CN102203094B - 含氮杂环化合物,其制备及其作为抗菌药物的用途 - Google Patents
含氮杂环化合物,其制备及其作为抗菌药物的用途 Download PDFInfo
- Publication number
- CN102203094B CN102203094B CN200980141781.3A CN200980141781A CN102203094B CN 102203094 B CN102203094 B CN 102203094B CN 200980141781 A CN200980141781 A CN 200980141781A CN 102203094 B CN102203094 B CN 102203094B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
分子 | MIC(μg/mL)24h(绿脓杆菌,1771) |
实施例1 | 0.25 |
实施例2 | 2 |
实施例3 | 2 |
实施例4 | 0.25 |
实施例5 | 0.25 |
实施例6 | 8 |
实施例7 | 4 |
实施例8 | 0.5 |
WO 04/052891号专利申请的实施例7 | >128 |
WO 04/052891号专利申请的实施例9 | >128 |
WO 04/052891号专利申请的实施例11 | >128 |
WO 04/052891号专利申请的实施例45 | >128 |
IMP | 1 |
CAZ | 1 |
Claims (3)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0805472A FR2936798B1 (fr) | 2008-10-03 | 2008-10-03 | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
FR0805472 | 2008-10-03 | ||
PCT/IB2009/006433 WO2010038115A1 (fr) | 2008-10-03 | 2009-08-03 | Nouveaux composes heterocycliques azotes, leur préparation et leur utilisation comme médicaments antibactériens |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102203094A CN102203094A (zh) | 2011-09-28 |
CN102203094B true CN102203094B (zh) | 2014-04-02 |
Family
ID=40548019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980141781.3A Expired - Fee Related CN102203094B (zh) | 2008-10-03 | 2009-08-03 | 含氮杂环化合物,其制备及其作为抗菌药物的用途 |
Country Status (18)
Country | Link |
---|---|
US (1) | US8067435B2 (zh) |
EP (2) | EP2344499A1 (zh) |
JP (1) | JP5555240B2 (zh) |
KR (1) | KR20110067137A (zh) |
CN (1) | CN102203094B (zh) |
AU (1) | AU2009299511A1 (zh) |
BR (1) | BRPI0919810A8 (zh) |
CA (1) | CA2739503A1 (zh) |
CL (1) | CL2011000729A1 (zh) |
CO (1) | CO6361957A2 (zh) |
EA (1) | EA021799B1 (zh) |
EC (1) | ECSP11010946A (zh) |
FR (1) | FR2936798B1 (zh) |
IL (1) | IL212059A0 (zh) |
MX (1) | MX2011003573A (zh) |
PE (1) | PE20110845A1 (zh) |
WO (1) | WO2010038115A1 (zh) |
ZA (1) | ZA201102429B (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
CN103649088B (zh) * | 2011-08-30 | 2016-05-11 | 沃克哈特有限公司 | 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途 |
ES2640520T3 (es) * | 2011-09-13 | 2017-11-03 | Wockhardt Limited | Compuestos que contienen nitrógeno y su uso |
KR20150003777A (ko) * | 2012-03-30 | 2015-01-09 | 큐비스트 파마슈티컬즈 인코포레이티드 | 이속사졸 β-락타마제 억제제 |
AR090539A1 (es) * | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
MX366948B (es) * | 2012-05-30 | 2019-07-30 | Meiji Seika Pharma Co Ltd | Nuevo inhibidor de beta-lactamasa y proceso para prepararlo. |
WO2014033560A1 (en) * | 2012-08-25 | 2014-03-06 | Wockhardt Limited | 1,6- diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections |
KR102239725B1 (ko) | 2013-09-24 | 2021-04-12 | 메이지 세이카 파루마 가부시키가이샤 | 디아자비시클로옥탄 유도체의 제조법과 그의 중간체 |
ES2842225T3 (es) | 2013-10-08 | 2021-07-13 | Meiji Seika Pharma Co Ltd | Cristales de derivado de diazabiciclooctano y método de producción para cristales de derivado de diazabiciclooctano |
RU2016113755A (ru) * | 2013-10-11 | 2017-11-16 | Вокхардт Лимитед | Азотсодержащие соединения и их применение |
AU2015350128B2 (en) | 2014-11-17 | 2019-05-16 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
WO2016088863A1 (ja) | 2014-12-05 | 2016-06-09 | Meiji Seikaファルマ株式会社 | ジアザビシクロオクタン誘導体の結晶及び安定な凍結乾燥製剤の製造法 |
JP2018510202A (ja) * | 2015-03-31 | 2018-04-12 | ミュタビリスMutabilis | 新規の複素環化合物及び細菌感染を予防又は治療する際のそれらの使用 |
EP3075733A1 (en) * | 2015-03-31 | 2016-10-05 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
KR20170132316A (ko) | 2015-04-03 | 2017-12-01 | 무타빌리스 | 헤테로고리 화합물 및 박테리아 감염의 예방 또는 치료에서 그들의 용도 |
US9951072B2 (en) | 2015-10-02 | 2018-04-24 | Legochem Biosciences, Inc. | Compositions and methods for inhibiting beta-lactamase |
KR102537340B1 (ko) | 2016-09-16 | 2023-05-26 | 엔타시스 테라퓨틱스 리미티드 | 베타-락타마제 억제제 화합물 |
PE20200333A1 (es) | 2017-05-08 | 2020-02-14 | Entasis Therapeutics Inc | Compuestos y metodos para tratar infecciones bacterianas |
EP3604315A1 (en) * | 2018-07-30 | 2020-02-05 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100860A2 (fr) * | 2001-06-08 | 2002-12-19 | Aventis Pharma S.A. | Composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
