NO995403L - Amidinderivater som inhibitorer av nitrogenoksydsyntase - Google Patents

Amidinderivater som inhibitorer av nitrogenoksydsyntase

Info

Publication number
NO995403L
NO995403L NO995403A NO995403A NO995403L NO 995403 L NO995403 L NO 995403L NO 995403 A NO995403 A NO 995403A NO 995403 A NO995403 A NO 995403A NO 995403 L NO995403 L NO 995403L
Authority
NO
Norway
Prior art keywords
nitric oxide
oxide synthase
inhibitors
amidine derivatives
compounds
Prior art date
Application number
NO995403A
Other languages
English (en)
Other versions
NO995403D0 (no
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO995403D0 publication Critical patent/NO995403D0/no
Publication of NO995403L publication Critical patent/NO995403L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser av formel (I) HN hvor R1 representerer en 2-tienyl- eller 3-tienylring og R2 representerer hydrogen eller C l-4 alkyl og optiske isomerer og racemater derav og farmasøytisk akseptable salter derav; samt fremgangsmåter for deres fremstilling, preparater inneholdende forbindelsene og deres anvendelse i terapi. Forbindelsene er selektive inhibitorer av den neuronale isoformen av nitrogenoksydsyntase.
NO995403A 1997-05-05 1999-11-04 Amidinderivater som inhibitorer av nitrogenoksydsyntase NO995403L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701681A SE9701681D0 (sv) 1997-05-05 1997-05-05 New compounds
PCT/SE1998/000785 WO1998050382A1 (en) 1997-05-05 1998-04-28 Amidine derivatives as inhibitors of nitric oxide synthase

Publications (2)

Publication Number Publication Date
NO995403D0 NO995403D0 (no) 1999-11-04
NO995403L true NO995403L (no) 2000-01-05

Family

ID=20406835

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995403A NO995403L (no) 1997-05-05 1999-11-04 Amidinderivater som inhibitorer av nitrogenoksydsyntase

Country Status (25)

Country Link
US (1) US6489322B1 (no)
EP (1) EP0983268B1 (no)
JP (1) JP2001523262A (no)
KR (1) KR20010012228A (no)
CN (1) CN1255131A (no)
AR (1) AR012601A1 (no)
AT (1) ATE221065T1 (no)
AU (1) AU734391B2 (no)
BR (1) BR9809218A (no)
CA (1) CA2288333A1 (no)
DE (1) DE69806750T2 (no)
EE (1) EE9900474A (no)
HU (1) HUP0001873A3 (no)
ID (1) ID22885A (no)
IL (1) IL132678A0 (no)
IS (1) IS5236A (no)
MX (1) MXPA99009882A (no)
NO (1) NO995403L (no)
NZ (1) NZ500675A (no)
PL (1) PL336853A1 (no)
SE (1) SE9701681D0 (no)
SK (1) SK140599A3 (no)
TR (1) TR199902720T2 (no)
WO (1) WO1998050382A1 (no)
ZA (1) ZA983736B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
JPWO2006118104A1 (ja) * 2005-04-26 2008-12-18 株式会社東芝 白色ｌｅｄおよびそれを用いたバックライト並びに液晶表示装置
CN101258135A (zh) * 2005-07-05 2008-09-03 阿斯利康(瑞典)有限公司 新化合物、其制备方法、中间体、药物组合物和其在治疗5－ht6介导的疾病例如阿尔茨海默病、认知障碍、精神分裂症相关的认知缺损、肥胖和帕金森病中的用途
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
WO2008053446A2 (en) * 2006-11-02 2008-05-08 Piramal Life Sciences Limited Benzoxazepine compounds, their preparation and use
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
WO2008144483A2 (en) * 2007-05-18 2008-11-27 Armgo Pharma, Inc. Agents for treating disorders involving modulation of ryanodine receptors
WO2010135524A1 (en) * 2009-05-22 2010-11-25 Exelixis, Inc. Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009619A2 (en) 1993-10-04 1995-04-13 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
PL180081B1 (pl) 1993-08-12 2000-12-29 Astra Ab Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL
AU688811B2 (en) 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
CA2188680A1 (en) * 1994-05-07 1996-01-25 James Edwin Macdonald Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
TW397812B (en) 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
CZ287969B6 (cs) 1995-08-10 2001-03-14 Astra Pharmaceuticals Limited Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití
TW458978B (en) 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
NZ500675A (en) 2001-05-25
DE69806750D1 (de) 2002-08-29
IL132678A0 (en) 2001-03-19
DE69806750T2 (de) 2003-03-06
JP2001523262A (ja) 2001-11-20
SE9701681D0 (sv) 1997-05-05
CA2288333A1 (en) 1998-11-12
TR199902720T2 (xx) 2000-02-21
EP0983268B1 (en) 2002-07-24
AU7459898A (en) 1998-11-27
HUP0001873A3 (en) 2001-12-28
MXPA99009882A (es) 2005-11-22
AR012601A1 (es) 2000-11-08
ZA983736B (en) 1998-11-05
AU734391B2 (en) 2001-06-14
SK140599A3 (en) 2000-06-12
EE9900474A (et) 2000-06-15
EP0983268A1 (en) 2000-03-08
IS5236A (is) 1999-11-01
CN1255131A (zh) 2000-05-31
WO1998050382A1 (en) 1998-11-12
PL336853A1 (en) 2000-07-17
ID22885A (id) 1999-12-16
HUP0001873A2 (hu) 2001-01-29
US6489322B1 (en) 2002-12-03
NO995403D0 (no) 1999-11-04
ATE221065T1 (de) 2002-08-15
BR9809218A (pt) 2000-06-27
KR20010012228A (ko) 2001-02-15

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application