DE69806750T2 - Amidinderivate als inhibitoren von no-synthase - Google Patents

Amidinderivate als inhibitoren von no-synthase

Info

Publication number
DE69806750T2
DE69806750T2 DE69806750T DE69806750T DE69806750T2 DE 69806750 T2 DE69806750 T2 DE 69806750T2 DE 69806750 T DE69806750 T DE 69806750T DE 69806750 T DE69806750 T DE 69806750T DE 69806750 T2 DE69806750 T2 DE 69806750T2
Authority
DE
Germany
Prior art keywords
synthase
inhibitors
amidine derivatives
amidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806750T
Other languages
English (en)
Other versions
DE69806750D1 (de
Inventor
James Macdonald
James Matz
William Shakespeare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69806750D1 publication Critical patent/DE69806750D1/de
Publication of DE69806750T2 publication Critical patent/DE69806750T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69806750T 1997-05-05 1998-04-28 Amidinderivate als inhibitoren von no-synthase Expired - Fee Related DE69806750T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701681A SE9701681D0 (sv) 1997-05-05 1997-05-05 New compounds
PCT/SE1998/000785 WO1998050382A1 (en) 1997-05-05 1998-04-28 Amidine derivatives as inhibitors of nitric oxide synthase

Publications (2)

Publication Number Publication Date
DE69806750D1 DE69806750D1 (de) 2002-08-29
DE69806750T2 true DE69806750T2 (de) 2003-03-06

Family

ID=20406835

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806750T Expired - Fee Related DE69806750T2 (de) 1997-05-05 1998-04-28 Amidinderivate als inhibitoren von no-synthase

Country Status (25)

Country Link
US (1) US6489322B1 (de)
EP (1) EP0983268B1 (de)
JP (1) JP2001523262A (de)
KR (1) KR20010012228A (de)
CN (1) CN1255131A (de)
AR (1) AR012601A1 (de)
AT (1) ATE221065T1 (de)
AU (1) AU734391B2 (de)
BR (1) BR9809218A (de)
CA (1) CA2288333A1 (de)
DE (1) DE69806750T2 (de)
EE (1) EE9900474A (de)
HU (1) HUP0001873A3 (de)
ID (1) ID22885A (de)
IL (1) IL132678A0 (de)
IS (1) IS5236A (de)
MX (1) MXPA99009882A (de)
NO (1) NO995403L (de)
NZ (1) NZ500675A (de)
PL (1) PL336853A1 (de)
SE (1) SE9701681D0 (de)
SK (1) SK140599A3 (de)
TR (1) TR199902720T2 (de)
WO (1) WO1998050382A1 (de)
ZA (1) ZA983736B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
CN101228641B (zh) * 2005-04-26 2013-01-02 株式会社东芝 白色led和利用该白色led的背光源以及液晶显示装置
JP2009501705A (ja) * 2005-07-05 2009-01-22 アストラゼネカ・アクチエボラーグ 新規化合物、その製造方法、中間体、医薬組成物、並びにアルツハイマー病、認知障害、統合失調症に伴う認識機能障害、肥満及びパーキンソン病のような５−ｈｔ６介在疾患の治療におけるそれらの使用
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
EP2077846B1 (de) * 2006-11-02 2011-10-12 Piramal Life Sciences Limited Benzoxazepin-verbindungen, ihre herstellung und verwendung
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
WO2008144483A2 (en) * 2007-05-18 2008-11-27 Armgo Pharma, Inc. Agents for treating disorders involving modulation of ryanodine receptors
JP2012527474A (ja) * 2009-05-22 2012-11-08 エクセリクシス， インク． 増殖性疾患に対するベンゾキサゼピンベースのｐｉ３ｋ／ｍｔ０ｒ阻害剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
CA2169280A1 (en) 1993-08-12 1995-02-23 Robert James Gentile Amidine derivatives with nitric oxide synthetase activities
EP0724570B1 (de) 1993-10-21 1999-03-03 G.D. Searle & Co. Amidino-derivate als no-synthetase inhibitoren
CA2188680A1 (en) * 1994-05-07 1996-01-25 James Edwin Macdonald Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
KR970706272A (ko) * 1995-08-10 1997-11-03 클래스 빌헬름슨 치료에 유용한 바이시클릭 아미딘 유도체(Bicyclic Amidine Derivatives Useful in Therapy)
TW458978B (en) * 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
CN1255131A (zh) 2000-05-31
MXPA99009882A (es) 2005-11-22
NO995403D0 (no) 1999-11-04
EP0983268A1 (de) 2000-03-08
JP2001523262A (ja) 2001-11-20
EE9900474A (et) 2000-06-15
BR9809218A (pt) 2000-06-27
ID22885A (id) 1999-12-16
TR199902720T2 (xx) 2000-02-21
KR20010012228A (ko) 2001-02-15
ZA983736B (en) 1998-11-05
ATE221065T1 (de) 2002-08-15
NO995403L (no) 2000-01-05
EP0983268B1 (de) 2002-07-24
HUP0001873A2 (hu) 2001-01-29
IS5236A (is) 1999-11-01
AU7459898A (en) 1998-11-27
CA2288333A1 (en) 1998-11-12
AU734391B2 (en) 2001-06-14
PL336853A1 (en) 2000-07-17
US6489322B1 (en) 2002-12-03
SK140599A3 (en) 2000-06-12
HUP0001873A3 (en) 2001-12-28
DE69806750D1 (de) 2002-08-29
IL132678A0 (en) 2001-03-19
NZ500675A (en) 2001-05-25
AR012601A1 (es) 2000-11-08
WO1998050382A1 (en) 1998-11-12
SE9701681D0 (sv) 1997-05-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee