ATE308541T1 - 2-amino-4-heteroarylethyl-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthase - Google Patents
2-amino-4-heteroarylethyl-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthaseInfo
- Publication number
- ATE308541T1 ATE308541T1 AT02793211T AT02793211T ATE308541T1 AT E308541 T1 ATE308541 T1 AT E308541T1 AT 02793211 T AT02793211 T AT 02793211T AT 02793211 T AT02793211 T AT 02793211T AT E308541 T1 ATE308541 T1 AT E308541T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroarylethyl
- synthase
- inducible
- amino
- inhibiters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0114509A FR2832151B1 (fr) | 2001-11-09 | 2001-11-09 | Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible |
US35297702P | 2002-01-30 | 2002-01-30 | |
PCT/FR2002/003809 WO2003040142A1 (fr) | 2001-11-09 | 2002-11-07 | Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE308541T1 true ATE308541T1 (de) | 2005-11-15 |
Family
ID=26213259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02793211T ATE308541T1 (de) | 2001-11-09 | 2002-11-07 | 2-amino-4-heteroarylethyl-thiazolinderivate und ihre verwendung als hemmstoffe der induzierbaren no-synthase |
Country Status (19)
Country | Link |
---|---|
US (1) | US6872740B2 (de) |
EP (1) | EP1446402B1 (de) |
JP (1) | JP4365681B2 (de) |
AT (1) | ATE308541T1 (de) |
AU (1) | AU2002358874B2 (de) |
BR (1) | BR0206363A (de) |
CA (1) | CA2465691C (de) |
DE (1) | DE60207104T2 (de) |
DK (1) | DK1446402T3 (de) |
ES (1) | ES2250731T3 (de) |
HR (1) | HRP20040401A2 (de) |
HU (1) | HUP0402038A2 (de) |
IL (2) | IL161842A0 (de) |
MA (1) | MA27077A1 (de) |
MX (1) | MXPA04003766A (de) |
NO (1) | NO20033130L (de) |
PL (1) | PL370322A1 (de) |
RU (1) | RU2004117525A (de) |
WO (1) | WO2003040142A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04003695A (es) * | 2001-11-09 | 2004-07-30 | Aventis Pharma Sa | Derivados de 2-amino-tiazolina y su uso como inhibidores de no-sintasa inducible. |
CN101346357B (zh) | 2005-10-25 | 2014-04-02 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
EP2151435A4 (de) | 2007-04-24 | 2011-09-14 | Shionogi & Co | Pharmazeutische zusammensetzung zur behandlung von morbus alzheimer |
BRPI0811034A2 (pt) | 2007-04-24 | 2014-12-09 | Shionogi & Co | Derivados de aminodi-hidrotiazina substituídos com um grupo cíclico e seus usos e composições farmacêuticas |
CA2727859C (en) | 2008-06-13 | 2016-11-01 | Shionogi & Co., Ltd. | SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ß-SECRETASE-INHIBITING ACTIVITY |
WO2010047372A1 (ja) | 2008-10-22 | 2010-04-29 | 塩野義製薬株式会社 | Bace1阻害活性を有する2-アミノピリミジン-4-オンおよび2-アミノピリジン誘導体 |
JPWO2011071135A1 (ja) | 2009-12-11 | 2013-04-22 | 塩野義製薬株式会社 | オキサジン誘導体 |
EP2634188A4 (de) | 2010-10-29 | 2014-05-07 | Shionogi & Co | Kondensiertes aminodihydropyrimidinderivat |
JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
EP2703399A4 (de) | 2011-04-26 | 2014-10-15 | Shionogi & Co | Oxazinderivat und bace-1-hemmer damit |
JP2016501827A (ja) | 2012-10-24 | 2016-01-21 | 塩野義製薬株式会社 | Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体 |
WO2016064009A1 (ko) * | 2014-10-24 | 2016-04-28 | 한국해양과학기술원 | 라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5533094A (en) * | 1992-11-27 | 1994-06-22 | Wellcome Foundation Limited, The | Enzyme inhibitors |
EP0897912A1 (de) * | 1993-10-21 | 1999-02-24 | G.D. Searle & Co. | Amidinoderivate als NO-Synthetase-Inhibitoren |
AU4149696A (en) * | 1994-11-15 | 1996-06-06 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
FR2810037B1 (fr) * | 2000-06-09 | 2004-04-23 | Aventis Pharma Sa | Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible |
-
2002
- 2002-11-07 WO PCT/FR2002/003809 patent/WO2003040142A1/fr active IP Right Grant
- 2002-11-07 PL PL02370322A patent/PL370322A1/xx unknown
- 2002-11-07 JP JP2003542188A patent/JP4365681B2/ja not_active Expired - Fee Related
- 2002-11-07 IL IL16184202A patent/IL161842A0/xx unknown
- 2002-11-07 AT AT02793211T patent/ATE308541T1/de active
- 2002-11-07 HU HU0402038A patent/HUP0402038A2/hu unknown
- 2002-11-07 RU RU2004117525/04A patent/RU2004117525A/ru not_active Application Discontinuation
- 2002-11-07 BR BR0206363-8A patent/BR0206363A/pt not_active Application Discontinuation
- 2002-11-07 DE DE60207104T patent/DE60207104T2/de not_active Expired - Lifetime
- 2002-11-07 CA CA2465691A patent/CA2465691C/fr not_active Expired - Fee Related
- 2002-11-07 ES ES02793211T patent/ES2250731T3/es not_active Expired - Lifetime
- 2002-11-07 AU AU2002358874A patent/AU2002358874B2/en not_active Ceased
- 2002-11-07 DK DK02793211T patent/DK1446402T3/da active
- 2002-11-07 EP EP02793211A patent/EP1446402B1/de not_active Expired - Lifetime
- 2002-11-07 MX MXPA04003766A patent/MXPA04003766A/es active IP Right Grant
- 2002-11-08 US US10/291,110 patent/US6872740B2/en not_active Expired - Fee Related
-
2003
- 2003-07-08 NO NO20033130A patent/NO20033130L/no unknown
-
2004
- 2004-04-22 MA MA27645A patent/MA27077A1/fr unknown
- 2004-05-06 IL IL161842A patent/IL161842A/en not_active IP Right Cessation
- 2004-05-06 HR HR20040401A patent/HRP20040401A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE60207104T2 (de) | 2006-07-13 |
CA2465691A1 (fr) | 2003-05-15 |
HUP0402038A2 (hu) | 2005-01-28 |
RU2004117525A (ru) | 2005-04-20 |
US20030225140A1 (en) | 2003-12-04 |
IL161842A (en) | 2010-12-30 |
AU2002358874B2 (en) | 2007-09-06 |
EP1446402A1 (de) | 2004-08-18 |
MXPA04003766A (es) | 2004-07-29 |
JP2005509651A (ja) | 2005-04-14 |
DK1446402T3 (da) | 2006-03-06 |
PL370322A1 (en) | 2005-05-16 |
DE60207104D1 (de) | 2005-12-08 |
US6872740B2 (en) | 2005-03-29 |
NO20033130L (no) | 2003-08-27 |
HRP20040401A2 (en) | 2004-10-31 |
WO2003040142A1 (fr) | 2003-05-15 |
NO20033130D0 (no) | 2003-07-08 |
ES2250731T3 (es) | 2006-04-16 |
JP4365681B2 (ja) | 2009-11-18 |
MA27077A1 (fr) | 2004-12-20 |
IL161842A0 (en) | 2005-11-20 |
BR0206363A (pt) | 2003-12-23 |
EP1446402B1 (de) | 2005-11-02 |
CA2465691C (fr) | 2011-07-19 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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