WO2004052891A1 (fr) * | 2002-12-06 | 2004-06-24 | Aventis Pharma S.A. | Composes heterocyclique, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6387928B1 (en) | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
WO1999014214A1 (en) | 1997-09-15 | 1999-03-25 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
CA2427872A1 (en) | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Antimicrobial 2-pyridones, their compositions and uses |
AU3089102A (en) | 2000-12-14 | 2002-06-24 | Procter & Gamble | Antimicrobial quinolones |
FR2833596B1 (fr) | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
US6900224B2 (en) | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
FR2844273B1 (fr) | 2002-09-05 | 2008-04-04 | Aventis Pharma Sa | Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens. |
FR2844270B1 (fr) | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
FR2844268B1 (fr) | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
US7439253B2 (en) | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
US7232833B2 (en) | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
US7449481B2 (en) | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
FR2914923B1 (fr) * | 2007-04-12 | 2013-06-14 | Novexel | Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens. |
FR2937034B1 (fr) * | 2008-10-10 | 2012-11-23 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens |
-
2008
- 2008-10-03 FR FR0805472A patent/FR2936798B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-03 KR KR1020117009615A patent/KR20110067137A/ko not_active Application Discontinuation
- 2009-08-03 PE PE2011000827A patent/PE20110845A1/es not_active Application Discontinuation
- 2009-08-03 CA CA2739503A patent/CA2739503A1/fr not_active Abandoned
- 2009-08-03 MX MX2011003573A patent/MX2011003573A/es active IP Right Grant
- 2009-08-03 EP EP09786093A patent/EP2344499A1/fr not_active Withdrawn
- 2009-08-03 EP EP14188601.0A patent/EP2845855A1/fr not_active Withdrawn
- 2009-08-03 CN CN200980141781.3A patent/CN102203094B/zh not_active Expired - Fee Related
- 2009-08-03 WO PCT/IB2009/006433 patent/WO2010038115A1/fr active Application Filing
- 2009-08-03 EA EA201170522A patent/EA021799B1/ru not_active IP Right Cessation
- 2009-08-03 JP JP2011529643A patent/JP5555240B2/ja not_active Expired - Fee Related
- 2009-08-03 AU AU2009299511A patent/AU2009299511A1/en not_active Abandoned
- 2009-08-03 BR BRPI0919810A patent/BRPI0919810A8/pt not_active IP Right Cessation
- 2009-08-05 US US12/536,096 patent/US8067435B2/en not_active Expired - Fee Related
-
2011
- 2011-03-30 ZA ZA2011/02429A patent/ZA201102429B/en unknown
- 2011-03-31 IL IL212059A patent/IL212059A0/en unknown
- 2011-04-01 EC EC2011010946A patent/ECSP11010946A/es unknown
- 2011-04-01 CL CL2011000729A patent/CL2011000729A1/es unknown
- 2011-04-01 CO CO11040684A patent/CO6361957A2/es active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002100860A2 (fr) * | 2001-06-08 | 2002-12-19 | Aventis Pharma S.A. | Composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
WO2004052891A1 (fr) * | 2002-12-06 | 2004-06-24 | Aventis Pharma S.A. | Composes heterocyclique, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
Also Published As
Publication number | Publication date |
---|---|
WO2010038115A1 (fr) | 2010-04-08 |
MX2011003573A (es) | 2011-08-12 |
CL2011000729A1 (es) | 2012-07-06 |
JP2012504593A (ja) | 2012-02-23 |
EA021799B1 (ru) | 2015-09-30 |
KR20110067137A (ko) | 2011-06-21 |
FR2936798B1 (fr) | 2012-09-28 |
EP2344499A1 (fr) | 2011-07-20 |
FR2936798A1 (fr) | 2010-04-09 |
EP2845855A1 (fr) | 2015-03-11 |
US8067435B2 (en) | 2011-11-29 |
US20100087648A1 (en) | 2010-04-08 |
BRPI0919810A2 (pt) | 2017-10-31 |
CN102203094A (zh) | 2011-09-28 |
BRPI0919810A8 (pt) | 2017-12-12 |
PE20110845A1 (es) | 2011-11-17 |
CO6361957A2 (es) | 2012-01-20 |
AU2009299511A1 (en) | 2010-04-08 |
IL212059A0 (en) | 2011-06-30 |
CA2739503A1 (fr) | 2010-04-08 |
EA201170522A1 (ru) | 2011-12-30 |
ECSP11010946A (es) | 2011-05-31 |
JP5555240B2 (ja) | 2014-07-23 |
ZA201102429B (en) | 2012-05-30 |
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