FR2832151B1 - Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible - Google Patents

Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible

Info

Publication number
FR2832151B1
FR2832151B1 FR0114509A FR0114509A FR2832151B1 FR 2832151 B1 FR2832151 B1 FR 2832151B1 FR 0114509 A FR0114509 A FR 0114509A FR 0114509 A FR0114509 A FR 0114509A FR 2832151 B1 FR2832151 B1 FR 2832151B1
Authority
FR
France
Prior art keywords
inductible
heteroarylethyl
amino
synthase inhibitors
thiazoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0114509A
Other languages
English (en)
Other versions
FR2832151A1 (fr
Inventor
Eric Bacque
Antony Bigot
Jean Christophe Carry
Serge Mignani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to FR0114509A priority Critical patent/FR2832151B1/fr
Priority to ARP020104127A priority patent/AR037509A1/es
Priority to EP02793211A priority patent/EP1446402B1/fr
Priority to ES02793211T priority patent/ES2250731T3/es
Priority to CN028245164A priority patent/CN1871234B/zh
Priority to CA2465691A priority patent/CA2465691C/fr
Priority to IL16184202A priority patent/IL161842A0/xx
Priority to PCT/FR2002/003809 priority patent/WO2003040142A1/fr
Priority to RU2004117525/04A priority patent/RU2004117525A/ru
Priority to AT02793211T priority patent/ATE308541T1/de
Priority to JP2003542188A priority patent/JP4365681B2/ja
Priority to HU0402038A priority patent/HUP0402038A2/hu
Priority to PL02370322A priority patent/PL370322A1/xx
Priority to BR0206363-8A priority patent/BR0206363A/pt
Priority to MXPA04003766A priority patent/MXPA04003766A/es
Priority to DE60207104T priority patent/DE60207104T2/de
Priority to AU2002358874A priority patent/AU2002358874B2/en
Priority to DK02793211T priority patent/DK1446402T3/da
Priority to US10/291,110 priority patent/US6872740B2/en
Publication of FR2832151A1 publication Critical patent/FR2832151A1/fr
Priority to NO20033130A priority patent/NO20033130L/no
Priority to MA27645A priority patent/MA27077A1/fr
Priority to ZA200403400A priority patent/ZA200403400B/en
Priority to HR20040401A priority patent/HRP20040401A2/hr
Priority to IL161842A priority patent/IL161842A/en
Application granted granted Critical
Publication of FR2832151B1 publication Critical patent/FR2832151B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR0114509A 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible Expired - Fee Related FR2832151B1 (fr)

Priority Applications (24)

Application Number Priority Date Filing Date Title
FR0114509A FR2832151B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible
ARP020104127A AR037509A1 (es) 2001-11-09 2002-10-30 Un compuesto de 2-amino-4-heteroariletil-tiazolina, un procedimiento para su preparacion, composicion farmaceutica, medicamento y compuestos intermediarios
DE60207104T DE60207104T2 (de) 2001-11-09 2002-11-07 2-amino-4-heteroarylethyl-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthase
CN028245164A CN1871234B (zh) 2001-11-09 2002-11-07 2-氨基-4-杂芳基乙基-二氢噻唑衍生物及其作为诱导型no-合酶抑制剂的用途
CA2465691A CA2465691C (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
IL16184202A IL161842A0 (en) 2001-11-09 2002-11-07 2-Amino-4-heteroarylethyl-thiazoline derivatives and their use as inhibitors of inducible no-synthase
PCT/FR2002/003809 WO2003040142A1 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
RU2004117525/04A RU2004117525A (ru) 2001-11-09 2002-11-07 Применение производных 2-амино-4-гетероариэтилтиазолина в качестве ингибиторов индуцибельной no-синтазы
AT02793211T ATE308541T1 (de) 2001-11-09 2002-11-07 2-amino-4-heteroarylethyl-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthase
JP2003542188A JP4365681B2 (ja) 2001-11-09 2002-11-07 ２−アミノ−４−ヘテロアリールエチル−チアゾリン誘導体および誘導型ｎｏシンターゼの阻害剤としてのその使用
HU0402038A HUP0402038A2 (hu) 2001-11-09 2002-11-07 2-Amino-4-heteroaril-etil-tiazolin-származékok alkalmazása az indukálható NO-szintetáz inhibitoraként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
PL02370322A PL370322A1 (en) 2001-11-09 2002-11-07 2-amino-4-heteroarylethyl thiazoline derivatives and their use an inhibitors of inducible no-synthase
EP02793211A EP1446402B1 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
MXPA04003766A MXPA04003766A (es) 2001-11-09 2002-11-07 Derivados de 2-amino-4-heteroariletil tiazolina y su utilizacion como inhibidores de no sintasa inducible.
ES02793211T ES2250731T3 (es) 2001-11-09 2002-11-07 Derivados de 2-amino-4-heteroariletil tiazolina y su utilizacion como inhibidores de no-sintasa inductible.
AU2002358874A AU2002358874B2 (en) 2001-11-09 2002-11-07 2-amino-4-heteroarylethyl thiazoline derivatives and their use an inhibitors of inducible no-synthase
DK02793211T DK1446402T3 (da) 2001-11-09 2002-11-07 2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase
BR0206363-8A BR0206363A (pt) 2001-11-09 2002-11-07 Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel
US10/291,110 US6872740B2 (en) 2001-11-09 2002-11-08 Use of 2-amino-4-heteroarylethyl-thiazoline derivatives as inhibitors of inducible no-synthase
NO20033130A NO20033130L (no) 2001-11-09 2003-07-08 Anvendelse av 2-amino-4-heteroaryletyl-tiazolin som inhibitorer av induktibel NO-syntase
MA27645A MA27077A1 (fr) 2001-11-09 2004-04-22 Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible
ZA200403400A ZA200403400B (en) 2001-11-09 2004-05-05 2-Amino-4-heteroarylethyl thiazole derivatives and their use as inhibitors of inducible NO-synthase.
HR20040401A HRP20040401A2 (en) 2001-11-09 2004-05-06 2-amino-4-heteroarylethyl thiazoline derivatives and their use an inhibitors of inducible no-synthase
IL161842A IL161842A (en) 2001-11-09 2004-05-06 2-amino-4-heteroarylethyl-thiazoline derivatives and pharmaceutical compositions comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0114509A FR2832151B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible

Publications (2)

Publication Number Publication Date
FR2832151A1 FR2832151A1 (fr) 2003-05-16
FR2832151B1 true FR2832151B1 (fr) 2004-12-17

Family

ID=8869232

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0114509A Expired - Fee Related FR2832151B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible

Country Status (4)

Country Link
CN (1) CN1871234B (fr)
AR (1) AR037509A1 (fr)
FR (1) FR2832151B1 (fr)
ZA (1) ZA200403400B (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
CN1077886C (zh) * 1993-10-21 2002-01-16 G·D·瑟尔公司 用作一氧化一氮合酶抑制剂的脒基衍生物
AU4149696A (en) * 1994-11-15 1996-06-06 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
FR2832151A1 (fr) 2003-05-16
AR037509A1 (es) 2004-11-17
CN1871234A (zh) 2006-11-29
ZA200403400B (en) 2005-01-20
CN1871234B (zh) 2010-06-16

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20060731