DK0861250T3 - Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase - Google Patents

Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase

Info

Publication number
DK0861250T3
DK0861250T3 DK96938584T DK96938584T DK0861250T3 DK 0861250 T3 DK0861250 T3 DK 0861250T3 DK 96938584 T DK96938584 T DK 96938584T DK 96938584 T DK96938584 T DK 96938584T DK 0861250 T3 DK0861250 T3 DK 0861250T3
Authority
DK
Denmark
Prior art keywords
amindine
inhibitors
nitrogen monoxide
isothiourea derivatives
monoxide synthase
Prior art date
Application number
DK96938584T
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0861250T3 publication Critical patent/DK0861250T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Treating Waste Gases (AREA)
  • Gas Separation By Absorption (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK96938584T 1995-11-07 1996-11-06 Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase DK0861250T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US625395P 1995-11-07 1995-11-07
US627695P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
DK0861250T3 true DK0861250T3 (da) 2002-04-29

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96938584T DK0861250T3 (da) 1995-11-07 1996-11-06 Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase

Country Status (24)

Country Link
EP (1) EP0861250B1 (da)
JP (1) JP2000500132A (da)
KR (1) KR19990067349A (da)
AT (1) ATE213241T1 (da)
AU (1) AU701329B2 (da)
BR (1) BR9611276A (da)
CA (1) CA2235301A1 (da)
CZ (1) CZ139298A3 (da)
DE (1) DE69619259T2 (da)
DK (1) DK0861250T3 (da)
EE (1) EE9800141A (da)
ES (1) ES2171743T3 (da)
HU (1) HUP9900142A3 (da)
IL (1) IL124296A0 (da)
IS (1) IS4725A (da)
NO (1) NO982072L (da)
NZ (1) NZ322227A (da)
PL (1) PL326554A1 (da)
PT (1) PT861250E (da)
SI (1) SI0861250T1 (da)
SK (1) SK61098A3 (da)
TR (1) TR199800813T2 (da)
TW (1) TW458978B (da)
WO (1) WO1997017344A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016526A1 (en) * 1996-10-16 1998-04-23 Glaxo Group Limited Tetrahydro-6h-pyrazino[1,2-b]isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
IL162310A0 (en) 2001-12-19 2005-11-20 Lundbeck & Co As H 3,4-Dihydro-1h-isoquinoloin-2-yl-derivatives
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
EP1539724B1 (en) * 2002-08-07 2007-10-10 Neuraxon Inc. Amino benzothiazole compounds with nos inhibitory activity
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
CN101258135A (zh) * 2005-07-05 2008-09-03 阿斯利康(瑞典)有限公司 新化合物、其制备方法、中间体、药物组合物和其在治疗5－ht6介导的疾病例如阿尔茨海默病、认知障碍、精神分裂症相关的认知缺损、肥胖和帕金森病中的用途
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
WO2018119444A1 (en) 2016-12-23 2018-06-28 Daiichi Sankyo Company, Limited Sulfonamide compounds having tnap inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009619A2 (en) * 1993-10-04 1995-04-13 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
US5885985A (en) * 1993-03-23 1999-03-23 Astra Aktiebolag Guanidine derivatives useful in therapy
PL180081B1 (pl) * 1993-08-12 2000-12-29 Astra Ab Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
AU7592796A (en) 1997-05-29
PL326554A1 (en) 1998-09-28
ES2171743T3 (es) 2002-09-16
IS4725A (is) 1998-04-24
HUP9900142A2 (hu) 1999-05-28
EP0861250B1 (en) 2002-02-13
NO982072D0 (no) 1998-05-06
JP2000500132A (ja) 2000-01-11
DE69619259D1 (de) 2002-03-21
TR199800813T2 (xx) 1998-07-21
HUP9900142A3 (en) 2001-08-28
ATE213241T1 (de) 2002-02-15
IL124296A0 (en) 1998-12-06
DE69619259T2 (de) 2002-09-19
SI0861250T1 (en) 2002-06-30
AU701329B2 (en) 1999-01-28
CA2235301A1 (en) 1997-05-15
EP0861250A1 (en) 1998-09-02
TW458978B (en) 2001-10-11
BR9611276A (pt) 1999-01-26
EE9800141A (et) 1998-10-15
MX9803453A (es) 1998-09-30
WO1997017344A1 (en) 1997-05-15
SK61098A3 (en) 1999-01-11
CZ139298A3 (cs) 1998-09-16
KR19990067349A (ko) 1999-08-16
NZ322227A (en) 1999-11-29
PT861250E (pt) 2002-07-31
NO982072L (no) 1998-07-03

Similar Documents

Publication Publication Date Title
DK0562956T3 (da) Hidtil ukendte naphthylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
IL126610A0 (en) N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3- one derivatives as factor xa inhibitors
NO20025821L (no) 2-aminokarbonyl-9H-purinderivater
SE0202463D0 (sv) Novel compounds
SE0302487D0 (sv) Novel compounds
HK1089163A1 (en) Quinoxaline derivatives as neutrophil elastase inhibitors and their use
DK0530087T3 (da) Hidtil ukendte naphthylethylurinstof- og naphthylethylthiourinstofforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
NO996108L (no) 9-oksinerytromycinderivater
SE0302323D0 (sv) Novel compounds
DK0861250T3 (da) Amindin- og isothiourinstofderivater som inhibitorer for nitrogenmonoxidsyntase
DK0634396T3 (da) Aminosyrederivater og deres anvendelse som enkeltfalinaseinhibitorer
FI964045A0 (fi) CCK:ta tai gastriinia säätelevä 5-heterosykli-1,5-bentsodiatsepiinejä
DK0490816T3 (da) Fluorforbindelser som aromatase-inhibitorer.
HK1023346A1 (en) Novel substituted tetrahyropyridine derivatives, method of preparation and pharmaceutical compositions containing them
DE69330601D1 (de) Serotoninergische ergolin derivate
SE0202461D0 (sv) Novel compounds
DK0533516T3 (da) Hidtil ukendte 1-(alkoxybenzyl)piperazinamidforbindelser, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem
MXPA99009882A (es) Derivados de amidina como inhibidores de la oxidonitrico sintasa.
SE9901901D0 (sv) Compounds
SE9904676D0 (sv) Novel compounds
NO973341L (no) Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for vasodilatorisk behandling eller profylakse
NO973242L (no) Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for behandling eller profylakse av idiopatisk eller fysiologisk gynekomasti
SE9800835D0 (sv) New Compounds
SE9904677D0 (sv) Novel compounds
WO2001058867A3 (en) Novel compounds