルツハイマー症治療用医薬組成物 |
AU2008245082B8 (en) | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
WO2009151098A1 (ja) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
AU2011321427A1 (en) | 2010-10-29 | 2013-05-02 | Shionogi & Co., Ltd. | Naphthyridine derivative |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
JPWO2012147763A1 (ja) | 2011-04-26 | 2014-07-28 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
EP2869903B1 (en) | 2012-07-06 | 2018-11-28 | 3-D Matrix Ltd. | Fill-finish process for peptide solutions |
EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
US8865700B2 (en) * | 2012-12-20 | 2014-10-21 | Avon Products, Inc. | Collagen stimulators and their use in the treatment of skin |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0278530A3 (de) * | 1980-08-30 | 1989-08-02 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
IL87614A0 (en) | 1987-09-16 | 1989-01-31 | Abbott Lab | Peptidylheterocycles |
US5066662A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors |
JPH08503940A (ja) * | 1992-11-27 | 1996-04-30 | ザ ウエルカム ファウンデーション リミテッド | 酵素阻害薬 |
ATE177078T1 (de) * | 1993-10-21 | 1999-03-15 | Searle & Co | Amidino-derivate als no-synthetase inhibitoren |
AU4149696A (en) * | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
AR016751A1 (es) | 1996-11-22 | 2001-08-01 | Athena Neurosciences Inc | Metodo para inhibir la liberacion del peptido beta-amiloide en una celula, composicion farmaceutica y compuestos utiles en dicho metodo |
US6451821B1 (en) * | 2000-06-09 | 2002-09-17 | Aventis Pharma S.A. | Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase |
FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
WO2003040115A1 (fr) * | 2001-11-09 | 2003-05-15 | Aventis Pharma S.A. | Derives de 2-amino-thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
US6420566B2 (en) * | 2000-06-09 | 2002-07-16 | Aventis Pharma S.A. | Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof |
DK1446402T3 (da) * | 2001-11-09 | 2006-03-06 | Aventis Pharma Sa | 2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase |
US7361681B2 (en) * | 2003-03-28 | 2008-04-22 | Sygnis Bioscience Gmbh & Co. Kg | Method of treating amytrophic lateral sclerosis using melatonin |
-
2002
- 2002-11-07 WO PCT/FR2002/003810 patent/WO2003040115A1/fr active IP Right Grant
- 2002-11-07 PT PT02796839T patent/PT1446393E/pt unknown
- 2002-11-07 DE DE60209806T patent/DE60209806T2/de not_active Expired - Fee Related
- 2002-11-07 CN CNB028245148A patent/CN1314674C/zh not_active Expired - Fee Related
- 2002-11-07 MX MXPA04003695A patent/MXPA04003695A/es active IP Right Grant
- 2002-11-07 PL PL02370324A patent/PL370324A1/xx unknown
- 2002-11-07 RU RU2004117526/04A patent/RU2004117526A/ru not_active Application Discontinuation
- 2002-11-07 AT AT02796839T patent/ATE319693T1/de not_active IP Right Cessation
- 2002-11-07 CA CA002669810A patent/CA2669810A1/fr not_active Abandoned
- 2002-11-07 JP JP2003542161A patent/JP2005526005A/ja active Pending
- 2002-11-07 CA CA002465695A patent/CA2465695A1/fr not_active Abandoned
- 2002-11-07 IL IL16184102A patent/IL161841A0/xx active IP Right Grant
- 2002-11-07 BR BR0206354-9A patent/BR0206354A/pt not_active IP Right Cessation
- 2002-11-07 EP EP02796839A patent/EP1446393B1/fr not_active Expired - Lifetime
- 2002-11-07 ES ES02796839T patent/ES2256583T3/es not_active Expired - Lifetime
- 2002-11-07 HU HU0402037A patent/HUP0402037A2/hu unknown
- 2002-11-07 DK DK02796839T patent/DK1446393T3/da active
- 2002-11-08 US US10/291,084 patent/US6699867B2/en not_active Expired - Fee Related
-
2003
- 2003-07-08 NO NO20033129A patent/NO20033129L/no unknown
-
2004
- 2004-01-26 US US10/764,853 patent/US6953796B2/en not_active Expired - Fee Related
- 2004-04-22 MA MA27646A patent/MA27078A1/fr unknown
- 2004-05-06 HR HR20040400A patent/HRP20040400A2/hr not_active Application Discontinuation
- 2004-05-06 IL IL161841A patent/IL161841A/en not_active IP Right Cessation
-
2005
- 2005-08-10 US US11/200,713 patent/US7227022B2/en not_active Expired - Fee Related
-
2007
- 2007-04-30 US US11/742,048 patent/US20070203337A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1610674A (zh) | 2005-04-27 |
CA2465695A1 (fr) | 2003-05-15 |
JP2005526005A (ja) | 2005-09-02 |
HUP0402037A2 (hu) | 2005-01-28 |
DE60209806D1 (de) | 2006-05-04 |
EP1446393B1 (fr) | 2006-03-08 |
WO2003040115A1 (fr) | 2003-05-15 |
US7227022B2 (en) | 2007-06-05 |
DK1446393T3 (da) | 2006-07-10 |
US20040157843A1 (en) | 2004-08-12 |
HRP20040400A2 (en) | 2004-10-31 |
ES2256583T3 (es) | 2006-07-16 |
US20030166646A1 (en) | 2003-09-04 |
MA27078A1 (fr) | 2004-12-20 |
RU2004117526A (ru) | 2005-04-10 |
PT1446393E (pt) | 2006-05-31 |
EP1446393A1 (fr) | 2004-08-18 |
US20050288501A1 (en) | 2005-12-29 |
NO20033129D0 (no) | 2003-07-08 |
IL161841A0 (en) | 2005-11-20 |
CA2669810A1 (fr) | 2003-05-15 |
IL161841A (en) | 2007-07-24 |
PL370324A1 (en) | 2005-05-16 |
CN1314674C (zh) | 2007-05-09 |
US6699867B2 (en) | 2004-03-02 |
DE60209806T2 (de) | 2006-11-02 |
US20070203337A1 (en) | 2007-08-30 |
MXPA04003695A (es) | 2004-07-30 |
US6953796B2 (en) | 2005-10-11 |
ATE319693T1 (de) | 2006-03-15 |
NO20033129L (no) | 2003-08-27 |
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