MXPA05008842A - Proceso quimico. - Google Patents

Proceso quimico.

Info

Publication number
MXPA05008842A
MXPA05008842A MXPA05008842A MXPA05008842A MXPA05008842A MX PA05008842 A MXPA05008842 A MX PA05008842A MX PA05008842 A MXPA05008842 A MX PA05008842A MX PA05008842 A MXPA05008842 A MX PA05008842A MX PA05008842 A MXPA05008842 A MX PA05008842A
Authority
MX
Mexico
Prior art keywords
intermediates
preparation
alkanes
chemical process
make use
Prior art date
Application number
MXPA05008842A
Other languages
English (en)
Inventor
John Girgis Michael
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MXPA05008842A publication Critical patent/MXPA05008842A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procesos mejorados para preparar intermediarios utiles para la preparacion de N- [1-oxo-2 -alquil-3- (N-hidroxi -formamido) -propil] -(carbonil -amino -aril o -heteroaril)- azaciclo 4- 7alcanos o tiazaciclo 4-7 alcanos, que tienen una o mas de las siguientes caracteristicas: (1) hacen uso de un intermediario particular de °-lactama; (2) que hacen uso de agentes de resolucion particulares, de acidos propionicos sustituidos enantiomericamente puros, en especial acido (R)-2 -butil-3 -hidroxi- propionico; (3) que evitan el uso de peroxido de hidrogeno; y (4) que facilitan la desbencilacion selectiva, reduciendo la produccion de subproductos de desecho.
MXPA05008842A 2003-02-21 2004-02-20 Proceso quimico. MXPA05008842A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44901503P 2003-02-21 2003-02-21
US44901603P 2003-02-21 2003-02-21
US44901703P 2003-02-21 2003-02-21
PCT/US2004/005159 WO2004076053A2 (en) 2003-02-21 2004-02-20 Chemical process for the preparation of intermediates to obtain n-formyl hydroxylamine compounds

Publications (1)

Publication Number Publication Date
MXPA05008842A true MXPA05008842A (es) 2005-10-05

Family

ID=32931324

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05008842A MXPA05008842A (es) 2003-02-21 2004-02-20 Proceso quimico.

Country Status (10)

Country Link
US (2) US7452999B2 (es)
EP (1) EP1599440A2 (es)
JP (1) JP2006519786A (es)
CN (2) CN101092342A (es)
AU (1) AU2004216178B2 (es)
BR (1) BRPI0407448A (es)
CA (1) CA2516465A1 (es)
MX (1) MXPA05008842A (es)
PL (1) PL379008A1 (es)
WO (1) WO2004076053A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2446931A1 (en) 2001-06-15 2002-12-27 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds
DK1542968T3 (da) 2002-09-19 2009-04-20 Novartis Ag Fremgangsmåde til fremstilling af mellemforbindelser
PL379008A1 (pl) 2003-02-21 2006-06-26 Novartis Ag Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
KR20080095895A (ko) * 2006-03-03 2008-10-29 노파르티스 아게 Ｎ―포르밀 히드록실아민 화합물
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
WO2011023761A1 (en) 2009-08-28 2011-03-03 Lonza Ag Method for preventing plugging of a continuous-reaction channel-system and micro-reactor for carrying out the method
JPWO2013094498A1 (ja) * 2011-12-19 2015-04-27 住友化学株式会社 α−置換−β−アミノ酸エステルのラセミ化方法
CN114685277A (zh) * 2020-12-31 2022-07-01 苏州瑞博生物技术股份有限公司 化合物及羟基丙酸盐类化合物的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543052A (en) * 1978-09-22 1980-03-26 Sumitomo Chem Co Ltd Preparation of optically active gamma hydroxynonanoic acid
JPH01175956A (ja) * 1988-01-04 1989-07-12 Muraki Buhin Kk 光学的に純粋な３−ヒドロキシ酸類の精製法
JP4218040B2 (ja) * 1997-12-26 2009-02-04 曽田香料株式会社 有機酸とアミンの複合塩の製造法
DK1052984T3 (da) 1998-02-07 2004-09-20 Vernalis Oxford Ltd Antibakterielle midler
AU1481301A (en) 1999-11-10 2001-06-06 Penn State Research Foundation, The Chiral phosphines, transition metal complexes thereof and uses thereof in asymmetric reactions
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6852752B2 (en) 1999-12-17 2005-02-08 Vicuron Pharmaceuticals Inc. Urea compounds, compositions and methods of use and preparation
CA2446931A1 (en) 2001-06-15 2002-12-27 Vicuron Pharmaceuticals Inc. Pyrrolidine bicyclic compounds
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
DK1542968T3 (da) 2002-09-19 2009-04-20 Novartis Ag Fremgangsmåde til fremstilling af mellemforbindelser
PL379008A1 (pl) 2003-02-21 2006-06-26 Novartis Ag Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych
TW200427458A (en) 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
BRPI0411921A (pt) 2003-06-26 2006-08-15 Novartis Ag processo para preparar intermediários úteis para preparar determinadas hidroxilaminas de n-formila antibacterianas

Also Published As

Publication number Publication date
EP1599440A2 (en) 2005-11-30
PL379008A1 (pl) 2006-06-26
AU2004216178B2 (en) 2008-07-03
CA2516465A1 (en) 2004-09-10
WO2004076053A3 (en) 2004-12-02
AU2004216178A1 (en) 2004-09-10
JP2006519786A (ja) 2006-08-31
CN101092342A (zh) 2007-12-26
BRPI0407448A (pt) 2006-01-31
US20090131707A1 (en) 2009-05-21
US7452999B2 (en) 2008-11-18
WO2004076053A2 (en) 2004-09-10
US20070179298A1 (en) 2007-08-02
CN1759097A (zh) 2006-04-12

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