BRPI0919810A8 - Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos - Google Patents

Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos

Info

Publication number
BRPI0919810A8
BRPI0919810A8 BRPI0919810A BRPI0919810A BRPI0919810A8 BR PI0919810 A8 BRPI0919810 A8 BR PI0919810A8 BR PI0919810 A BRPI0919810 A BR PI0919810A BR PI0919810 A BRPI0919810 A BR PI0919810A BR PI0919810 A8 BRPI0919810 A8 BR PI0919810A8
Authority
BR
Brazil
Prior art keywords
nitrogen
preparation
equal
antibacterial drugs
heterocyclic compounds
Prior art date
Application number
BRPI0919810A
Other languages
English (en)
Inventor
Renaud Emilie
Lampilas Maxime
Rowlands David
Ledoussal Benoit
Gourdel Marie-Edith
Pierres Camille
Kebsi Adel
Original Assignee
Novexel
Astra Zeneca Holding France S A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40548019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0919810(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel, Astra Zeneca Holding France S A S filed Critical Novexel
Publication of BRPI0919810A2 publication Critical patent/BRPI0919810A2/pt
Publication of BRPI0919810A8 publication Critical patent/BRPI0919810A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS HETEROCÍCLICOS CONTENDO NITROGÊNIO, SUA PREPARAÇÃO E SEU USO COMO MEDICAMENTOS ANTIBACTERIANOS. A invenção relaciona-se a compostos heterocíclicos contendo nitrogênio de fórmula geral (1) em que: R1 representa um radical (CH2)n-NH2, n sendo igual a 1 ou 2; R2 representa um átomo de hidrogênio; R3 e R4 formam juntos um heterociclo contendo nitrogênio com aromaticidade com 5 ápices, contendo 1, 2 ou 3 átomos de nitrogênio, substituídos nesse átomo de nitrogênio ou em um desses átomos de nitrogênio por um grupo (CH2)m-(C{O))p-Rs, m sendo igual a O, 1, 2 ou 3, p sendo igual a O ou 1 e Rs representando um grupo hidróxi, em que p é igual a 1, ou um amino, (C1-C6)alquila de grupo di-(C1- C6)alquilamino ou um heterociclo contendo nitrogênio com aromaticidade com 5 ou 6 ápices contendo 1 ou 2 átomos de nitrogênio e, se necessário, um átomo de oxigênio ou enxofre; compreende-se que quando o subgrupo (C(O))p-Rs forma um grupo carbóxi, amino, (C1-C6)alquila ou di(C1-C6) lquilamino, m é diferente de O ou 1; na forma livre ou como zwitterions e sais com bases e ácidos minerais ou orgânicos farmaceuticamente aceitáveis, a sua preparação e a seu uso como medicamentos antibacterianos.
BRPI0919810A 2008-10-03 2009-08-03 Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos BRPI0919810A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0805472A FR2936798B1 (fr) 2008-10-03 2008-10-03 Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
PCT/IB2009/006433 WO2010038115A1 (fr) 2008-10-03 2009-08-03 Nouveaux composes heterocycliques azotes, leur préparation et leur utilisation comme médicaments antibactériens

Publications (2)

Publication Number Publication Date
BRPI0919810A2 BRPI0919810A2 (pt) 2017-10-31
BRPI0919810A8 true BRPI0919810A8 (pt) 2017-12-12

Family

ID=40548019

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919810A BRPI0919810A8 (pt) 2008-10-03 2009-08-03 Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos

Country Status (18)

Country Link
US (1) US8067435B2 (pt)
EP (2) EP2344499A1 (pt)
JP (1) JP5555240B2 (pt)
KR (1) KR20110067137A (pt)
CN (1) CN102203094B (pt)
AU (1) AU2009299511A1 (pt)
BR (1) BRPI0919810A8 (pt)
CA (1) CA2739503A1 (pt)
CL (1) CL2011000729A1 (pt)
CO (1) CO6361957A2 (pt)
EA (1) EA021799B1 (pt)
EC (1) ECSP11010946A (pt)
FR (1) FR2936798B1 (pt)
IL (1) IL212059A0 (pt)
MX (1) MX2011003573A (pt)
PE (1) PE20110845A1 (pt)
WO (1) WO2010038115A1 (pt)
ZA (1) ZA201102429B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
EP2872510B1 (en) 2011-08-30 2016-11-23 Wockhardt Limited 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections
BR112014003476A2 (pt) * 2011-09-13 2017-03-01 Wockhardt Ltd compostos contendo nitrogênio e seu uso
SG11201406120SA (en) * 2012-03-30 2014-10-30 Cubist Pharm Inc ISOXAZOLE β-LACTAMASE INHIBITORS
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
PL2857401T3 (pl) * 2012-05-30 2020-02-28 Meiji Seika Pharma Co., Ltd. NOWY INHIBITOR ß–LAKTAMAZY I SPOSÓB JEGO WYTWARZANIA
BR112015003592B1 (pt) * 2012-08-25 2020-04-14 Wockhardt Ltd derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas
TWI644908B (zh) 2013-09-24 2018-12-21 明治製菓藥業股份有限公司 二氮雜二環辛烷衍生物之製法及其中間體
EP3067355B1 (en) 2013-10-08 2020-12-16 Meiji Seika Pharma Co., Ltd. Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative
IN2013MU03216A (pt) * 2013-10-11 2015-07-03 Wockhardt Ltd
KR102542392B1 (ko) 2014-11-17 2023-06-09 엔타시스 테라퓨틱스 리미티드 내성 박테리아 감염의 치료를 위한 배합물 치료제
JP6779787B2 (ja) 2014-12-05 2020-11-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法
EP3075733A1 (en) * 2015-03-31 2016-10-05 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
CA2980085A1 (en) * 2015-03-31 2016-10-06 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
TW201639854A (zh) * 2015-04-03 2016-11-16 木塔比利斯公司 雜環化合物及其用於預防或治療細菌感染的用途
US9951072B2 (en) 2015-10-02 2018-04-24 Legochem Biosciences, Inc. Compositions and methods for inhibiting beta-lactamase
KR102667828B1 (ko) 2016-09-16 2024-05-20 엔타시스 테라퓨틱스 리미티드 베타-락타마제 억제제 화합물
MX2019013291A (es) 2017-05-08 2020-01-15 Entasis Therapeutics Inc Compuestos y metodos para tratar infecciones bacterianas.
EP3604315A1 (en) * 2018-07-30 2020-02-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0100051A3 (en) * 1997-09-15 2002-08-28 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
WO2002048138A1 (en) * 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones
PL363301A1 (en) * 2000-12-14 2004-11-15 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2844270B1 (fr) * 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) * 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7232833B2 (en) * 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens

