NO982072L - Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase - Google Patents

Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase

Info

Publication number
NO982072L
NO982072L NO982072A NO982072A NO982072L NO 982072 L NO982072 L NO 982072L NO 982072 A NO982072 A NO 982072A NO 982072 A NO982072 A NO 982072A NO 982072 L NO982072 L NO 982072L
Authority
NO
Norway
Prior art keywords
amidine
inhibitors
nitric oxide
oxide synthase
isothiourea derivatives
Prior art date
Application number
NO982072A
Other languages
English (en)
Other versions
NO982072D0 (no
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO982072D0 publication Critical patent/NO982072D0/no
Publication of NO982072L publication Critical patent/NO982072L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Treating Waste Gases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Gas Separation By Absorption (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Nye forbindelser av formel (I) hvor X, R , R , R , R4 og R5 er som definert heri, og optiske isomerer og racemater derav og farmasøytisk akseptable salter derav; samt fremgangsmåter for deres frem- stilling, preparater inneholdende disse forbindelsene og deres anvendelse i terapi.
NO982072A 1995-11-07 1998-05-06 Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase NO982072L (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US627695P 1995-11-07 1995-11-07
US625395P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (2)

Publication Number Publication Date
NO982072D0 NO982072D0 (no) 1998-05-06
NO982072L true NO982072L (no) 1998-07-03

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982072A NO982072L (no) 1995-11-07 1998-05-06 Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase

Country Status (24)

Country Link
EP (1) EP0861250B1 (no)
JP (1) JP2000500132A (no)
KR (1) KR19990067349A (no)
AT (1) ATE213241T1 (no)
AU (1) AU701329B2 (no)
BR (1) BR9611276A (no)
CA (1) CA2235301A1 (no)
CZ (1) CZ139298A3 (no)
DE (1) DE69619259T2 (no)
DK (1) DK0861250T3 (no)
EE (1) EE9800141A (no)
ES (1) ES2171743T3 (no)
HU (1) HUP9900142A3 (no)
IL (1) IL124296A0 (no)
IS (1) IS4725A (no)
NO (1) NO982072L (no)
NZ (1) NZ322227A (no)
PL (1) PL326554A1 (no)
PT (1) PT861250E (no)
SI (1) SI0861250T1 (no)
SK (1) SK61098A3 (no)
TR (1) TR199800813T2 (no)
TW (1) TW458978B (no)
WO (1) WO1997017344A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4947197A (en) * 1996-10-16 1998-05-11 Glaxo Group Limited Tetrahydro-6h-pyrazino{1,2-b}isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
IL162310A0 (en) 2001-12-19 2005-11-20 Lundbeck & Co As H 3,4-Dihydro-1h-isoquinoloin-2-yl-derivatives
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
AU2003257300B2 (en) * 2002-08-07 2010-01-21 Neuraxon Inc. Amino benzothiazole compounds with NOS inhibitory activity
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
JP2009501705A (ja) * 2005-07-05 2009-01-22 アストラゼネカ・アクチエボラーグ 新規化合物、その製造方法、中間体、医薬組成物、並びにアルツハイマー病、認知障害、統合失調症に伴う認識機能障害、肥満及びパーキンソン病のような５−ｈｔ６介在疾患の治療におけるそれらの使用
US8247403B2 (en) 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
ES2960374T3 (es) 2016-12-23 2024-03-04 Daiichi Sankyo Co Ltd Compuestos de sulfonamida con actividad inhibidora de la TNAP

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021621A1 (en) * 1993-03-23 1994-09-29 Astra Aktiebolag Guanidine derivatives useful in therapy
CZ29996A3 (en) * 1993-08-12 1996-09-11 Astra Ab Amidine derivatives with activities of nitrogen oxide sythetase
AU7705694A (en) * 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
EE9800141A (et) 1998-10-15
WO1997017344A1 (en) 1997-05-15
PT861250E (pt) 2002-07-31
ATE213241T1 (de) 2002-02-15
TW458978B (en) 2001-10-11
HUP9900142A3 (en) 2001-08-28
DE69619259D1 (de) 2002-03-21
NZ322227A (en) 1999-11-29
EP0861250A1 (en) 1998-09-02
AU701329B2 (en) 1999-01-28
DK0861250T3 (da) 2002-04-29
KR19990067349A (ko) 1999-08-16
NO982072D0 (no) 1998-05-06
IL124296A0 (en) 1998-12-06
JP2000500132A (ja) 2000-01-11
HUP9900142A2 (hu) 1999-05-28
SI0861250T1 (en) 2002-06-30
ES2171743T3 (es) 2002-09-16
SK61098A3 (en) 1999-01-11
CZ139298A3 (cs) 1998-09-16
AU7592796A (en) 1997-05-29
EP0861250B1 (en) 2002-02-13
BR9611276A (pt) 1999-01-26
CA2235301A1 (en) 1997-05-15
PL326554A1 (en) 1998-09-28
TR199800813T2 (xx) 1998-07-21
DE69619259T2 (de) 2002-09-19
MX9803453A (es) 1998-09-30
IS4725A (is) 1998-04-24

Similar Documents

Publication Publication Date Title
NO20075059L (no) Nye forbindelser II 2-pyridinderivater som inhibitorer av neutrofil elastase
NO971471L (no) Nye karboksamider med fungicid aktivitet
NO20000311L (no) Nye forbindelser
NO20045369L (no) Nye, substituerte sulfamatanticonvulsivaderivater
NO20025821L (no) 2-aminokarbonyl-9H-purinderivater
NO996108L (no) 9-oksinerytromycinderivater
WO2002090332A3 (en) Novel aeylheteroalkylaminε derivatives
NO20070570L (no) Forbindelser.
NO994900L (no) Forbindelser
NO934196L (no) N,N-disubstituerte arylcykloalkylaminer, deres salter, legemidler inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for deres fremstilling
NO984470L (no) Pyrrolopyrrolon-derivater som inhibitorer for neutrofil elastase
SE9803518D0 (sv) Novel compounds
NO982072L (no) Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase
NO20004089L (no) Nye triazolo(4,5-d)pyrimidinforbindelser
NO20023001L (no) Substituerte piperazinderivater som MTP inhibitorer
DK0634396T3 (da) Aminosyrederivater og deres anvendelse som enkeltfalinaseinhibitorer
NO20026081L (no) Nye forbindelser
NO995403L (no) Amidinderivater som inhibitorer av nitrogenoksydsyntase
NO995404L (no) Forbindelser
SE0202461D0 (sv) Novel compounds
NO20053805L (no) Diarylmetylindenpiperidinderivater, framgangsmate for fremstilling derav, og anvendelse derav
SE9904676D0 (sv) Novel compounds
SE9901901D0 (sv) Compounds
NO996544L (no) Forbindelser
NO20013601L (no) Nye morfolinobenzamidsalter

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application