IL161842A0 - 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase - Google Patents

2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase

Info

Publication number
IL161842A0
IL161842A0 IL16184202A IL16184202A IL161842A0 IL 161842 A0 IL161842 A0 IL 161842A0 IL 16184202 A IL16184202 A IL 16184202A IL 16184202 A IL16184202 A IL 16184202A IL 161842 A0 IL161842 A0 IL 161842A0
Authority
IL
Israel
Prior art keywords
heteroarylethyl
synthase
inducible
inhibitors
amino
Prior art date
Application number
IL16184202A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114509A external-priority patent/FR2832151B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of IL161842A0 publication Critical patent/IL161842A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL16184202A 2001-11-09 2002-11-07 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase IL161842A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0114509A FR2832151B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297702P 2002-01-30 2002-01-30
PCT/FR2002/003809 WO2003040142A1 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible

Publications (1)

Publication Number Publication Date
IL161842A0 true IL161842A0 (en) 2005-11-20

Family

ID=26213259

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16184202A IL161842A0 (en) 2001-11-09 2002-11-07 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase
IL161842A IL161842A (en) 2001-11-09 2004-05-06 2-amino-4-heteroarylethyl-thiazoline derivatives and pharmaceutical compositions comprising them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL161842A IL161842A (en) 2001-11-09 2004-05-06 2-amino-4-heteroarylethyl-thiazoline derivatives and pharmaceutical compositions comprising them

Country Status (19)

Country Link
US (1) US6872740B2 (pt)
EP (1) EP1446402B1 (pt)
JP (1) JP4365681B2 (pt)
AT (1) ATE308541T1 (pt)
AU (1) AU2002358874B2 (pt)
BR (1) BR0206363A (pt)
CA (1) CA2465691C (pt)
DE (1) DE60207104T2 (pt)
DK (1) DK1446402T3 (pt)
ES (1) ES2250731T3 (pt)
HR (1) HRP20040401A2 (pt)
HU (1) HUP0402038A2 (pt)
IL (2) IL161842A0 (pt)
MA (1) MA27077A1 (pt)
MX (1) MXPA04003766A (pt)
NO (1) NO20033130L (pt)
PL (1) PL370322A1 (pt)
RU (1) RU2004117525A (pt)
WO (1) WO2003040142A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60209806T2 (de) * 2001-11-09 2006-11-02 Aventis Pharma S.A. 2-amino-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthase
RU2416603C9 (ru) 2005-10-25 2012-06-20 Сионоги Энд Ко., Лтд. Производные аминодигидротиазина
ES2476605T3 (es) 2007-04-24 2014-07-15 Shionogi & Co., Ltd. Derivados de aminohidrotiazina sustituidos con grupos cíclicos
WO2008133273A1 (ja) 2007-04-24 2008-11-06 Shionogi & Co., Ltd. アルツハイマー症治療用医薬組成物
NZ589590A (en) 2008-06-13 2012-05-25 Shionogi & Co Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
WO2010047372A1 (ja) 2008-10-22 2010-04-29 塩野義製薬株式会社 Bace1阻害活性を有する2-アミノピリミジン-4-オンおよび2-アミノピリジン誘導体
RU2012129168A (ru) * 2009-12-11 2014-01-20 Сионоги Энд Ко. Лтд. Производные оксазина
AU2011321427A1 (en) 2010-10-29 2013-05-02 Shionogi & Co., Ltd. Naphthyridine derivative
EP2634188A4 (en) 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
EP2703399A4 (en) 2011-04-26 2014-10-15 Shionogi & Co OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF
EP2912035A4 (en) 2012-10-24 2016-06-15 Shionogi & Co DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY
US9968576B2 (en) 2014-10-24 2018-05-15 Korea Institute Of Ocean Science And Technology Composition for preventing or treating neurodegenerative diseases, containing Ramalin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300616A (en) * 1992-11-27 1994-06-30 Wellcome Found Enzyme inhibitors
DE69416848T2 (de) * 1993-10-21 1999-07-08 Searle & Co Amidino-derivate als no-synthetase inhibitoren
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

Also Published As

Publication number Publication date
CA2465691C (fr) 2011-07-19
DE60207104D1 (de) 2005-12-08
MA27077A1 (fr) 2004-12-20
HUP0402038A2 (hu) 2005-01-28
PL370322A1 (en) 2005-05-16
ATE308541T1 (de) 2005-11-15
NO20033130L (no) 2003-08-27
US6872740B2 (en) 2005-03-29
DE60207104T2 (de) 2006-07-13
CA2465691A1 (fr) 2003-05-15
RU2004117525A (ru) 2005-04-20
AU2002358874B2 (en) 2007-09-06
HRP20040401A2 (en) 2004-10-31
US20030225140A1 (en) 2003-12-04
WO2003040142A1 (fr) 2003-05-15
JP2005509651A (ja) 2005-04-14
IL161842A (en) 2010-12-30
MXPA04003766A (es) 2004-07-29
JP4365681B2 (ja) 2009-11-18
ES2250731T3 (es) 2006-04-16
NO20033130D0 (no) 2003-07-08
EP1446402B1 (fr) 2005-11-02
BR0206363A (pt) 2003-12-23
EP1446402A1 (fr) 2004-08-18
DK1446402T3 (da) 2006-03-06

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