MX9803453A - Derivados de amidina e isotiourea como inhibidores de oxido nitrico sintasa. - Google Patents
Derivados de amidina e isotiourea como inhibidores de oxido nitrico sintasa.Info
- Publication number
- MX9803453A MX9803453A MX9803453A MX9803453A MX9803453A MX 9803453 A MX9803453 A MX 9803453A MX 9803453 A MX9803453 A MX 9803453A MX 9803453 A MX9803453 A MX 9803453A MX 9803453 A MX9803453 A MX 9803453A
- Authority
- MX
- Mexico
- Prior art keywords
- amidine
- inhibitors
- nitric oxide
- oxide synthase
- isothiourea derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Exhaust Gas Treatment By Means Of Catalyst (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Treating Waste Gases (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Gas Separation By Absorption (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se proporcionan compuestos novedosos de formula (I), en la que X, R1, R2, R3, R4 y R5 son como se definen en la especificacion, e isomeros opticos y racematos de los mismos, y sales farmacéuticamente aceptables de los mismos, junto con procesos para su preparacion, composiciones que los contienen y su uso en terapia.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US006276 | 1993-01-15 | ||
| US627695P | 1995-11-07 | 1995-11-07 | |
| US625395P | 1995-11-07 | 1995-11-07 | |
| US006253 | 1995-11-07 | ||
| SE9600275A SE9600275D0 (sv) | 1996-01-25 | 1996-01-25 | Compounds |
| SE9600275-3 | 1996-01-25 | ||
| SE9603300-6 | 1996-09-11 | ||
| SE9603300A SE9603300D0 (sv) | 1996-09-11 | 1996-09-11 | Compounds |
| SE9603301A SE9603301D0 (sv) | 1996-09-11 | 1996-09-11 | Compounds and compositions |
| SE9603301-4 | 1996-09-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9803453A true MX9803453A (es) | 1998-09-30 |
| MXPA98003453A MXPA98003453A (es) | 1998-11-16 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| EE9800141A (et) | 1998-10-15 |
| WO1997017344A1 (en) | 1997-05-15 |
| PT861250E (pt) | 2002-07-31 |
| ATE213241T1 (de) | 2002-02-15 |
| TW458978B (en) | 2001-10-11 |
| HUP9900142A3 (en) | 2001-08-28 |
| DE69619259D1 (de) | 2002-03-21 |
| NZ322227A (en) | 1999-11-29 |
| EP0861250A1 (en) | 1998-09-02 |
| AU701329B2 (en) | 1999-01-28 |
| DK0861250T3 (da) | 2002-04-29 |
| KR19990067349A (ko) | 1999-08-16 |
| NO982072D0 (no) | 1998-05-06 |
| IL124296A0 (en) | 1998-12-06 |
| JP2000500132A (ja) | 2000-01-11 |
| HUP9900142A2 (hu) | 1999-05-28 |
| SI0861250T1 (en) | 2002-06-30 |
| ES2171743T3 (es) | 2002-09-16 |
| SK61098A3 (en) | 1999-01-11 |
| CZ139298A3 (cs) | 1998-09-16 |
| AU7592796A (en) | 1997-05-29 |
| EP0861250B1 (en) | 2002-02-13 |
| BR9611276A (pt) | 1999-01-26 |
| CA2235301A1 (en) | 1997-05-15 |
| PL326554A1 (en) | 1998-09-28 |
| TR199800813T2 (xx) | 1998-07-21 |
| NO982072L (no) | 1998-07-03 |
| DE69619259T2 (de) | 2002-09-19 |
| IS4725A (is) | 1998-04-24 |
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