DK1446402T3 - 2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase - Google Patents

2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase

Info

Publication number
DK1446402T3
DK1446402T3 DK02793211T DK02793211T DK1446402T3 DK 1446402 T3 DK1446402 T3 DK 1446402T3 DK 02793211 T DK02793211 T DK 02793211T DK 02793211 T DK02793211 T DK 02793211T DK 1446402 T3 DK1446402 T3 DK 1446402T3
Authority
DK
Denmark
Prior art keywords
synthase
inducible
inhibitors
amino
derivatives
Prior art date
Application number
DK02793211T
Other languages
Danish (da)
English (en)
Inventor
Eric Bacque
Antony Bigot
Jean-Christophe Carry
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114509A external-priority patent/FR2832151B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK1446402T3 publication Critical patent/DK1446402T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28Radicals substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02793211T 2001-11-09 2002-11-07 2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase DK1446402T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0114509A FR2832151B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297702P 2002-01-30 2002-01-30

Publications (1)

Publication Number Publication Date
DK1446402T3 true DK1446402T3 (da) 2006-03-06

Family

ID=26213259

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02793211T DK1446402T3 (da) 2001-11-09 2002-11-07 2-Amino-4-heteroarylethylthiazolinderivater og deres anvendelse som inhibitorer for inducerbar NO-synthase

Country Status (19)

Country Link
US (1) US6872740B2 (de)
EP (1) EP1446402B1 (de)
JP (1) JP4365681B2 (de)
AT (1) ATE308541T1 (de)
AU (1) AU2002358874B2 (de)
BR (1) BR0206363A (de)
CA (1) CA2465691C (de)
DE (1) DE60207104T2 (de)
DK (1) DK1446402T3 (de)
ES (1) ES2250731T3 (de)
HR (1) HRP20040401A2 (de)
HU (1) HUP0402038A2 (de)
IL (2) IL161842A0 (de)
MA (1) MA27077A1 (de)
MX (1) MXPA04003766A (de)
NO (1) NO20033130L (de)
PL (1) PL370322A1 (de)
RU (1) RU2004117525A (de)
WO (1) WO2003040142A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2669810A1 (fr) * 2001-11-09 2003-05-15 Aventis Pharma S.A. Composes intermediaires pour la preparation de derives de 2-amino-thiazoline
CN103936690B (zh) 2005-10-25 2016-06-08 盐野义制药株式会社 氨基二氢噻嗪衍生物
JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
US8168630B2 (en) 2007-04-24 2012-05-01 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives substituted with a cyclic group
MX2010013256A (es) 2008-06-13 2010-12-21 Shionogi & Co Derivado heterociclico que contiene azufre que tiene actividad inhibitoria de beta-secretasa.
CN102186841A (zh) 2008-10-22 2011-09-14 盐野义制药株式会社 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
WO2011071135A1 (ja) * 2009-12-11 2011-06-16 塩野義製薬株式会社 オキサジン誘導体
EP2634186A4 (de) 2010-10-29 2014-03-26 Shionogi & Co Naphthyridinderivat
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
TW201247635A (en) 2011-04-26 2012-12-01 Shionogi & Co Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
JP2016501827A (ja) 2012-10-24 2016-01-21 塩野義製薬株式会社 Bace1阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
WO2016064009A1 (ko) * 2014-10-24 2016-04-28 한국해양과학기술원 라말린을 함유하는 퇴행성 뇌질환의 예방 또는 치료용 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300616A (en) * 1992-11-27 1994-06-30 Wellcome Found Enzyme inhibitors
EP0724570B1 (de) * 1993-10-21 1999-03-03 G.D. Searle & Co. Amidino-derivate als no-synthetase inhibitoren
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

Also Published As

Publication number Publication date
MXPA04003766A (es) 2004-07-29
JP2005509651A (ja) 2005-04-14
NO20033130L (no) 2003-08-27
ES2250731T3 (es) 2006-04-16
IL161842A0 (en) 2005-11-20
PL370322A1 (en) 2005-05-16
US20030225140A1 (en) 2003-12-04
US6872740B2 (en) 2005-03-29
CA2465691A1 (fr) 2003-05-15
JP4365681B2 (ja) 2009-11-18
CA2465691C (fr) 2011-07-19
HUP0402038A2 (hu) 2005-01-28
BR0206363A (pt) 2003-12-23
ATE308541T1 (de) 2005-11-15
DE60207104T2 (de) 2006-07-13
MA27077A1 (fr) 2004-12-20
EP1446402A1 (de) 2004-08-18
IL161842A (en) 2010-12-30
HRP20040401A2 (en) 2004-10-31
DE60207104D1 (de) 2005-12-08
RU2004117525A (ru) 2005-04-20
NO20033130D0 (no) 2003-07-08
WO2003040142A1 (fr) 2003-05-15
AU2002358874B2 (en) 2007-09-06
EP1446402B1 (de) 2005-11-02

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