ATE221065T1 - Amidinderivate als inhibitoren von no-synthase - Google Patents

Amidinderivate als inhibitoren von no-synthase

Info

Publication number
ATE221065T1
ATE221065T1 AT98921951T AT98921951T ATE221065T1 AT E221065 T1 ATE221065 T1 AT E221065T1 AT 98921951 T AT98921951 T AT 98921951T AT 98921951 T AT98921951 T AT 98921951T AT E221065 T1 ATE221065 T1 AT E221065T1
Authority
AT
Austria
Prior art keywords
amidene
derivatives
synthase inhibitors
synthase
inhibitors
Prior art date
Application number
AT98921951T
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE221065T1 publication Critical patent/ATE221065T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98921951T 1997-05-05 1998-04-28 Amidinderivate als inhibitoren von no-synthase ATE221065T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701681A SE9701681D0 (sv) 1997-05-05 1997-05-05 New compounds
PCT/SE1998/000785 WO1998050382A1 (en) 1997-05-05 1998-04-28 Amidine derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
ATE221065T1 true ATE221065T1 (de) 2002-08-15

Family

ID=20406835

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98921951T ATE221065T1 (de) 1997-05-05 1998-04-28 Amidinderivate als inhibitoren von no-synthase

Country Status (25)

Country Link
US (1) US6489322B1 (de)
EP (1) EP0983268B1 (de)
JP (1) JP2001523262A (de)
KR (1) KR20010012228A (de)
CN (1) CN1255131A (de)
AR (1) AR012601A1 (de)
AT (1) ATE221065T1 (de)
AU (1) AU734391B2 (de)
BR (1) BR9809218A (de)
CA (1) CA2288333A1 (de)
DE (1) DE69806750T2 (de)
EE (1) EE9900474A (de)
HU (1) HUP0001873A3 (de)
ID (1) ID22885A (de)
IL (1) IL132678A0 (de)
IS (1) IS5236A (de)
MX (1) MXPA99009882A (de)
NO (1) NO995403L (de)
NZ (1) NZ500675A (de)
PL (1) PL336853A1 (de)
SE (1) SE9701681D0 (de)
SK (1) SK140599A3 (de)
TR (1) TR199902720T2 (de)
WO (1) WO1998050382A1 (de)
ZA (1) ZA983736B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
WO2006118104A1 (ja) * 2005-04-26 2006-11-09 Kabushiki Kaisha Toshiba 白色ｌｅｄおよびそれを用いたバックライト並びに液晶表示装置
EP1910321A4 (de) * 2005-07-05 2010-09-01 Astrazeneca Ab Neue verbindungen, verfahren zu ihrer herstellung, zwischenprodukte, pharmazeutische zusammensetzungen und ihre verwendung bei der behandlung von durch 5-ht6-vermittelten erkrankungen wie alzheimer-krankheit, kognitiven erkrankungen, mit schizophrenie assoziierten kognitiven störungen, obesitas und parkinson-krankheit
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
WO2008053446A2 (en) * 2006-11-02 2008-05-08 Piramal Life Sciences Limited Benzoxazepine compounds, their preparation and use
EP2123644B1 (de) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Benzoxazepin-derivate und deren anwendung
WO2008144483A2 (en) * 2007-05-18 2008-11-27 Armgo Pharma, Inc. Agents for treating disorders involving modulation of ryanodine receptors
WO2010135524A1 (en) * 2009-05-22 2010-11-25 Exelixis, Inc. Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK16396A3 (en) 1993-08-12 1996-09-04 Astra Ab Amidine derivatives with nitric oxide synthetase activities
EP0723438A1 (de) 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substitutierte harnstoff und isothioharnstoff derivate als no synthase inhibitoren
AU688811B2 (en) 1993-10-21 1998-03-19 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
US5807886A (en) * 1994-05-07 1998-09-15 Astra Aktiebolag Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
CZ287969B6 (cs) 1995-08-10 2001-03-14 Astra Pharmaceuticals Limited Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití
TW458978B (en) 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
NO995403L (no) 2000-01-05
AU734391B2 (en) 2001-06-14
ZA983736B (en) 1998-11-05
SK140599A3 (en) 2000-06-12
EE9900474A (et) 2000-06-15
KR20010012228A (ko) 2001-02-15
IS5236A (is) 1999-11-01
NO995403D0 (no) 1999-11-04
CN1255131A (zh) 2000-05-31
WO1998050382A1 (en) 1998-11-12
AU7459898A (en) 1998-11-27
PL336853A1 (en) 2000-07-17
BR9809218A (pt) 2000-06-27
DE69806750T2 (de) 2003-03-06
DE69806750D1 (de) 2002-08-29
IL132678A0 (en) 2001-03-19
ID22885A (id) 1999-12-16
SE9701681D0 (sv) 1997-05-05
MXPA99009882A (es) 2005-11-22
NZ500675A (en) 2001-05-25
TR199902720T2 (xx) 2000-02-21
HUP0001873A3 (en) 2001-12-28
US6489322B1 (en) 2002-12-03
EP0983268B1 (de) 2002-07-24
JP2001523262A (ja) 2001-11-20
CA2288333A1 (en) 1998-11-12
EP0983268A1 (de) 2000-03-08
HUP0001873A2 (hu) 2001-01-29
AR012601A1 (es) 2000-11-08

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties