EE200000137A - Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena - Google Patents
Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritenaInfo
- Publication number
- EE200000137A EE200000137A EEP200000137A EEP200000137A EE200000137A EE 200000137 A EE200000137 A EE 200000137A EE P200000137 A EEP200000137 A EE P200000137A EE P200000137 A EEP200000137 A EE P200000137A EE 200000137 A EE200000137 A EE 200000137A
- Authority
- EE
- Estonia
- Prior art keywords
- inhibitors
- neutrophil elastase
- pyrrolopyrrolone
- derivatives
- pyrrolopyrrolone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9719187.8A GB9719187D0 (en) | 1997-09-09 | 1997-09-09 | Compounds |
| PCT/EP1998/005604 WO1999012931A1 (en) | 1997-09-09 | 1998-09-07 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200000137A true EE200000137A (et) | 2001-02-15 |
Family
ID=10818820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000137A EE200000137A (et) | 1997-09-09 | 1998-09-07 | Pürrolopürrolooni derivaadid neutrofiili elastaasi inhibiitoritena |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6228853B1 (et) |
| EP (1) | EP1019406A1 (et) |
| JP (1) | JP2001515902A (et) |
| KR (1) | KR20010023830A (et) |
| CN (1) | CN1278821A (et) |
| AP (1) | AP2000001760A0 (et) |
| AU (1) | AU9536098A (et) |
| BR (1) | BR9811651A (et) |
| CA (1) | CA2303249A1 (et) |
| EA (1) | EA200000205A1 (et) |
| EE (1) | EE200000137A (et) |
| GB (1) | GB9719187D0 (et) |
| HR (1) | HRP20000136A2 (et) |
| HU (1) | HUP0003475A3 (et) |
| ID (1) | ID24364A (et) |
| IL (1) | IL134935A0 (et) |
| IS (1) | IS5394A (et) |
| MA (1) | MA26544A1 (et) |
| NO (1) | NO20001200L (et) |
| PL (1) | PL339186A1 (et) |
| SK (1) | SK3242000A3 (et) |
| TR (1) | TR200001026T2 (et) |
| WO (1) | WO1999012931A1 (et) |
| ZA (1) | ZA988162B (et) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| US9034653B2 (en) | 2009-12-11 | 2015-05-19 | Quest Diagnostics Investments Inc. | Mass spectrometry of steroidal compounds in multiplexed patient samples |
| US20120025067A1 (en) | 2009-12-11 | 2012-02-02 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
| KR20220079527A (ko) | 2019-09-17 | 2022-06-13 | 메레오 바이오파마 4 리미티드 | 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트 |
| AU2021256835A1 (en) | 2020-04-16 | 2022-10-13 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
| CA3234399A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983245A (en) | 1975-02-06 | 1976-09-28 | Smithkline Corporation | Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes |
| GB8512230D0 (en) | 1985-05-14 | 1985-06-19 | Shell Internationale Researche | Preparation of carboxylic acid salt |
| GB9211783D0 (en) | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
| GB9402680D0 (en) | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
| AU715229B2 (en) * | 1996-01-03 | 2000-01-20 | Smithkline Beecham Plc | Carbamoyloxy derivatives of mutiline and their use as antibacterials |
| EP0891362B1 (en) * | 1996-03-28 | 2004-03-17 | Glaxo Group Limited | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
-
1997
- 1997-09-09 GB GBGB9719187.8A patent/GB9719187D0/en not_active Ceased
-
1998
- 1998-09-07 TR TR2000/01026T patent/TR200001026T2/xx unknown
- 1998-09-07 AP APAP/P/2000/001760A patent/AP2000001760A0/en unknown
- 1998-09-07 KR KR1020007002505A patent/KR20010023830A/ko not_active Application Discontinuation
- 1998-09-07 SK SK324-2000A patent/SK3242000A3/sk unknown
- 1998-09-07 JP JP2000510738A patent/JP2001515902A/ja active Pending
- 1998-09-07 ID IDW20000665A patent/ID24364A/id unknown
- 1998-09-07 ZA ZA9808162A patent/ZA988162B/xx unknown
- 1998-09-07 EA EA200000205A patent/EA200000205A1/ru unknown
- 1998-09-07 WO PCT/EP1998/005604 patent/WO1999012931A1/en not_active Application Discontinuation
- 1998-09-07 AU AU95360/98A patent/AU9536098A/en not_active Abandoned
- 1998-09-07 US US09/508,326 patent/US6228853B1/en not_active Expired - Fee Related
- 1998-09-07 EE EEP200000137A patent/EE200000137A/et unknown
- 1998-09-07 CA CA002303249A patent/CA2303249A1/en not_active Abandoned
- 1998-09-07 EP EP98948905A patent/EP1019406A1/en not_active Withdrawn
- 1998-09-07 BR BR9811651-7A patent/BR9811651A/pt not_active Application Discontinuation
- 1998-09-07 CN CN98810967A patent/CN1278821A/zh active Pending
- 1998-09-07 IL IL13493598A patent/IL134935A0/xx unknown
- 1998-09-07 PL PL98339186A patent/PL339186A1/xx not_active Application Discontinuation
- 1998-09-07 HU HU0003475A patent/HUP0003475A3/hu unknown
- 1998-09-07 MA MA25244A patent/MA26544A1/fr unknown
-
2000
- 2000-03-03 IS IS5394A patent/IS5394A/is unknown
- 2000-03-08 NO NO20001200A patent/NO20001200L/no not_active Application Discontinuation
- 2000-03-09 HR HR20000136A patent/HRP20000136A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200000205A1 (ru) | 2000-10-30 |
| SK3242000A3 (en) | 2001-03-12 |
| ID24364A (id) | 2000-07-13 |
| MA26544A1 (fr) | 2004-12-20 |
| ZA988162B (en) | 2000-03-22 |
| HUP0003475A3 (en) | 2002-01-28 |
| NO20001200D0 (no) | 2000-03-08 |
| BR9811651A (pt) | 2000-08-08 |
| TR200001026T2 (tr) | 2000-09-21 |
| AP2000001760A0 (en) | 2000-03-31 |
| KR20010023830A (ko) | 2001-03-26 |
| CA2303249A1 (en) | 1999-03-18 |
| WO1999012931A1 (en) | 1999-03-18 |
| PL339186A1 (en) | 2000-12-04 |
| CN1278821A (zh) | 2001-01-03 |
| IS5394A (is) | 2000-03-03 |
| GB9719187D0 (en) | 1997-11-12 |
| US6228853B1 (en) | 2001-05-08 |
| IL134935A0 (en) | 2001-05-20 |
| HUP0003475A2 (hu) | 2001-09-28 |
| EP1019406A1 (en) | 2000-07-19 |
| AU9536098A (en) | 1999-03-29 |
| NO20001200L (no) | 2000-05-08 |
| HRP20000136A2 (en) | 2000-08-31 |
| JP2001515902A (ja) | 2001-09-25 |
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