DK1401828T3 - N-Formylhydroxylaminforbindelser som inhibitorer af PDF - Google Patents

N-Formylhydroxylaminforbindelser som inhibitorer af PDF

Info

Publication number
DK1401828T3
DK1401828T3 DK02754681T DK02754681T DK1401828T3 DK 1401828 T3 DK1401828 T3 DK 1401828T3 DK 02754681 T DK02754681 T DK 02754681T DK 02754681 T DK02754681 T DK 02754681T DK 1401828 T3 DK1401828 T3 DK 1401828T3
Authority
DK
Denmark
Prior art keywords
pdf
inhibitors
formylhydroxylamine
compounds
formylhydroxylamine compounds
Prior art date
Application number
DK02754681T
Other languages
English (en)
Inventor
Dinesh V Patel
Rakesh K Jain
Alvarez Salvador Garcia
Zhengyu Yuan
Jeffrey Jacobs
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Application granted granted Critical
Publication of DK1401828T3 publication Critical patent/DK1401828T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK02754681T 2001-06-15 2002-06-14 N-Formylhydroxylaminforbindelser som inhibitorer af PDF DK1401828T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US36031302P 2002-02-27 2002-02-27

Publications (1)

Publication Number Publication Date
DK1401828T3 true DK1401828T3 (da) 2006-07-31

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02754681T DK1401828T3 (da) 2001-06-15 2002-06-14 N-Formylhydroxylaminforbindelser som inhibitorer af PDF

Country Status (31)

Country Link
US (1) US7148242B2 (da)
EP (1) EP1401828B1 (da)
JP (1) JP4361365B2 (da)
KR (2) KR20060014083A (da)
CN (1) CN1511152A (da)
AR (1) AR036053A1 (da)
AT (1) ATE323081T1 (da)
AU (1) AU2002321062B2 (da)
BR (1) BR0210377A (da)
CA (1) CA2448526A1 (da)
CO (1) CO5640131A2 (da)
CY (1) CY1105085T1 (da)
CZ (1) CZ20033388A3 (da)
DE (1) DE60210612T2 (da)
DK (1) DK1401828T3 (da)
ES (1) ES2262824T3 (da)
HK (1) HK1064370A1 (da)
HU (1) HUP0400208A3 (da)
IL (1) IL158770A0 (da)
MX (1) MXPA03011628A (da)
MY (1) MY138619A (da)
NO (1) NO327420B1 (da)
NZ (1) NZ529489A (da)
PE (1) PE20030100A1 (da)
PL (1) PL364476A1 (da)
PT (1) PT1401828E (da)
RU (1) RU2325386C2 (da)
SI (1) SI1401828T1 (da)
SK (1) SK15242003A3 (da)
WO (1) WO2002102790A1 (da)
ZA (1) ZA200308379B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60219630T2 (de) * 2001-06-15 2007-12-27 Vicuron Pharmaceuticals, Inc., Fremont Bicyclische pyrrolidinverbindungen
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
MXPA05003089A (es) * 2002-09-19 2005-05-27 Novartis Ag Proceso para preparar intermediarios.
CN1759097A (zh) 2003-02-21 2006-04-12 诺瓦提斯公司 制备用以获得n-甲酰基羟胺的中间体的化学方法
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
JP2009513485A (ja) * 2003-06-26 2009-04-02 ノバルティス アクチエンゲゼルシャフト ある種の抗菌性n−ホルミルヒドロキシルアミン化合物の製造に有用な中間体の製造法
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
RU2007103299A (ru) * 2004-06-30 2008-08-10 Новартис АГ (CH) Способ повышения чувствительности к ингибиторам пептиддеформилазы с помощью ингибиторов откачивающего насоса
WO2006055663A2 (en) 2004-11-17 2006-05-26 Smithkline Beecham Corporation The use of novel antibacterial compounds
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
US7705037B2 (en) 2005-06-07 2010-04-27 Novartis Ag 1-substituted pyrrolidin-2-ones and use thereof as peptide deformylase inhibitors
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
CA2643267A1 (en) * 2006-03-03 2007-09-20 Novartis Ag N-formyl hydroxylamine compounds
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
CA2771568A1 (en) * 2009-09-04 2011-03-10 Novartis Ag Heteroaryl compounds as kinase inhibitors
JP2013521324A (ja) 2010-03-10 2013-06-10 インゲニウム ファーマシューティカルズ ジーエムビーエイチ プロテインキナーゼの阻害剤
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
ES2876974T3 (es) 2015-04-07 2021-11-15 Novartis Ag Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
WO2017193924A1 (zh) * 2016-05-11 2017-11-16 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052511A (en) 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4311705A (en) 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4303662A (en) 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
US4321383A (en) 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
JPS6188884A (ja) 1984-10-04 1986-05-07 Sankyo Co Ltd エンケフアリナ−ゼb阻害物質およびその製法
US4599361A (en) 1985-09-10 1986-07-08 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
DK77487A (da) 1986-03-11 1987-09-12 Hoffmann La Roche Hydroxylaminderivater
FR2609289B1 (fr) 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
US5128346A (en) 1987-09-21 1992-07-07 Abbott Laboratories Derivatives of D-glutamic acid and D-aspartic acid
EP0334244A3 (en) 1988-03-25 1991-05-29 The Procter & Gamble Company Bradykinin antagonist peptides
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827308D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8919251D0 (en) 1989-08-24 1989-10-04 British Bio Technology Compounds
GB8921326D0 (en) 1989-09-21 1989-11-08 Beecham Group Plc Novel treatment
US5268384A (en) 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
DE69108363T2 (de) 1990-12-03 1995-08-31 Celltech Ltd Peptidylderivate.
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) 1991-02-07 1991-03-27 British Bio Technology Compounds
IT1245712B (it) 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
AU2228292A (en) 1991-06-14 1993-01-12 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
US5256657A (en) 1991-08-19 1993-10-26 Sterling Winthrop, Inc. Succinamide derivative matrix-metalloprotease inhibitors
JPH05125029A (ja) 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
AU661058B2 (en) 1991-11-08 1995-07-13 Sankyo Company Limited Piperazic acid derivatives as collagenase inhibitor
DE69309047T2 (de) 1992-04-07 1997-09-11 British Biotech Pharm Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren
GB9211706D0 (en) 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211707D0 (en) 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5318964A (en) 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
GB9215665D0 (en) 1992-07-23 1992-09-09 British Bio Technology Compounds
US5552419A (en) 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
CN1105799A (zh) 1993-03-18 1995-07-26 大制药株式会社 作为基质金属蛋白酶抑制剂的喹诺酮衍生物
JPH08500124A (ja) 1993-04-27 1996-01-09 セルテック セラピューティックス リミテッド メタロプロテイナーゼインヒビターとしてのペプチジル誘導体
GB9308695D0 (en) 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
GB9501737D0 (en) 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
GB9411598D0 (en) 1994-06-09 1994-08-03 Hoffmann La Roche Hydroxamic acid derivatives
GB9502858D0 (en) 1995-02-14 1995-04-05 British Biotech Pharm Novel use of matrix metalloproteinase inhibitors
GB9504084D0 (en) 1995-03-01 1995-04-19 British Biotech Pharm Synthesis of carboxylic and hydroxamic acid derivatives
FR2733750B1 (fr) 1995-05-03 1997-06-13 Synthelabo Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique
ATE305781T1 (de) 1996-02-23 2005-10-15 Lilly Co Eli Non-peptidische vasopressin via antagonisten
TW448172B (en) 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
GB9613547D0 (en) 1996-06-27 1996-08-28 Pharmacia Spa Matrix metalloproteinase inhibitors
AUPO721997A0 (en) 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
AU8858398A (en) 1997-07-10 1999-02-08 Pharmacia & Upjohn S.P.A. Matrix metalloproteinase inhibitors
CN1298299A (zh) 1998-02-07 2001-06-06 英国生物技术药物有限公司 抗菌剂

Also Published As

Publication number Publication date
HK1064370A1 (en) 2005-01-28
ATE323081T1 (de) 2006-04-15
KR20040010721A (ko) 2004-01-31
ZA200308379B (en) 2004-05-21
PT1401828E (pt) 2006-08-31
BR0210377A (pt) 2004-08-10
JP4361365B2 (ja) 2009-11-11
AU2002321062B2 (en) 2006-02-02
RU2325386C2 (ru) 2008-05-27
NZ529489A (en) 2005-10-28
US20030045479A1 (en) 2003-03-06
HUP0400208A2 (hu) 2004-06-28
NO20035571L (no) 2004-02-16
EP1401828B1 (en) 2006-04-12
AR036053A1 (es) 2004-08-04
RU2003137565A (ru) 2005-05-27
PE20030100A1 (es) 2003-03-28
US7148242B2 (en) 2006-12-12
KR20060014083A (ko) 2006-02-14
CA2448526A1 (en) 2002-12-27
IL158770A0 (en) 2004-05-12
SK15242003A3 (sk) 2004-07-07
WO2002102790A1 (en) 2002-12-27
DE60210612D1 (de) 2006-05-24
KR100589544B1 (ko) 2006-06-15
EP1401828A1 (en) 2004-03-31
JP2005502606A (ja) 2005-01-27
CO5640131A2 (es) 2006-05-31
NO20035571D0 (no) 2003-12-12
CN1511152A (zh) 2004-07-07
PL364476A1 (en) 2004-12-13
CY1105085T1 (el) 2009-11-04
MXPA03011628A (es) 2005-03-07
MY138619A (en) 2009-07-31
CZ20033388A3 (en) 2004-03-17
ES2262824T3 (es) 2006-12-01
NO327420B1 (no) 2009-06-29
HUP0400208A3 (en) 2008-10-28
SI1401828T1 (sl) 2006-10-31
DE60210612T2 (de) 2006-09-21

Similar Documents

Publication Publication Date Title
DK1401828T3 (da) N-Formylhydroxylaminforbindelser som inhibitorer af PDF
DK1463506T3 (da) Substituerede quinazolin-derivater som inhibitorer af aurora-kinaser
DK1438306T3 (da) Derivater af UK-2A
DK1562589T3 (da) Diaminotriazoler der er nyttige som inhibitorer af proteinkinaser
NO20033593D0 (no) Kinazoliner som MMP-13 inhibitorer
DK1611112T3 (da) Isoxazolforbindelser som hæmmere af varmechokproteiner
DK1532138T3 (da) Inhibitorer af tyrosinkinaser
DK1664043T3 (da) Sammensætninger egnede som inhibitorer af proteinkinaser
DK1581515T3 (da) Triazolderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1
ATE294805T1 (de) Triazoloverbindungen als mmp-inhibitoren
DK1417180T3 (da) Fremstilling af aminopyrimidinforbindelser
IS6971A (is) Ný efnasambönd
DK1542977T3 (da) 2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
NO20041887L (no) Benzomidazoler anvendelige som proteinkinase-inhibitorer
NO20033618L (no) Ftalayinon-piperidino-derivater som PDE-4-inhibitorer
IS7287A (is) Pýrimídín efnasambönd
DK1840125T3 (da) Mellemprodukter til fremstilling af dioxan-2-alkylcarbamater
DK1660090T3 (da) Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
IS6868A (is) Ný pýrimidínefnasambönd
DK1516540T3 (da) Anvendelse af vitamin D-forbindelser
DK1536796T3 (da) N-arylpiperidinsubstituerede biphenylcarboxamider som inhibitorer af apolipoprotein B-sektion
DK1600441T3 (da) Krystallinsk form af elrcanidipinhydrochlorid til anvendelse som et antihypertensivt middel
DK1892239T3 (da) Inhibitorer af cytosol-phospholipase A2
DK1353923T3 (da) Forbedret fremgangsmåde til syntese af carbapenem
DE60220914D1 (de) Aminoacetonitril-verbindungen zur bekämpfung von endoparasiten