NO995404L - Forbindelser - Google Patents

Forbindelser

Info

Publication number
NO995404L
NO995404L NO995404A NO995404A NO995404L NO 995404 L NO995404 L NO 995404L NO 995404 A NO995404 A NO 995404A NO 995404 A NO995404 A NO 995404A NO 995404 L NO995404 L NO 995404L
Authority
NO
Norway
Prior art keywords
compounds
thienyl
racemates
therapy
alkyl
Prior art date
Application number
NO995404A
Other languages
English (en)
Other versions
NO995404D0 (no
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO995404D0 publication Critical patent/NO995404D0/no
Publication of NO995404L publication Critical patent/NO995404L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser av formel (I): HN d) hvor R1 representerer en 2-tienyl- eller 3-tienylring og R2 representerer C l-4 alkyl, og optiske isomerer og racemater derav og farmasøytisk akseptable salter derav, samt fremgangsmåter for deres fremstilling, preparater som inneholder forbindelsene og deres anvendelse i terapi. Forbindelsene er selektive inhibitorer av den neuronale isoformen av nitrogenoksydsyntase.
NO995404A 1997-05-05 1999-11-04 Forbindelser NO995404L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701682A SE9701682D0 (sv) 1997-05-05 1997-05-05 Compounds
PCT/SE1998/000792 WO1998050380A1 (en) 1997-05-05 1998-04-28 Compounds

Publications (2)

Publication Number Publication Date
NO995404D0 NO995404D0 (no) 1999-11-04
NO995404L true NO995404L (no) 2000-01-05

Family

ID=20406836

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995404A NO995404L (no) 1997-05-05 1999-11-04 Forbindelser

Country Status (28)

Country Link
US (1) US6166030A (no)
EP (1) EP0983266B1 (no)
JP (1) JP2001523263A (no)
KR (1) KR20010012227A (no)
CN (1) CN1255130A (no)
AR (1) AR012602A1 (no)
AT (1) ATE210661T1 (no)
AU (1) AU734394B2 (no)
BR (1) BR9808725A (no)
CA (1) CA2287999A1 (no)
DE (1) DE69802923T2 (no)
DK (1) DK0983266T3 (no)
EE (1) EE9900475A (no)
ES (1) ES2168757T3 (no)
HU (1) HUP0003766A3 (no)
ID (1) ID23156A (no)
IL (1) IL132677A0 (no)
IS (1) IS5237A (no)
MX (1) MXPA99009874A (no)
NO (1) NO995404L (no)
NZ (1) NZ500676A (no)
PL (1) PL336854A1 (no)
PT (1) PT983266E (no)
SE (1) SE9701682D0 (no)
SK (1) SK140699A3 (no)
TR (1) TR199902719T2 (no)
WO (1) WO1998050380A1 (no)
ZA (1) ZA983740B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024826A2 (en) * 1999-10-06 2001-04-12 The Brigham And Women's Hospital, Inc. Inrease of enos activity through activation of the pi3-kinase/akt pathway by estrogens
US7115653B2 (en) * 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) * 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) * 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US7375219B2 (en) 2005-04-13 2008-05-20 Neuraxon, Inc. Substituted indole compounds having NOS inhibitory activity
US8173813B2 (en) * 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
EA201000808A1 (ru) 2007-11-16 2011-04-29 Ньюраксон, Инк. Индольные соединения и способы лечения висцеральной боли

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE231126T1 (de) * 1993-08-12 2003-02-15 Astrazeneca Ab Amidin-derivate mit stickstoffoxid-synthease- aktivität
AU7705694A (en) * 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
CN1077886C (zh) * 1993-10-21 2002-01-16 G·D·瑟尔公司 用作一氧化一氮合酶抑制剂的脒基衍生物
CA2188680A1 (en) * 1994-05-07 1996-01-25 James Edwin Macdonald Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
BR9509297A (pt) * 1995-08-10 1998-07-07 Astra Ab Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto

Also Published As

Publication number Publication date
AU7460098A (en) 1998-11-27
AU734394B2 (en) 2001-06-14
US6166030A (en) 2000-12-26
ES2168757T3 (es) 2002-06-16
EE9900475A (et) 2000-06-15
SK140699A3 (en) 2000-06-12
ZA983740B (en) 1999-02-19
MXPA99009874A (es) 2004-09-30
DE69802923D1 (de) 2002-01-24
NO995404D0 (no) 1999-11-04
DK0983266T3 (da) 2002-03-11
KR20010012227A (ko) 2001-02-15
JP2001523263A (ja) 2001-11-20
EP0983266A1 (en) 2000-03-08
HUP0003766A3 (en) 2001-09-28
PL336854A1 (en) 2000-07-17
DE69802923T2 (de) 2002-07-04
IS5237A (is) 1999-11-01
AR012602A1 (es) 2000-11-08
BR9808725A (pt) 2000-07-11
IL132677A0 (en) 2001-03-19
WO1998050380A1 (en) 1998-11-12
HUP0003766A2 (en) 2001-03-28
PT983266E (pt) 2002-05-31
CN1255130A (zh) 2000-05-31
EP0983266B1 (en) 2001-12-12
SE9701682D0 (sv) 1997-05-05
NZ500676A (en) 2001-05-25
ID23156A (id) 2000-03-23
TR199902719T2 (xx) 2000-02-21
ATE210661T1 (de) 2001-12-15
CA2287999A1 (en) 1998-11-12

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application