BR9907689A - Agentes antibacterianos - Google Patents
Agentes antibacterianosInfo
- Publication number
- BR9907689A BR9907689A BR9907689-6A BR9907689A BR9907689A BR 9907689 A BR9907689 A BR 9907689A BR 9907689 A BR9907689 A BR 9907689A BR 9907689 A BR9907689 A BR 9907689A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- group
- independently
- alk
- antibacterial agents
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydroxy, mercapto Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/14—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Patente de Invenção: <B>"AGENTES ANTIBACTERIANOS"<D>. Esta invenção proporciona compostos de fórmula (I) que são antibacterianos: onde R~ 1~ representa hidrogênio ou C~ 1~-C~ 6~ alquila ou C~ 1~-C~ 6~ alquila substituída por um ou mais átomos de halogênio; R~ 2~ representa um grupo R~ 10~-(X)~ n~-(ALK)~ m~- onde R~ 10~ representa hidrogênio ou um grupo C~ 1~-C~ 6~ alquila, C~ 2~-C~ 6~ alquenila, C~ 2~-C~ 6~ alquinila, cicloalquila, arila ou heterociclila, qualquer dos quais podem ser não-substituído ou substituído por (C~ 1~-C~ 6~)alquila, (C~ 1~-C~ 6~)alcóxi, hidróxi, mercapto, (C~ 1~-C~ 6~)alquiltio, amino, halo (incluindo flúor, cloro, bromo e iodo), trifluormetila, ciano, nitro, -COOH, -CONH~ 2~, -COOR^ A^, -NHCOR^ A^, -CONHR^ A^, -NHR^ A^, -NR^ A^R^ B^ ou -CONR^ A^ R^ B^ onde R^ A^ e R^ B^ são independentemente um grupo (C~ 1~-C~ 6~)alquila, e ALK representa um radical C~ 1~-C~ 6~ alquileno, C~ 2~-C~ 6~ alquenileno ou C~ 2~-C~ 6~ alquinileno divalente normal ou ramificado e poderá ser interrompido por uma ou mais ligações não-adjacentes -NH-, -O- ou -S-, X representa -NH-, -O- ou -S-, e m e n são independentemente 0 ou 1; e A representa um grupo como definido no relatório descritivo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9802549.7A GB9802549D0 (en) | 1998-02-07 | 1998-02-07 | Antibacterial agents |
GBGB9806300.1A GB9806300D0 (en) | 1998-03-24 | 1998-03-24 | Antibacterial agents |
GBGB9810463.1A GB9810463D0 (en) | 1998-05-16 | 1998-05-16 | Antibacterial agents |
GBGB9828318.7A GB9828318D0 (en) | 1998-12-22 | 1998-12-22 | Antibacterial agents |
PCT/GB1999/000386 WO1999039704A1 (en) | 1998-02-07 | 1999-02-05 | Antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9907689A true BR9907689A (pt) | 2000-11-14 |
Family
ID=27451747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9907689-6A BR9907689A (pt) | 1998-02-07 | 1999-02-05 | Agentes antibacterianos |
Country Status (21)
Country | Link |
---|---|
US (4) | US6423690B1 (pt) |
EP (1) | EP1052984B1 (pt) |
JP (1) | JP2002502815A (pt) |
KR (1) | KR100600518B1 (pt) |
CN (1) | CN1298299A (pt) |
AT (1) | ATE266394T1 (pt) |
AU (1) | AU749699B2 (pt) |
BR (1) | BR9907689A (pt) |
CA (1) | CA2320476A1 (pt) |
DE (1) | DE69917221T2 (pt) |
DK (1) | DK1052984T3 (pt) |
ES (1) | ES2221359T3 (pt) |
GB (1) | GB2349884A (pt) |
HU (1) | HUP0102901A3 (pt) |
IL (1) | IL137312A (pt) |
NO (1) | NO20003969L (pt) |
NZ (1) | NZ505675A (pt) |
PL (1) | PL194240B1 (pt) |
PT (1) | PT1052984E (pt) |
TR (1) | TR200002311T2 (pt) |
WO (1) | WO1999039704A1 (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL194240B1 (pl) * | 1998-02-07 | 2007-05-31 | British Biotech Pharm | Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy |
GB9810464D0 (en) * | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
GB9907055D0 (en) * | 1999-03-29 | 1999-05-19 | British Biotech Pharm | Antibacterial agents |
JP2002541197A (ja) * | 1999-04-09 | 2002-12-03 | ブリティッシュ バイオテック ファーマシューティカルズ リミテッド | 抗菌剤 |
AU766881B2 (en) * | 1999-08-10 | 2003-10-23 | British Biotech Pharmaceuticals Limited | Antibacterial agents |
ATE293600T1 (de) * | 1999-08-10 | 2005-05-15 | Vernalis Oxford Ltd | Antibakterielle mittel |
JP4576649B2 (ja) * | 1999-10-29 | 2010-11-10 | 東ソー株式会社 | 新規オキサゾリジノン誘導体及びその用途 |
EP1237862A1 (en) * | 1999-12-17 | 2002-09-11 | Versicor, Inc. | Succinate compounds, compositions and methods of use and preparation |
AR029916A1 (es) * | 2000-05-05 | 2003-07-23 | Smithkline Beecham Corp | N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas |
AR028075A1 (es) * | 2000-05-05 | 2003-04-23 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
WO2002028829A2 (en) * | 2000-09-25 | 2002-04-11 | Questcor Pharmaceuticals, Inc. | Peptide deformylase inhibitors |
US7173053B2 (en) | 2000-11-23 | 2007-02-06 | British Biotech Pharmaceuticals Limited | N-formyl hydroxylamine derivatives as inhibitors of bacterial polypeptide formylase for treating microbial infections |
US6797730B2 (en) * | 2001-03-01 | 2004-09-28 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
US6967220B2 (en) * | 2001-04-05 | 2005-11-22 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
US7018642B2 (en) | 2001-04-27 | 2006-03-28 | The Procter & Gamble Company | Compounds, compositions, and methods for controlling biofilms |
AU2002256505B2 (en) * | 2001-05-11 | 2008-06-26 | Eisai Inc. | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors |
WO2002098901A2 (en) * | 2001-06-05 | 2002-12-12 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
US6987104B2 (en) | 2001-06-15 | 2006-01-17 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use |
AR036053A1 (es) * | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
GB0128943D0 (en) | 2001-12-04 | 2002-01-23 | Novo Pharmaceuticals De Ltd | Bacterial enzyme inhibitors |
GB0208579D0 (en) * | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
UY27813A1 (es) * | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
WO2004018453A1 (ja) * | 2002-08-23 | 2004-03-04 | Dainippon Pharmaceutical Co., Ltd. | プロリン誘導体 |
WO2004026824A1 (en) * | 2002-09-19 | 2004-04-01 | Novartis Ag | Process for preparing intermediates |
AU2003296960A1 (en) | 2002-12-11 | 2004-06-30 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
WO2004062601A2 (en) | 2003-01-08 | 2004-07-29 | Chiron Corporation | Antibacterial agents |
MXPA05008842A (es) * | 2003-02-21 | 2005-10-05 | Novartis Ag | Proceso quimico. |
KR100527361B1 (ko) * | 2003-04-01 | 2005-11-09 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
TW200427458A (en) * | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
CA2526753A1 (en) * | 2003-05-29 | 2004-12-23 | Inhibitex, Inc. | Sdr proteins from staphylococcus capitis and their use in preventing and treating infections |
US20070060753A1 (en) * | 2003-06-26 | 2007-03-15 | Joel Slade | Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines |
KR100750328B1 (ko) * | 2004-12-18 | 2007-08-20 | 한국생명공학연구원 | 곰팡이 Bionectra byssicola F120생산하는 새로운 펩타이드 디포밀레이즈 저해 물질과 그항균활성 |
KR100648133B1 (ko) * | 2005-04-25 | 2006-11-23 | 일동제약주식회사 | 펩티드 데포르밀라제 저해제로서 신규의 히드록사믹 산유도체 및 그 제조방법 |
GT200600196A (es) | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
WO2007060132A1 (en) * | 2005-11-24 | 2007-05-31 | Laboratoires Serono S.A. | N-hydroxyamide derivatives and use thereof |
WO2007067904A2 (en) * | 2005-12-06 | 2007-06-14 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
KR100878446B1 (ko) * | 2007-06-07 | 2009-01-13 | 일동제약주식회사 | 신규 펩티드 데포르밀라제 저해제 화합물 및 그 제조방법 |
EP2170814B1 (en) | 2007-06-12 | 2016-08-17 | Achaogen, Inc. | Antibacterial agents |
CN101434570B (zh) * | 2007-11-16 | 2011-02-02 | 上海医药工业研究院 | 吡咯烷衍生物及其制备方法和应用 |
EP2224973B1 (en) * | 2007-11-29 | 2016-04-20 | Inolex Investment Corporation | Preservatives for cosmetic, toiletry and pharmaceutical compositions |
JP2011517313A (ja) | 2007-12-11 | 2011-06-02 | ビアメト ファーマシューティカルズ,インク. | 金属結合部分を標的化部分と組み合わせて使用する金属酵素阻害剤 |
CA2735929C (en) * | 2008-09-19 | 2013-12-17 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
CA2899583A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
CN102452998B (zh) * | 2010-10-20 | 2014-12-10 | 天津药物研究院 | N-甲酰羟胺类化合物及其制备方法和用途 |
UA107423C2 (en) | 2011-03-07 | 2014-12-25 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
SG193458A1 (en) | 2011-04-08 | 2013-10-30 | Pfizer | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
CA2830920C (en) | 2011-04-08 | 2015-07-14 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
EP2847168A1 (en) | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
FR3098217B1 (fr) * | 2019-07-05 | 2023-04-21 | Pharmaleads | N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP) |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3166587A (en) * | 1963-07-29 | 1965-01-19 | Olin Mathieson | Alkanoyl, hydroxy-ureas |
US3692787A (en) * | 1970-02-16 | 1972-09-19 | Burroughs Wellcome Co | Substituted 2,4-diamino-5-benzyl pyrimidines |
FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
DE3320175A1 (de) * | 1983-06-03 | 1984-12-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aminosaeure- bzw. peptidderivate, verfahren zu deren herstellung und verwendung als arzneimittel |
DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
ATE171042T1 (de) * | 1989-08-01 | 1998-10-15 | Scripps Research Inst | Verfahren und zusammensetzungen zur verbesserung der symptome von sepsis |
GB9220845D0 (en) | 1992-10-03 | 1992-11-18 | British Bio Technology | Vasoactive peptide inhibition |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
US6037472A (en) | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
ATE181055T1 (de) * | 1994-05-28 | 1999-06-15 | British Biotech Pharm | Succinyl hydroxamsäure-, n-formyl-n-hydroxy- aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease- inhibitoren |
WO1997038705A1 (en) * | 1996-04-12 | 1997-10-23 | Bristol-Myers Squibb Company | N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors |
EP0863152A3 (en) * | 1997-02-10 | 2000-04-19 | Smithkline Beecham Corporation | Streptococcus pneumoniae Def1 protein |
ZA981532B (en) | 1997-02-26 | 1999-08-24 | Glaxo Group Ltd | Reverse hydroxamate derivatives as matrix metalloprotease inhibitors, metalloprotease inhibitors, and TNF alpha inhibitors. |
US6586578B1 (en) * | 1997-05-21 | 2003-07-01 | Smithkline Beecham Corporation | Defl |
US5962666A (en) * | 1997-09-16 | 1999-10-05 | Smithkline Beecham Corporation | Deformylase |
PL194240B1 (pl) * | 1998-02-07 | 2007-05-31 | British Biotech Pharm | Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy |
GB9810464D0 (en) * | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
ATE293600T1 (de) * | 1999-08-10 | 2005-05-15 | Vernalis Oxford Ltd | Antibakterielle mittel |
-
1999
- 1999-02-05 PL PL99342296A patent/PL194240B1/pl unknown
- 1999-02-05 DE DE69917221T patent/DE69917221T2/de not_active Expired - Fee Related
- 1999-02-05 WO PCT/GB1999/000386 patent/WO1999039704A1/en not_active Application Discontinuation
- 1999-02-05 CN CN99802752A patent/CN1298299A/zh active Pending
- 1999-02-05 NZ NZ505675A patent/NZ505675A/xx unknown
- 1999-02-05 AT AT99904977T patent/ATE266394T1/de not_active IP Right Cessation
- 1999-02-05 BR BR9907689-6A patent/BR9907689A/pt not_active Application Discontinuation
- 1999-02-05 EP EP99904977A patent/EP1052984B1/en not_active Expired - Lifetime
- 1999-02-05 TR TR2000/02311T patent/TR200002311T2/xx unknown
- 1999-02-05 PT PT99904977T patent/PT1052984E/pt unknown
- 1999-02-05 KR KR1020007008492A patent/KR100600518B1/ko not_active IP Right Cessation
- 1999-02-05 HU HU0102901A patent/HUP0102901A3/hu unknown
- 1999-02-05 IL IL13731299A patent/IL137312A/xx active IP Right Grant
- 1999-02-05 ES ES99904977T patent/ES2221359T3/es not_active Expired - Lifetime
- 1999-02-05 AU AU25292/99A patent/AU749699B2/en not_active Ceased
- 1999-02-05 DK DK99904977T patent/DK1052984T3/da active
- 1999-02-05 CA CA002320476A patent/CA2320476A1/en not_active Abandoned
- 1999-02-05 GB GB0016855A patent/GB2349884A/en not_active Withdrawn
- 1999-02-05 US US09/355,489 patent/US6423690B1/en not_active Expired - Fee Related
- 1999-02-05 JP JP2000530203A patent/JP2002502815A/ja not_active Withdrawn
-
2000
- 2000-08-04 NO NO20003969A patent/NO20003969L/no not_active Application Discontinuation
-
2002
- 2002-04-30 US US10/134,754 patent/US6787522B2/en not_active Expired - Fee Related
-
2004
- 2004-07-29 US US10/901,065 patent/US7148198B2/en not_active Expired - Fee Related
-
2006
- 2006-08-02 US US11/497,277 patent/US7323448B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9907689A (pt) | Agentes antibacterianos | |
BR9910488A (pt) | Derivados do ácido hidroxâmico como antibacterianos | |
BR0012666A (pt) | Imidazoimidazóis e triazóis como agentes anti-inflamatórios | |
BR9908275A (pt) | Inibidores de enzimas fosfolipase | |
BR9815039A (pt) | Inibição da oxidação de lipoproteìna | |
PE14199A1 (es) | Agonistas de 5-ht1f | |
BR0312421A (pt) | Uso de inibidores de cept e opcionalmente inibidores hmg coa redutase e/ou agentes anti-hipertensivos | |
BR0112030A (pt) | Novos compostos que possuem atividade antibacteriana, antifúngica ou antitumor | |
BR0008922A (pt) | Compostos úteis como agentes antiinflamatórios | |
BR9909242A (pt) | Inibidores de fosfolipase a2 | |
BR9908004A (pt) | Composto, composição e método para prevençãoou supressão de uma infecção viral | |
BR0206381A (pt) | Derivados do ácido fumárico como inibidor de nf-kappab | |
BR9914044A (pt) | ésteres tetrahidropirido | |
ECSP045004A (es) | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes | |
PA8543201A1 (es) | DERIVADOS DE DIHIDRO-BENZO [B] [1,4]-DIAZEPIN-2-ONA COMO ANTAGONISTAS I DE mGluR2 | |
BR0318278A (pt) | compostos de éter aminocicloexìlico e usos dos mesmo | |
BR0314390A (pt) | Moduladores aromáticos dos receptores hepáticos x | |
BR0215058A (pt) | 2-fenil benzofuranos substituìdos como agentes estrogênicos | |
BR9907655A (pt) | Derivados de ácido di-hidróxi-hexanóico | |
BR0009211A (pt) | Derivados de resorcinol | |
BR0012327A (pt) | Pirrolidinas e piperidinas neurotróficas, e composições e métodos relacionados | |
AR030919A1 (es) | Feniluracilos substituidos, composiciones herbicidas, y empleo de dichos compuestos para la lucha contra las plantas indeseables | |
BR9909870A (pt) | Pirrolidinas como inibidores de neuraminidases | |
ID25478A (id) | Agonis 5-ht1f | |
BR0214377A (pt) | composição herbicida, e, métodos para reforçar a atividade herbicida de um inibidor de protoporfirinogeno oxidase, e para controlar o crescimento de planta |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT.CL: A61K 31/16, A61K 31/164, A61K 31/165, A61K 31/40, A61K 31/44, A61K 31/47, A61K31/495, A61K 31/445, C07C 259/06, A61P 31/04 Ipc: A61K 31/16 (2009.01), A61K 31/164 (2009.01), A61K |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM ART. 8O, 10 ( VIII), 11, 13, 24 E 25 DA LPI. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |