BR0210377A - Compostos de n-formil hidroxil amina - Google Patents

Compostos de n-formil hidroxil amina

Info

Publication number
BR0210377A
BR0210377A BR0210377-0A BR0210377A BR0210377A BR 0210377 A BR0210377 A BR 0210377A BR 0210377 A BR0210377 A BR 0210377A BR 0210377 A BR0210377 A BR 0210377A
Authority
BR
Brazil
Prior art keywords
amine compounds
hydroxyl amine
formyl
alkanes
treatment
Prior art date
Application number
BR0210377-0A
Other languages
English (en)
Inventor
Dinesh V Patel
Zhengyu Yuan
Rakesh K Jain
Salvador Garcia Alvarez
Jeffrey Jacobs
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of BR0210377A publication Critical patent/BR0210377A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"COMPOSTOS DE N-FORMIL HIDROXIL AMINA". N-[1-oxo-2-alquil-3-(N-hidróxi-formamido)propil] (carbonil amino-aril ou -heteroaril)azaciclo~ 4-7~ alcanos, ou tiazaciclo~ 4-7~ alcanos, ou imidazaciclo ~ 4-7~ alcanos, têm propriedades interessantes, por exemplo, no tratamento ou prevenção de desordens suscetíveis a tratamento por inibidores de peptidil deformilase, tal como o tratamento de infecções bacterianas.
BR0210377-0A 2001-06-15 2002-06-14 Compostos de n-formil hidroxil amina BR0210377A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US36031302P 2002-02-27 2002-02-27
PCT/EP2002/006604 WO2002102790A1 (en) 2001-06-15 2002-06-14 N-formyl hydroxylamine compounds as inhibitors of pdf

Publications (1)

Publication Number Publication Date
BR0210377A true BR0210377A (pt) 2004-08-10

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210377-0A BR0210377A (pt) 2001-06-15 2002-06-14 Compostos de n-formil hidroxil amina

Country Status (31)

Country Link
US (1) US7148242B2 (pt)
EP (1) EP1401828B1 (pt)
JP (1) JP4361365B2 (pt)
KR (2) KR20060014083A (pt)
CN (1) CN1511152A (pt)
AR (1) AR036053A1 (pt)
AT (1) ATE323081T1 (pt)
AU (1) AU2002321062B2 (pt)
BR (1) BR0210377A (pt)
CA (1) CA2448526A1 (pt)
CO (1) CO5640131A2 (pt)
CY (1) CY1105085T1 (pt)
CZ (1) CZ20033388A3 (pt)
DE (1) DE60210612T2 (pt)
DK (1) DK1401828T3 (pt)
ES (1) ES2262824T3 (pt)
HK (1) HK1064370A1 (pt)
HU (1) HUP0400208A3 (pt)
IL (1) IL158770A0 (pt)
MX (1) MXPA03011628A (pt)
MY (1) MY138619A (pt)
NO (1) NO327420B1 (pt)
NZ (1) NZ529489A (pt)
PE (1) PE20030100A1 (pt)
PL (1) PL364476A1 (pt)
PT (1) PT1401828E (pt)
RU (1) RU2325386C2 (pt)
SI (1) SI1401828T1 (pt)
SK (1) SK15242003A3 (pt)
WO (1) WO2002102790A1 (pt)
ZA (1) ZA200308379B (pt)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
ES2283589T3 (es) * 2001-06-15 2007-11-01 Vicuron Pharmaceuticals, Inc. Compuestos biciclicos de pirrolidina.
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
PL374961A1 (en) * 2002-09-19 2005-11-14 Novartis Ag Process for preparing intermediates
WO2004076053A2 (en) * 2003-02-21 2004-09-10 Novartis Ag Chemical process for the preparation of intermediates to obtain n-formyl hydroxylamine compounds
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
US20070060753A1 (en) * 2003-06-26 2007-03-15 Joel Slade Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
CN1976703A (zh) * 2004-06-30 2007-06-06 诺瓦提斯公司 通过使用外排泵抑制剂增加肽脱甲酰基酶抑制剂敏感性的方法
JP2008520686A (ja) 2004-11-17 2008-06-19 スミスクライン・ビーチャム・コーポレイション 新規な抗菌化合物の使用
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
CN101184728B (zh) * 2005-06-07 2011-08-17 诺瓦提斯公司 肽脱甲酰基酶（pdf）抑制剂4
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
CN101395148A (zh) * 2006-03-03 2009-03-25 诺瓦提斯公司 N-甲酰基羟胺化合物
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
CN102498107A (zh) * 2009-09-04 2012-06-13 诺瓦提斯公司 作为激酶抑制剂的杂芳基化合物
US8518948B2 (en) 2010-03-10 2013-08-27 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
ES2876974T3 (es) 2015-04-07 2021-11-15 Novartis Ag Combinación de terapia con receptor de antígeno quimérico y derivados de amino pirimidina
WO2017193924A1 (zh) * 2016-05-11 2017-11-16 如东瑞恩医药科技有限公司 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用

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Also Published As

Publication number Publication date
KR20040010721A (ko) 2004-01-31
CA2448526A1 (en) 2002-12-27
JP4361365B2 (ja) 2009-11-11
MXPA03011628A (es) 2005-03-07
MY138619A (en) 2009-07-31
EP1401828A1 (en) 2004-03-31
WO2002102790A1 (en) 2002-12-27
NZ529489A (en) 2005-10-28
CY1105085T1 (el) 2009-11-04
RU2325386C2 (ru) 2008-05-27
NO327420B1 (no) 2009-06-29
AR036053A1 (es) 2004-08-04
CZ20033388A3 (en) 2004-03-17
SI1401828T1 (sl) 2006-10-31
AU2002321062B2 (en) 2006-02-02
HUP0400208A3 (en) 2008-10-28
PE20030100A1 (es) 2003-03-28
NO20035571D0 (no) 2003-12-12
DE60210612T2 (de) 2006-09-21
PL364476A1 (en) 2004-12-13
ZA200308379B (en) 2004-05-21
KR100589544B1 (ko) 2006-06-15
CN1511152A (zh) 2004-07-07
RU2003137565A (ru) 2005-05-27
ATE323081T1 (de) 2006-04-15
NO20035571L (no) 2004-02-16
KR20060014083A (ko) 2006-02-14
CO5640131A2 (es) 2006-05-31
US7148242B2 (en) 2006-12-12
ES2262824T3 (es) 2006-12-01
IL158770A0 (en) 2004-05-12
SK15242003A3 (sk) 2004-07-07
EP1401828B1 (en) 2006-04-12
HUP0400208A2 (hu) 2004-06-28
PT1401828E (pt) 2006-08-31
DK1401828T3 (da) 2006-07-31
US20030045479A1 (en) 2003-03-06
JP2005502606A (ja) 2005-01-27
HK1064370A1 (en) 2005-01-28
DE60210612D1 (de) 2006-05-24

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.