DE60210612D1 - N-formylhydroxylamin verbindungen als inhibitoren von pdf - Google Patents
N-formylhydroxylamin verbindungen als inhibitoren von pdfInfo
- Publication number
- DE60210612D1 DE60210612D1 DE60210612T DE60210612T DE60210612D1 DE 60210612 D1 DE60210612 D1 DE 60210612D1 DE 60210612 T DE60210612 T DE 60210612T DE 60210612 T DE60210612 T DE 60210612T DE 60210612 D1 DE60210612 D1 DE 60210612D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- formylhydroxylamine
- compounds
- formylhydroxylamine compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29841901P | 2001-06-15 | 2001-06-15 | |
| US298419P | 2001-06-15 | ||
| US36031302P | 2002-02-27 | 2002-02-27 | |
| US360313P | 2002-02-27 | ||
| PCT/EP2002/006604 WO2002102790A1 (en) | 2001-06-15 | 2002-06-14 | N-formyl hydroxylamine compounds as inhibitors of pdf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60210612D1 true DE60210612D1 (de) | 2006-05-24 |
| DE60210612T2 DE60210612T2 (de) | 2006-09-21 |
Family
ID=26970649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60210612T Expired - Lifetime DE60210612T2 (de) | 2001-06-15 | 2002-06-14 | N-formylhydroxylamin verbindungen als inhibitoren von pdf |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7148242B2 (de) |
| EP (1) | EP1401828B1 (de) |
| JP (1) | JP4361365B2 (de) |
| KR (2) | KR20060014083A (de) |
| CN (1) | CN1511152A (de) |
| AR (1) | AR036053A1 (de) |
| AT (1) | ATE323081T1 (de) |
| AU (1) | AU2002321062B2 (de) |
| BR (1) | BR0210377A (de) |
| CA (1) | CA2448526A1 (de) |
| CO (1) | CO5640131A2 (de) |
| CY (1) | CY1105085T1 (de) |
| CZ (1) | CZ20033388A3 (de) |
| DE (1) | DE60210612T2 (de) |
| DK (1) | DK1401828T3 (de) |
| ES (1) | ES2262824T3 (de) |
| HK (1) | HK1064370A1 (de) |
| HU (1) | HUP0400208A3 (de) |
| IL (1) | IL158770A0 (de) |
| MX (1) | MXPA03011628A (de) |
| MY (1) | MY138619A (de) |
| NO (1) | NO327420B1 (de) |
| NZ (1) | NZ529489A (de) |
| PE (1) | PE20030100A1 (de) |
| PL (1) | PL364476A1 (de) |
| PT (1) | PT1401828E (de) |
| RU (1) | RU2325386C2 (de) |
| SI (1) | SI1401828T1 (de) |
| SK (1) | SK15242003A3 (de) |
| WO (1) | WO2002102790A1 (de) |
| ZA (1) | ZA200308379B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60219630T2 (de) * | 2001-06-15 | 2007-12-27 | Vicuron Pharmaceuticals, Inc., Fremont | Bicyclische pyrrolidinverbindungen |
| GB0208579D0 (en) * | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
| WO2004026824A1 (en) | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| AU2004216178B2 (en) * | 2003-02-21 | 2008-07-03 | Novartis Ag | Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds |
| TW200427458A (en) * | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| US20070060753A1 (en) * | 2003-06-26 | 2007-03-15 | Joel Slade | Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines |
| KR100527624B1 (ko) * | 2003-08-21 | 2005-11-22 | 한기종 | 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법 |
| WO2006002896A1 (en) * | 2004-06-30 | 2006-01-12 | Novartis Ag | Method for increasing the susceptibility of peptide deformylase inhibitors by using efflux pump inhibitors |
| US20080161249A1 (en) * | 2004-11-17 | 2008-07-03 | Smithkline Beecham Corporation | Use of Novel Antibacterial Compounds |
| GT200600196A (es) | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| MX2007015421A (es) | 2005-06-07 | 2008-02-21 | Novartis Ag | Inhibidores de desformilasa peptidica (pdf) 4. |
| DE102005026231A1 (de) * | 2005-06-07 | 2006-12-14 | Origenis Ag | Peptid-Deformylase (PDF) Inhibitoren 3 |
| SG133452A1 (en) * | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
| MX2008011128A (es) * | 2006-03-03 | 2008-09-08 | Novartis Ag | Compuestos de n-formil-hidroxilamina. |
| CN101328155B (zh) * | 2007-06-20 | 2010-11-03 | 上海医药工业研究院 | 噁唑烷衍生物及其制备方法和应用 |
| CN101434570B (zh) * | 2007-11-16 | 2011-02-02 | 上海医药工业研究院 | 吡咯烷衍生物及其制备方法和应用 |
| CN101584694B (zh) * | 2009-06-15 | 2011-01-12 | 华东师范大学 | 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法 |
| EP2473502A1 (de) * | 2009-09-04 | 2012-07-11 | Novartis AG | Heteroarylverbindungen als kinasehemmer |
| NZ627520A (en) | 2010-03-10 | 2015-10-30 | Astrazeneca Ab | 4-phenyl pyridine analogues as protein kinase inhibitors |
| JP5825086B2 (ja) | 2011-12-19 | 2015-12-02 | 住友化学株式会社 | α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素 |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
| EP3280795B1 (de) | 2015-04-07 | 2021-03-24 | Novartis AG | Kombination von chimärer antigen rezeptor therapie und amino pyrimidin derivaten |
| US10738028B2 (en) * | 2016-05-11 | 2020-08-11 | Rudong Ruien Pharmaceutical Technology Co. Ltd | Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4321383A (en) * | 1980-11-24 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Heterobicyclo intermediates |
| US4303662A (en) * | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
| JPS6188884A (ja) * | 1984-10-04 | 1986-05-07 | Sankyo Co Ltd | エンケフアリナ−ゼｂ阻害物質およびその製法 |
| US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US5128346A (en) * | 1987-09-21 | 1992-07-07 | Abbott Laboratories | Derivatives of D-glutamic acid and D-aspartic acid |
| EP0334244A3 (de) | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Peptide-Antagonisten von Bradykinin |
| GB8827308D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8919251D0 (en) | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB8921326D0 (en) | 1989-09-21 | 1989-11-08 | Beecham Group Plc | Novel treatment |
| US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| DK0489579T3 (da) | 1990-12-03 | 1995-06-12 | Celltech Therapeutics Ltd | Peptidylderivater |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| IT1245712B (it) * | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| WO1992022523A2 (en) | 1991-06-14 | 1992-12-23 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
| US5256657A (en) * | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
| JPH05125029A (ja) | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| WO1993009097A1 (en) | 1991-11-08 | 1993-05-13 | Sankyo Company, Limited | Collagenase inhibitor |
| WO1993020047A1 (en) | 1992-04-07 | 1993-10-14 | British Bio-Technology Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
| GB9211707D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| GB9211706D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| CA2136108A1 (en) | 1993-03-18 | 1994-09-29 | Makoto Sakamoto | Carbostyril derivatives as matrix metalloproteinases inhibitors |
| US5714491A (en) | 1993-04-27 | 1998-02-03 | Celltech Therapeutics Limited | Peptidyl derivatives as metalloproteinase inhibitors |
| GB9308695D0 (en) | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9411598D0 (en) | 1994-06-09 | 1994-08-03 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9502858D0 (en) | 1995-02-14 | 1995-04-05 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| GB9504084D0 (en) | 1995-03-01 | 1995-04-19 | British Biotech Pharm | Synthesis of carboxylic and hydroxamic acid derivatives |
| FR2733750B1 (fr) | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| DK0939632T3 (da) | 1996-02-23 | 2006-01-30 | Lilly Co Eli | Non-peptidyl vasopressin V1a antagonister |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| GB9613547D0 (en) | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
| AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| EP0925289A1 (de) | 1997-07-10 | 1999-06-30 | PHARMACIA & UPJOHN S.p.A. | Matrix metalloproteinase inhibitoren |
| ES2221359T3 (es) | 1998-02-07 | 2004-12-16 | Vernalis (Oxford) Ltd | Agentes antibacterianos. |
-
2002
- 2002-06-13 AR ARP020102229A patent/AR036053A1/es not_active Application Discontinuation
- 2002-06-14 NZ NZ529489A patent/NZ529489A/en unknown
- 2002-06-14 SK SK1524-2003A patent/SK15242003A3/sk not_active Application Discontinuation
- 2002-06-14 CN CNA028105966A patent/CN1511152A/zh active Pending
- 2002-06-14 PE PE2002000516A patent/PE20030100A1/es not_active Application Discontinuation
- 2002-06-14 AT AT02754681T patent/ATE323081T1/de not_active IP Right Cessation
- 2002-06-14 PL PL02364476A patent/PL364476A1/xx not_active Application Discontinuation
- 2002-06-14 BR BR0210377-0A patent/BR0210377A/pt not_active IP Right Cessation
- 2002-06-14 KR KR1020067002113A patent/KR20060014083A/ko not_active Application Discontinuation
- 2002-06-14 WO PCT/EP2002/006604 patent/WO2002102790A1/en active IP Right Grant
- 2002-06-14 EP EP02754681A patent/EP1401828B1/de not_active Expired - Lifetime
- 2002-06-14 JP JP2003506263A patent/JP4361365B2/ja not_active Expired - Fee Related
- 2002-06-14 MY MYPI20022243A patent/MY138619A/en unknown
- 2002-06-14 KR KR1020037016435A patent/KR100589544B1/ko not_active IP Right Cessation
- 2002-06-14 DE DE60210612T patent/DE60210612T2/de not_active Expired - Lifetime
- 2002-06-14 CA CA002448526A patent/CA2448526A1/en not_active Abandoned
- 2002-06-14 ES ES02754681T patent/ES2262824T3/es not_active Expired - Lifetime
- 2002-06-14 AU AU2002321062A patent/AU2002321062B2/en not_active Ceased
- 2002-06-14 MX MXPA03011628A patent/MXPA03011628A/es active IP Right Grant
- 2002-06-14 PT PT02754681T patent/PT1401828E/pt unknown
- 2002-06-14 HU HU0400208A patent/HUP0400208A3/hu unknown
- 2002-06-14 US US10/171,706 patent/US7148242B2/en not_active Expired - Fee Related
- 2002-06-14 CZ CZ20033388A patent/CZ20033388A3/cs unknown
- 2002-06-14 SI SI200230358T patent/SI1401828T1/sl unknown
- 2002-06-14 IL IL15877002A patent/IL158770A0/xx unknown
- 2002-06-14 DK DK02754681T patent/DK1401828T3/da active
- 2002-06-14 RU RU2003137565/04A patent/RU2325386C2/ru not_active IP Right Cessation
-
2003
- 2003-10-28 ZA ZA200308379A patent/ZA200308379B/en unknown
- 2003-12-03 CO CO03106413A patent/CO5640131A2/es not_active Application Discontinuation
- 2003-12-12 NO NO20035571A patent/NO327420B1/no not_active IP Right Cessation
-
2004
- 2004-09-14 HK HK04107013A patent/HK1064370A1/xx not_active IP Right Cessation
-
2006
- 2006-07-12 CY CY20061100965T patent/CY1105085T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
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| R082 | Change of representative |
Ref document number: 1401828 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |