DE60219630D1 - Bicyclische pyrrolidinverbindungen - Google Patents
Bicyclische pyrrolidinverbindungenInfo
- Publication number
- DE60219630D1 DE60219630D1 DE60219630T DE60219630T DE60219630D1 DE 60219630 D1 DE60219630 D1 DE 60219630D1 DE 60219630 T DE60219630 T DE 60219630T DE 60219630 T DE60219630 T DE 60219630T DE 60219630 D1 DE60219630 D1 DE 60219630D1
- Authority
- DE
- Germany
- Prior art keywords
- bicyclic
- treatment
- 7alkanes
- pyrrolidin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29841801P | 2001-06-15 | 2001-06-15 | |
| US298418P | 2001-06-15 | ||
| PCT/EP2002/006586 WO2002102791A1 (en) | 2001-06-15 | 2002-06-14 | Pyrrolidine bicyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60219630D1 true DE60219630D1 (de) | 2007-05-31 |
| DE60219630T2 DE60219630T2 (de) | 2007-12-27 |
Family
ID=23150431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60219630T Expired - Lifetime DE60219630T2 (de) | 2001-06-15 | 2002-06-14 | Bicyclische pyrrolidinverbindungen |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6987104B2 (de) |
| EP (1) | EP1406893B1 (de) |
| JP (1) | JP4314340B2 (de) |
| CN (1) | CN1512991A (de) |
| AT (1) | ATE360014T1 (de) |
| BR (1) | BR0210422A (de) |
| CA (1) | CA2446931A1 (de) |
| CY (1) | CY1107688T1 (de) |
| DE (1) | DE60219630T2 (de) |
| DK (1) | DK1406893T3 (de) |
| ES (1) | ES2283589T3 (de) |
| PT (1) | PT1406893E (de) |
| WO (1) | WO2002102791A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102791A1 (en) * | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
| EP1542968B1 (de) * | 2002-09-19 | 2008-12-17 | Novartis AG | Verfahren zur herstellung von zwischenprodukten |
| AU2004216178B2 (en) * | 2003-02-21 | 2008-07-03 | Novartis Ag | Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds |
| GB0319917D0 (en) * | 2003-08-23 | 2003-09-24 | British Biotech Pharm | Metalloproteinase inhibitors |
| DK1660471T3 (da) | 2003-08-23 | 2011-08-08 | Vernalis R&D Ltd | Derivater af hydroxamsyre som metalloproteinaseinhibitorer |
| WO2005092872A1 (en) * | 2004-03-26 | 2005-10-06 | Arpida A/S | Peptide deformylase inhibitors |
| PE20060426A1 (es) | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| EP1827449A4 (de) * | 2004-11-17 | 2008-01-23 | Smithkline Beecham Corp | Verwendung von neuen antibakteriellen verbindungen |
| GT200600196A (es) * | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| US7553864B2 (en) | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| SG133452A1 (en) * | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
| US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
| US9085566B2 (en) * | 2007-02-02 | 2015-07-21 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and related disorders |
| US20110212080A1 (en) * | 2008-08-04 | 2011-09-01 | Umar Faruk Mansoor | Urea derivatives as antibacterial agents |
| ES2930814T3 (es) | 2016-05-11 | 2022-12-22 | Guangdong Hebo Pharmaceutical Co Ltd | Inhibidor de péptido deformilasa de anillo espiro de tres miembros o anillo espiro de cinco miembros y uso del mismo como agente antitumoral |
| US11160787B2 (en) | 2016-07-21 | 2021-11-02 | Conopco, Inc. | 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one for use in the treatment of gram negative bacterial infections |
| CN109475527A (zh) | 2016-07-21 | 2019-03-15 | 荷兰联合利华有限公司 | 用于治疗皮肤损伤的内酰胺 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052511A (en) | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
| US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
| US4290952A (en) * | 1980-06-23 | 1981-09-22 | American Home Products Corporation | Aryl-1-mercaptoalkanoylproline and homoproline derivatives |
| US4311705A (en) | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4321383A (en) | 1980-11-24 | 1982-03-23 | E. R. Squibb & Sons, Inc. | Heterobicyclo intermediates |
| US4303662A (en) | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
| JPS6188884A (ja) | 1984-10-04 | 1986-05-07 | Sankyo Co Ltd | エンケフアリナ−ゼｂ阻害物質およびその製法 |
| US4599361A (en) | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| DK77487A (da) | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| US5128346A (en) | 1987-09-21 | 1992-07-07 | Abbott Laboratories | Derivatives of D-glutamic acid and D-aspartic acid |
| EP0334244A3 (de) | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Peptide-Antagonisten von Bradykinin |
| GB8827308D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB8919251D0 (en) | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
| GB8921326D0 (en) | 1989-09-21 | 1989-11-08 | Beecham Group Plc | Novel treatment |
| US5268384A (en) | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
| CA2073513A1 (en) | 1990-12-03 | 1992-06-04 | John Robert Porter | Peptidyl derivatives |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| WO1992022523A2 (en) | 1991-06-14 | 1992-12-23 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
| US5256657A (en) | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
| JPH05125029A (ja) | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
| AU661058B2 (en) | 1991-11-08 | 1995-07-13 | Sankyo Company Limited | Piperazic acid derivatives as collagenase inhibitor |
| ATE150452T1 (de) | 1992-04-07 | 1997-04-15 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
| GB9211707D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| GB9211706D0 (en) | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
| US5318964A (en) | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| WO1994021612A1 (en) | 1993-03-18 | 1994-09-29 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives as matrix metalloproteinases inhibitors |
| GB9308695D0 (en) | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| DE69419473T2 (de) | 1993-04-27 | 2000-03-16 | Celltech Therapeutics Ltd | Peptidylderivate als inhibitoren von metalloproteinase |
| GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9411598D0 (en) | 1994-06-09 | 1994-08-03 | Hoffmann La Roche | Hydroxamic acid derivatives |
| GB9502858D0 (en) | 1995-02-14 | 1995-04-05 | British Biotech Pharm | Novel use of matrix metalloproteinase inhibitors |
| GB9504084D0 (en) | 1995-03-01 | 1995-04-19 | British Biotech Pharm | Synthesis of carboxylic and hydroxamic acid derivatives |
| US5876727A (en) * | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| FR2733750B1 (fr) | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
| DE69734321T2 (de) | 1996-02-23 | 2006-08-10 | Eli Lilly And Co., Indianapolis | Non-peptidische vasopressin via antagonisten |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| GB9613547D0 (en) | 1996-06-27 | 1996-08-28 | Pharmacia Spa | Matrix metalloproteinase inhibitors |
| AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| CA2265671A1 (en) | 1997-07-10 | 1999-01-21 | Daniela Jabes | Matrix metalloproteinase inhibitors |
| BR9907689A (pt) | 1998-02-07 | 2000-11-14 | British Biotech Pharm | Agentes antibacterianos |
| US6797820B2 (en) | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| US6852752B2 (en) | 1999-12-17 | 2005-02-08 | Vicuron Pharmaceuticals Inc. | Urea compounds, compositions and methods of use and preparation |
| AU2268301A (en) * | 1999-12-17 | 2001-06-25 | Versicor Inc | Novel urea compounds, compositions and methods of use and preparation |
| WO2002028829A2 (en) | 2000-09-25 | 2002-04-11 | Questcor Pharmaceuticals, Inc. | Peptide deformylase inhibitors |
| WO2002102791A1 (en) | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
| AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| EP1542968B1 (de) | 2002-09-19 | 2008-12-17 | Novartis AG | Verfahren zur herstellung von zwischenprodukten |
| AU2004216178B2 (en) | 2003-02-21 | 2008-07-03 | Novartis Ag | Chemical process for the preparation of intermediates to obtain N-formyl hydroxylamine compounds |
| TW200427458A (en) | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| CN100410251C (zh) | 2003-06-26 | 2008-08-13 | 诺瓦提斯公司 | 可用于制备某些抗菌n-甲酰基羟胺的中间体的制备方法 |
| GT200600196A (es) | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina |
-
2002
- 2002-06-14 WO PCT/EP2002/006586 patent/WO2002102791A1/en active IP Right Grant
- 2002-06-14 JP JP2003506264A patent/JP4314340B2/ja not_active Expired - Fee Related
- 2002-06-14 AT AT02762286T patent/ATE360014T1/de not_active IP Right Cessation
- 2002-06-14 EP EP02762286A patent/EP1406893B1/de not_active Expired - Lifetime
- 2002-06-14 CA CA002446931A patent/CA2446931A1/en not_active Abandoned
- 2002-06-14 DE DE60219630T patent/DE60219630T2/de not_active Expired - Lifetime
- 2002-06-14 DK DK02762286T patent/DK1406893T3/da active
- 2002-06-14 US US10/171,705 patent/US6987104B2/en not_active Expired - Fee Related
- 2002-06-14 PT PT02762286T patent/PT1406893E/pt unknown
- 2002-06-14 ES ES02762286T patent/ES2283589T3/es not_active Expired - Lifetime
- 2002-06-14 CN CNA028109902A patent/CN1512991A/zh active Pending
- 2002-06-14 BR BR0210422-9A patent/BR0210422A/pt not_active IP Right Cessation
-
2005
- 2005-06-13 US US11/151,131 patent/US7612059B2/en not_active Expired - Fee Related
-
2007
- 2007-06-28 CY CY20071100856T patent/CY1107688T1/el unknown
-
2008
- 2008-12-03 US US12/327,245 patent/US20090149509A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR0210422A (pt) | 2004-08-17 |
| US20050277683A1 (en) | 2005-12-15 |
| US20030069223A1 (en) | 2003-04-10 |
| DE60219630T2 (de) | 2007-12-27 |
| CN1512991A (zh) | 2004-07-14 |
| JP2005501020A (ja) | 2005-01-13 |
| PT1406893E (pt) | 2007-07-12 |
| JP4314340B2 (ja) | 2009-08-12 |
| CA2446931A1 (en) | 2002-12-27 |
| US7612059B2 (en) | 2009-11-03 |
| ATE360014T1 (de) | 2007-05-15 |
| WO2002102791A1 (en) | 2002-12-27 |
| EP1406893A1 (de) | 2004-04-14 |
| CY1107688T1 (el) | 2013-04-18 |
| ES2283589T3 (es) | 2007-11-01 |
| US20090149509A1 (en) | 2009-06-11 |
| EP1406893B1 (de) | 2007-04-18 |
| US6987104B2 (en) | 2006-01-17 |
| DK1406893T3 (da) | 2007-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| R082 | Change of representative |
Ref document number: 1406893 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE |