BR0111986A - Derivados de 2-aminotiazolina e sua utilização como inibidores de no-sintase - Google Patents

Derivados de 2-aminotiazolina e sua utilização como inibidores de no-sintase

Info

Publication number
BR0111986A
BR0111986A BR0111986-9A BR0111986A BR0111986A BR 0111986 A BR0111986 A BR 0111986A BR 0111986 A BR0111986 A BR 0111986A BR 0111986 A BR0111986 A BR 0111986A
Authority
BR
Brazil
Prior art keywords
radical
pyridyl
derivatives
alkyl
phenyl
Prior art date
Application number
BR0111986-9A
Other languages
English (en)
Inventor
Jean-Christophe Carry
Dominique Damour
Claude Guyon
Serge Mignani
Antony Bigot
Eric Bacque
Michel Tabart
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0111986A publication Critical patent/BR0111986A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE 2-AMINOTIAZOLINA E SUA UTILIZAçãO COMO INIBIDORES DE NO-SINTASE". A presente invenção refere-se aos derivados de 2-aminotiazolina de fórmula (I), na qual R~ 1~ é um átomo de hidrogênio ou um radical alquila e R~ 2~ é um radical alila, -alq-NH~ 2~, -CH~ 2~-S-R~ 4~ ou fenila substituído por um radical nitro ou -NH-C-(=NH)CH~ 3~, seja R~ 1~ é um radical alquila e R~ 2~ é um átomo de hidrogênio, R~ 3~ é um radical cicloalquila (3-6C), piridila, N-óxido de piridila, tienila, tiazolila, imidazolila, pirazinila, triazolila, fenila ou fenila substituído por um radical nitro, hidróxi, ou carbóxi, R~ 4~ representa um radical piridila ou N-óxido de piridila, alquila representa um radical alquileno ou seus sais farmaceuticamente aceitáveis, com exclusão de certos compostos conhecidos, assim como a utilização desses derivados como inibidores de NO-sintase indutível.
BR0111986-9A 2000-06-09 2001-06-07 Derivados de 2-aminotiazolina e sua utilização como inibidores de no-sintase BR0111986A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0007397A FR2810037B1 (fr) 2000-06-09 2000-06-09 Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible
PCT/FR2001/001760 WO2001094325A1 (fr) 2000-06-09 2001-06-07 Derives de 2-aminothiazoline et leur utilisation comme inhibiteurs de no-synthase

Publications (1)

Publication Number Publication Date
BR0111986A true BR0111986A (pt) 2003-04-01

Family

ID=8851134

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111986-9A BR0111986A (pt) 2000-06-09 2001-06-07 Derivados de 2-aminotiazolina e sua utilização como inibidores de no-sintase

Country Status (29)

Country Link
EP (1) EP1299365B1 (pt)
JP (1) JP4238026B2 (pt)
KR (1) KR20030025931A (pt)
CN (1) CN1202096C (pt)
AP (1) AP2002002708A0 (pt)
AR (1) AR029937A1 (pt)
AT (1) ATE305460T1 (pt)
AU (1) AU2001266124A1 (pt)
BR (1) BR0111986A (pt)
CA (1) CA2411760C (pt)
DE (1) DE60113689T2 (pt)
DK (1) DK1299365T3 (pt)
DZ (1) DZ3367A1 (pt)
EA (1) EA200300010A1 (pt)
EC (1) ECSP024375A (pt)
ES (1) ES2248347T3 (pt)
FR (1) FR2810037B1 (pt)
HK (1) HK1057900A1 (pt)
HR (1) HRP20020970A2 (pt)
HU (1) HUP0301000A2 (pt)
IL (1) IL153328A0 (pt)
MA (1) MA25814A1 (pt)
MX (1) MXPA02012071A (pt)
NO (1) NO20025884L (pt)
NZ (1) NZ522968A (pt)
OA (1) OA12286A (pt)
PL (1) PL360285A1 (pt)
WO (1) WO2001094325A1 (pt)
ZA (1) ZA200209769B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2337654T3 (es) * 2001-09-26 2010-04-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Esfingolipidos.
CA2465691C (fr) * 2001-11-09 2011-07-19 Aventis Pharma S.A. Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
CA2465877C (fr) * 2001-11-09 2009-12-29 Aventis Pharma S.A. Utilisation de derives de 2-amino-4-pyridylmethyl-thiazoline comme inhibiteurs de non-synthase inductible
DE60209806T2 (de) * 2001-11-09 2006-11-02 Aventis Pharma S.A. 2-amino-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthase
AU2002238889A1 (en) * 2002-03-14 2003-09-22 Dainippon Pharmaceutical Co., Ltd. Nitrogen monoxide synthase inhibitors
DK1539724T3 (da) * 2002-08-07 2008-02-11 Neuraxon Inc Aminobenzothiazolforbindelser med NOS-inhiberende aktivitet
DE10332560B4 (de) * 2003-07-11 2010-07-08 Chiracon Gmbh Verfahren zur Herstellung von ß- Heteroaryl-2-alanin-Verbindungen über 2-Amino-2-(heteroarylmethyl)-carbonsäure-Verbindungen
KR101800507B1 (ko) 2015-09-18 2018-01-18 주식회사 이엔이티아이 자동세척 스크린과 식물정화장치를 활용하여 지속적으로 유입되는 생활하수나 공정폐수가 유입되는 오염하천정화를 위한 방법 및 그 장치

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066662A (en) * 1990-05-21 1991-11-19 Warner-Lambert Company Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors
SI9300616A (en) * 1992-11-27 1994-06-30 Wellcome Found Enzyme inhibitors
DE69416848T2 (de) * 1993-10-21 1999-07-08 Searle & Co Amidino-derivate als no-synthetase inhibitoren
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
WO2001047931A1 (fr) * 1999-12-24 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Derives de purine fondue

Also Published As

Publication number Publication date
FR2810037B1 (fr) 2004-04-23
AU2001266124A1 (en) 2001-12-17
EA200300010A1 (ru) 2003-06-26
DZ3367A1 (fr) 2001-12-13
NZ522968A (en) 2005-07-29
CA2411760C (fr) 2009-12-29
ES2248347T3 (es) 2006-03-16
JP2003535853A (ja) 2003-12-02
DE60113689D1 (de) 2006-02-09
CN1444572A (zh) 2003-09-24
ZA200209769B (en) 2004-03-02
ECSP024375A (es) 2003-02-06
JP4238026B2 (ja) 2009-03-11
AP2002002708A0 (en) 2002-12-31
ATE305460T1 (de) 2005-10-15
PL360285A1 (en) 2004-09-06
CN1202096C (zh) 2005-05-18
HRP20020970A2 (en) 2005-02-28
MXPA02012071A (es) 2004-09-10
IL153328A0 (en) 2003-07-06
EP1299365B1 (fr) 2005-09-28
DE60113689T2 (de) 2006-07-13
OA12286A (en) 2006-05-12
DK1299365T3 (da) 2006-02-06
NO20025884D0 (no) 2002-12-06
EP1299365A1 (fr) 2003-04-09
MA25814A1 (fr) 2003-07-01
KR20030025931A (ko) 2003-03-29
NO20025884L (no) 2003-01-29
FR2810037A1 (fr) 2001-12-14
CA2411760A1 (fr) 2001-12-13
HK1057900A1 (en) 2004-04-23
WO2001094325A1 (fr) 2001-12-13
HUP0301000A2 (hu) 2003-08-28
AR029937A1 (es) 2003-07-23

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 277/18, C07D 417/06, C07D 417/12, C07D 277/28, A61K 31/426, A61K 31/427, A61K 31/4439, A61K 31/497, A61P 25/00, C07D 213/38, C07D 213/40, C07D 333/20, C07D 241/12, C07D 213/70, C07D 213/89, C07C 335/06, C07C 215/00, C07C 229/00, C07C 233/00, C07C 271/00, C07C 333/00

Ipc: C07D 277/18 (2010.01), C07D 277/28 (2010.01), C07D

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements