ATE360014T1 - Bicyclische pyrrolidinverbindungen - Google Patents
Bicyclische pyrrolidinverbindungenInfo
- Publication number
- ATE360014T1 ATE360014T1 AT02762286T AT02762286T ATE360014T1 AT E360014 T1 ATE360014 T1 AT E360014T1 AT 02762286 T AT02762286 T AT 02762286T AT 02762286 T AT02762286 T AT 02762286T AT E360014 T1 ATE360014 T1 AT E360014T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- pyrrolidine compounds
- 7alkanes
- bicyclic pyrrolidine
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29841801P | 2001-06-15 | 2001-06-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360014T1 true ATE360014T1 (de) | 2007-05-15 |
Family
ID=23150431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02762286T ATE360014T1 (de) | 2001-06-15 | 2002-06-14 | Bicyclische pyrrolidinverbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6987104B2 (de) |
| EP (1) | EP1406893B1 (de) |
| JP (1) | JP4314340B2 (de) |
| CN (1) | CN1512991A (de) |
| AT (1) | ATE360014T1 (de) |
| BR (1) | BR0210422A (de) |
| CA (1) | CA2446931A1 (de) |
| CY (1) | CY1107688T1 (de) |
| DE (1) | DE60219630T2 (de) |
| DK (1) | DK1406893T3 (de) |
| ES (1) | ES2283589T3 (de) |
| PT (1) | PT1406893E (de) |
| WO (1) | WO2002102791A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1406893T3 (da) * | 2001-06-15 | 2007-08-06 | Vicuron Pharm Inc | Bicykliske pyrrolidinforbindelser |
| WO2004026824A1 (en) * | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| PL379008A1 (pl) * | 2003-02-21 | 2006-06-26 | Novartis Ag | Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych |
| EP1660471B1 (de) * | 2003-08-23 | 2011-05-04 | Vernalis (R&D) Limited | Derivate von hydroxamsäure als metalloproteinaseinhibitoren |
| GB0319917D0 (en) * | 2003-08-23 | 2003-09-24 | British Biotech Pharm | Metalloproteinase inhibitors |
| EP1732907A1 (de) * | 2004-03-26 | 2006-12-20 | Arpida A/S | Peptid-deformylase-hemmer |
| PE20060426A1 (es) | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| EP1827449A4 (de) * | 2004-11-17 | 2008-01-23 | Smithkline Beecham Corp | Verwendung von neuen antibakteriellen verbindungen |
| GT200600196A (es) * | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| CA2632921A1 (en) | 2005-12-01 | 2007-06-07 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| SG133452A1 (en) * | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
| US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
| US9085566B2 (en) * | 2007-02-02 | 2015-07-21 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and related disorders |
| AU2009279949A1 (en) * | 2008-08-04 | 2010-02-11 | Merck Sharp & Dohme Corp. | Urea derivatives as antibacterial agents |
| WO2017193924A1 (zh) * | 2016-05-11 | 2017-11-16 | 如东瑞恩医药科技有限公司 | 螺三元环、螺五元环类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤中的应用 |
| WO2018015280A1 (en) * | 2016-07-21 | 2018-01-25 | Unilever Plc | 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one for use in the treatment of gram negative bacterial infections |
| CN117224534A (zh) | 2016-07-21 | 2023-12-15 | 联合利华知识产权控股有限公司 | 用于治疗皮肤损伤的内酰胺 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052511A (en) | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
| US4290952A (en) * | 1980-06-23 | 1981-09-22 | American Home Products Corporation | Aryl-1-mercaptoalkanoylproline and homoproline derivatives |
| US4311705A (en) | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4321383A (en) | 1980-11-24 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Heterobicyclo intermediates |
| US4303662A (en) | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
| JPS6188884A (ja) | 1984-10-04 | 1986-05-07 | Sankyo Co Ltd | エンケフアリナ−ゼｂ阻害物質およびその製法 |
| US4599361A (en) | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US5128346A (en) | 1987-09-21 | 1992-07-07 | Abbott Laboratories | Derivatives of D-glutamic acid and D-aspartic acid |
| EP0334244A3 (de) | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Peptide-Antagonisten von Bradykinin |
| GB8827308D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8919251D0 (en) | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB8921326D0 (en) | 1989-09-21 | 1989-11-08 | Beecham Group Plc | Novel treatment |
| US5268384A (en) | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| KR927003521A (ko) | 1990-12-03 | 1992-12-18 | 죤 에드워드 베리만 | 펩티딜(peptidyl) 유도체 |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| WO1992022523A2 (en) | 1991-06-14 | 1992-12-23 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
| US5256657A (en) | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
| JPH05125029A (ja) | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| ES2145014T3 (es) | 1991-11-08 | 2000-07-01 | Sankyo Co | Derivados de piperazina como inhibidores de la colagenasa. |
| EP0634998B1 (de) | 1992-04-07 | 1997-03-19 | British Biotech Pharmaceuticals Limited | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
| GB9211706D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| GB9211707D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| US5318964A (en) | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| AU672888B2 (en) | 1993-03-18 | 1996-10-17 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as matrix metalloproteinases inhibitors |
| GB9308695D0 (en) | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| DE69419473T2 (de) | 1993-04-27 | 2000-03-16 | Celltech Therapeutics Ltd | Peptidylderivate als inhibitoren von metalloproteinase |
| GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9411598D0 (en) | 1994-06-09 | 1994-08-03 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9502858D0 (en) | 1995-02-14 | 1995-04-05 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| GB9504084D0 (en) | 1995-03-01 | 1995-04-19 | British Biotech Pharm | Synthesis of carboxylic and hydroxamic acid derivatives |
| US5876727A (en) * | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| FR2733750B1 (fr) | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| DK0939632T3 (da) | 1996-02-23 | 2006-01-30 | Lilly Co Eli | Non-peptidyl vasopressin V1a antagonister |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| GB9613547D0 (en) | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
| AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| JP2001500533A (ja) | 1997-07-10 | 2001-01-16 | フアルマシア・エ・アツプジヨン・エツセ・ピー・アー | マトリックスメタロプロテイナーゼ・インヒビター |
| PL194240B1 (pl) | 1998-02-07 | 2007-05-31 | British Biotech Pharm | Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy |
| US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| JP2003534239A (ja) * | 1999-12-17 | 2003-11-18 | ヴァージコア・インコーポレーテッド | 新規なスクシナート化合物、組成物、並びに使用及び調製方法 |
| US6852752B2 (en) * | 1999-12-17 | 2005-02-08 | Vicuron Pharmaceuticals Inc. | Urea compounds, compositions and methods of use and preparation |
| WO2002028829A2 (en) | 2000-09-25 | 2002-04-11 | Questcor Pharmaceuticals, Inc. | Peptide deformylase inhibitors |
| AR036053A1 (es) * | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| DK1406893T3 (da) * | 2001-06-15 | 2007-08-06 | Vicuron Pharm Inc | Bicykliske pyrrolidinforbindelser |
| WO2004026824A1 (en) | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
| PL379008A1 (pl) | 2003-02-21 | 2006-06-26 | Novartis Ag | Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych |
| TW200427458A (en) | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| BRPI0411921A (pt) | 2003-06-26 | 2006-08-15 | Novartis Ag | processo para preparar intermediários úteis para preparar determinadas hidroxilaminas de n-formila antibacterianas |
| GT200600196A (es) | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina |
-
2002
- 2002-06-14 DK DK02762286T patent/DK1406893T3/da active
- 2002-06-14 ES ES02762286T patent/ES2283589T3/es not_active Expired - Lifetime
- 2002-06-14 PT PT02762286T patent/PT1406893E/pt unknown
- 2002-06-14 CN CNA028109902A patent/CN1512991A/zh active Pending
- 2002-06-14 US US10/171,705 patent/US6987104B2/en not_active Expired - Fee Related
- 2002-06-14 EP EP02762286A patent/EP1406893B1/de not_active Expired - Lifetime
- 2002-06-14 CA CA002446931A patent/CA2446931A1/en not_active Abandoned
- 2002-06-14 BR BR0210422-9A patent/BR0210422A/pt not_active IP Right Cessation
- 2002-06-14 DE DE60219630T patent/DE60219630T2/de not_active Expired - Lifetime
- 2002-06-14 AT AT02762286T patent/ATE360014T1/de not_active IP Right Cessation
- 2002-06-14 WO PCT/EP2002/006586 patent/WO2002102791A1/en active IP Right Grant
- 2002-06-14 JP JP2003506264A patent/JP4314340B2/ja not_active Expired - Fee Related
-
2005
- 2005-06-13 US US11/151,131 patent/US7612059B2/en not_active Expired - Fee Related
-
2007
- 2007-06-28 CY CY20071100856T patent/CY1107688T1/el unknown
-
2008
- 2008-12-03 US US12/327,245 patent/US20090149509A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60219630D1 (de) | 2007-05-31 |
| WO2002102791A1 (en) | 2002-12-27 |
| JP2005501020A (ja) | 2005-01-13 |
| ES2283589T3 (es) | 2007-11-01 |
| CY1107688T1 (el) | 2013-04-18 |
| EP1406893B1 (de) | 2007-04-18 |
| CA2446931A1 (en) | 2002-12-27 |
| US6987104B2 (en) | 2006-01-17 |
| BR0210422A (pt) | 2004-08-17 |
| PT1406893E (pt) | 2007-07-12 |
| EP1406893A1 (de) | 2004-04-14 |
| DE60219630T2 (de) | 2007-12-27 |
| US7612059B2 (en) | 2009-11-03 |
| US20090149509A1 (en) | 2009-06-11 |
| DK1406893T3 (da) | 2007-08-06 |
| JP4314340B2 (ja) | 2009-08-12 |
| US20050277683A1 (en) | 2005-12-15 |
| CN1512991A (zh) | 2004-07-14 |
| US20030069223A1 (en) | 2003-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1107688T1 (el) | Δικυκλικες ενωσεις πυρρολιδινης | |
| CY1116754T1 (el) | Παραγωγα νιτροκατεχολης ως αναστολεις της comt | |
| CY1105085T1 (el) | Ενωσεις τυπου ν-φορμυλο υδροξυλαμινης ως αναστολεις της pdf | |
| SE0202241D0 (sv) | Novel Compounds | |
| ATE461923T1 (de) | Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren | |
| ATE408601T1 (de) | Fredericamycin-derivate | |
| BR0316350A (pt) | Diaminotriazóis úteis como inibidores de proteìna cinases | |
| ME00572A (en) | Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto | |
| NO20073783L (no) | Pyrrolidininhibitorer for IAP | |
| BR0116804A (pt) | Derivados fenìlicos | |
| NO20056161L (no) | Formuleringer for behandling av artrittilstander | |
| NO20064325L (no) | Heteroarylaminopyrazolderivativer nyttige for behandling av diabetes | |
| DE60334536D1 (de) | Furylverbindungen | |
| BR0313634A (pt) | Derivados de benzimidazol | |
| ECSP055844A (es) | Nuevos compuestos triciclicos | |
| NO20055741D0 (no) | Nye kjemiske forbindelser | |
| NO20054361D0 (no) | Benzensylfonamidderivater, fremgangsmate for fremstilling og anvendelse derav for behandlig av smerte | |
| DE60333746D1 (de) | Thienylverbindungen | |
| CY1110537T1 (el) | Ενωσεις και μεθοδοι για την αγωγη της δυσλιπιδαιμιας | |
| BR0316723A (pt) | Derivados de anilinopirazol úteis para o tratamento de diabetes | |
| PE20030061A1 (es) | 1-biaril-1,8-naftiridin-4-ona como inhibidores de fosfodiesterasa-4 | |
| CY1111432T1 (el) | Τετραϋδροκινολινες για χρηση ως διαμορφωτες της μιτοτικης κινητικης πρωτεϊνης eg5 | |
| DK1362045T3 (da) | 2-Thio-substituerede imidazolderivater og deres anvendelse inden for farmacien | |
| EA200701813A1 (ru) | Новые амидозамещенные 6-фенилфенантридины | |
| WO2005080549A3 (de) | Trioxacarcine und deren verwendung gegen infektionskrankheiten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1406893 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |