MA26544A1 - Derives de pyrrolopyrrolone comme inhibiteurs d'elastase de neutrophiles - Google Patents
Derives de pyrrolopyrrolone comme inhibiteurs d'elastase de neutrophilesInfo
- Publication number
- MA26544A1 MA26544A1 MA25244A MA25244A MA26544A1 MA 26544 A1 MA26544 A1 MA 26544A1 MA 25244 A MA25244 A MA 25244A MA 25244 A MA25244 A MA 25244A MA 26544 A1 MA26544 A1 MA 26544A1
- Authority
- MA
- Morocco
- Prior art keywords
- elastase inhibitors
- neutrophilic elastase
- pyrrolopyrrolone
- derivatives
- pyrrolopyrrolone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9719187.8A GB9719187D0 (en) | 1997-09-09 | 1997-09-09 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26544A1 true MA26544A1 (fr) | 2004-12-20 |
Family
ID=10818820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA25244A MA26544A1 (fr) | 1997-09-09 | 1998-09-07 | Derives de pyrrolopyrrolone comme inhibiteurs d'elastase de neutrophiles |
Country Status (24)
Country | Link |
---|---|
US (1) | US6228853B1 (fr) |
EP (1) | EP1019406A1 (fr) |
JP (1) | JP2001515902A (fr) |
KR (1) | KR20010023830A (fr) |
CN (1) | CN1278821A (fr) |
AP (1) | AP2000001760A0 (fr) |
AU (1) | AU9536098A (fr) |
BR (1) | BR9811651A (fr) |
CA (1) | CA2303249A1 (fr) |
EA (1) | EA200000205A1 (fr) |
EE (1) | EE200000137A (fr) |
GB (1) | GB9719187D0 (fr) |
HR (1) | HRP20000136A2 (fr) |
HU (1) | HUP0003475A3 (fr) |
ID (1) | ID24364A (fr) |
IL (1) | IL134935A0 (fr) |
IS (1) | IS5394A (fr) |
MA (1) | MA26544A1 (fr) |
NO (1) | NO20001200L (fr) |
PL (1) | PL339186A1 (fr) |
SK (1) | SK3242000A3 (fr) |
TR (1) | TR200001026T2 (fr) |
WO (1) | WO1999012931A1 (fr) |
ZA (1) | ZA988162B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
JP5739903B2 (ja) | 2009-12-11 | 2015-06-24 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 複合試料中のステロイド化合物の質量分析 |
US20110240840A1 (en) | 2009-12-11 | 2011-10-06 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d |
EP4031138A1 (fr) | 2019-09-17 | 2022-07-27 | Mereo Biopharma 4 Limited | Alvélestat destiné à être utilisé dans le traitement du rejet de greffe, du syndrome de bronchiolite oblitérante et de la maladie du greffon contre l'hôte |
MX2022012942A (es) | 2020-04-16 | 2023-01-11 | Mereo Biopharma 4 Ltd | Metodos que involucran el inhibidor de la elastasa de neutrofilo alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina. |
IL312002A (en) | 2021-10-20 | 2024-06-01 | Mereo Biopharma 4 Ltd | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3983245A (en) * | 1975-02-06 | 1976-09-28 | Smithkline Corporation | Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes |
GB8512230D0 (en) | 1985-05-14 | 1985-06-19 | Shell Internationale Researche | Preparation of carboxylic acid salt |
GB9211783D0 (en) | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
GB9402680D0 (en) | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
PL327737A1 (en) * | 1996-01-03 | 1998-12-21 | Smithkline Beecham Plc | Carbamoyloxylic derivatives of mutiline and their application as bactericides |
EP0891362B1 (fr) * | 1996-03-28 | 2004-03-17 | Glaxo Group Limited | Derives du pyrrolopyrrolone utilises comme inhibiteurs de l'elastase de neutrophiles |
-
1997
- 1997-09-09 GB GBGB9719187.8A patent/GB9719187D0/en not_active Ceased
-
1998
- 1998-09-07 CA CA002303249A patent/CA2303249A1/fr not_active Abandoned
- 1998-09-07 WO PCT/EP1998/005604 patent/WO1999012931A1/fr not_active Application Discontinuation
- 1998-09-07 JP JP2000510738A patent/JP2001515902A/ja active Pending
- 1998-09-07 BR BR9811651-7A patent/BR9811651A/pt not_active Application Discontinuation
- 1998-09-07 ID IDW20000665A patent/ID24364A/id unknown
- 1998-09-07 PL PL98339186A patent/PL339186A1/xx not_active Application Discontinuation
- 1998-09-07 ZA ZA9808162A patent/ZA988162B/xx unknown
- 1998-09-07 AP APAP/P/2000/001760A patent/AP2000001760A0/en unknown
- 1998-09-07 CN CN98810967A patent/CN1278821A/zh active Pending
- 1998-09-07 IL IL13493598A patent/IL134935A0/xx unknown
- 1998-09-07 US US09/508,326 patent/US6228853B1/en not_active Expired - Fee Related
- 1998-09-07 TR TR2000/01026T patent/TR200001026T2/xx unknown
- 1998-09-07 KR KR1020007002505A patent/KR20010023830A/ko not_active Application Discontinuation
- 1998-09-07 AU AU95360/98A patent/AU9536098A/en not_active Abandoned
- 1998-09-07 EA EA200000205A patent/EA200000205A1/ru unknown
- 1998-09-07 MA MA25244A patent/MA26544A1/fr unknown
- 1998-09-07 HU HU0003475A patent/HUP0003475A3/hu unknown
- 1998-09-07 EP EP98948905A patent/EP1019406A1/fr not_active Withdrawn
- 1998-09-07 EE EEP200000137A patent/EE200000137A/xx unknown
- 1998-09-07 SK SK324-2000A patent/SK3242000A3/sk unknown
-
2000
- 2000-03-03 IS IS5394A patent/IS5394A/is unknown
- 2000-03-08 NO NO20001200A patent/NO20001200L/no not_active Application Discontinuation
- 2000-03-09 HR HR20000136A patent/HRP20000136A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2303249A1 (fr) | 1999-03-18 |
WO1999012931A1 (fr) | 1999-03-18 |
CN1278821A (zh) | 2001-01-03 |
KR20010023830A (ko) | 2001-03-26 |
PL339186A1 (en) | 2000-12-04 |
AU9536098A (en) | 1999-03-29 |
HUP0003475A2 (hu) | 2001-09-28 |
SK3242000A3 (en) | 2001-03-12 |
GB9719187D0 (en) | 1997-11-12 |
JP2001515902A (ja) | 2001-09-25 |
EE200000137A (et) | 2001-02-15 |
EA200000205A1 (ru) | 2000-10-30 |
HUP0003475A3 (en) | 2002-01-28 |
NO20001200D0 (no) | 2000-03-08 |
ZA988162B (en) | 2000-03-22 |
BR9811651A (pt) | 2000-08-08 |
IS5394A (is) | 2000-03-03 |
NO20001200L (no) | 2000-05-08 |
EP1019406A1 (fr) | 2000-07-19 |
US6228853B1 (en) | 2001-05-08 |
AP2000001760A0 (en) | 2000-03-31 |
TR200001026T2 (tr) | 2000-09-21 |
HRP20000136A2 (en) | 2000-08-31 |
ID24364A (id) | 2000-07-13 |
IL134935A0 (en) | 2001-05-20 |
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