Also Published As

Publication number Publication date
IL212059A0 (en) 2011-06-30
ZA201102429B (en) 2012-05-30
JP5555240B2 (ja) 2014-07-23
FR2936798A1 (fr) 2010-04-09
EA201170522A1 (ru) 2011-12-30
EP2344499A1 (fr) 2011-07-20
CA2739503A1 (fr) 2010-04-08
CO6361957A2 (es) 2012-01-20
CL2011000729A1 (es) 2012-07-06
AU2009299511A1 (en) 2010-04-08
JP2012504593A (ja) 2012-02-23
US20100087648A1 (en) 2010-04-08
US8067435B2 (en) 2011-11-29
KR20110067137A (ko) 2011-06-21
ECSP11010946A (es) 2011-05-31
WO2010038115A1 (fr) 2010-04-08
PE20110845A1 (es) 2011-11-17
EP2845855A1 (fr) 2015-03-11
CN102203094A (zh) 2011-09-28
MX2011003573A (es) 2011-08-12
BRPI0919810A2 (pt) 2017-10-31
CN102203094B (zh) 2014-04-02
EA021799B1 (ru) 2015-09-30
FR2936798B1 (fr) 2012-09-28

Similar Documents

Publication Publication Date Title
BRPI0919810A8 (pt) Compostos heterocíclicos contendo nitrogênio, sua preparação e seu uso como medicamentos antibacterianos
MX2011011485A (es) Sulfonamidas nematocidas.
HN2009000502A (es) DERIVADOS DE 2- ARIL-6-FENIL-IMIDAZO[ 1,2-a] PIRIDINAS SU PREPARACION Y SU APLICACION EN TERAPEUTICA
MX343596B (es) Sulfonamidas nematocidas.
BRPI1008498B8 (pt) compostos de piridazinona úteis como inibidores da fosfodiesterase 10a, composição farmacêutica, e, uso de um composto
AR067757A1 (es) Derivados de imidazo[4,5-c]piridin-2-ona, composiciones farmaceuticas que los contienen, procedimiento para su preparacion y uso de los mismos como agentes antivirales.
BRPI0921701B8 (pt) Cefarosporina tendo um grupo catecol, seu uso e composição farmacêutica que a compreende
BRPI1013821A8 (pt) piridinas substituídas como antagonistas de ccr3.
BR112015009777A2 (pt) derivado de amina ou sal do mesmo
CO6640247A2 (es) Compuesto[5.6]heterociclico o una sal farmacológicamente aceptable del mismo útil para la prevención de enfermedades asociadas con el metabolismo óseo
BR112014024279A8 (pt) Compostos heterobicíclicos como inibidores de beta-lactamase, composição farmacêutica, uso de um composto
BR112015015275A8 (pt) composto heterocíclico substituído por halogênio, antagonista do receptor de lpa, composição farmacêutica e uso
BRPI1011657A2 (pt) derivados aminopropiônicos substituídos como inibidores de neprilisina
BRPI0814231B8 (pt) derivados de pleuromutilina, seu uso e composição farmacêutica
BR112012033770A2 (pt) novo derivado de nicotinamida ou sal do mesmo
CO6251282A2 (es) Oxazolidinonas sustituidas y su uso
BR112018011788A2 (pt) formas sólidas de éster etílico de ácido (2r,4s)-5-(bifenil-4-il)-4-[(3-carboxipropionil)amino]-2-metil-pentanoico, seus sais e um método de preparação
NO20092224L (no) Quiniklidinderivater av (hetero)arylcykloheptankarboksylsyre som muskarinreseptorantagonister
AR078278A1 (es) Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
AR074608A1 (es) Derivados de 2-(piperidin-1-il)-4-heterociclil-tiazol-5-carboxilico para infecciones bacterianas
ECSP13012664A (es) Formas cristalinas de la sal clorhidrato de (4a-r,9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1h-inden[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de hsd 1
NI200900181A (es) Nuevos compuestos heterocíclicos nitrogenados, su preparación y su utilización como medicamentos antibacterianos.
BRPI0919812A8 (pt) Combinações de compostos antibacterianos heterocíclicos hirdrogenados com outros compostos antibacterianos e o uso dos mesmos como medicamentos
CO2019004978A2 (es) Compuestos terapéuticos y métodos para utilizarlos
BRPI0511999A (pt) compostos como antagonistas de ccr5

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: ASTRA ZENECA HOLDING FRANCE S.A.S. (FR)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]