PE14199A1 - Agonistas de 5-ht1f - Google Patents
Agonistas de 5-ht1fInfo
- Publication number
- PE14199A1 PE14199A1 PE1997001023A PE00102397A PE14199A1 PE 14199 A1 PE14199 A1 PE 14199A1 PE 1997001023 A PE1997001023 A PE 1997001023A PE 00102397 A PE00102397 A PE 00102397A PE 14199 A1 PE14199 A1 PE 14199A1
- Authority
- PE
- Peru
- Prior art keywords
- ht1f
- formula
- agonists
- compounds
- ht1f agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: A-B ES C=CH o CH-CH2; "X" ES NR1SO2R2, NHC(Q)NR3R4, NHCOOR5, NR1COR6; "Q" ES O o S; R ES H, ALQUILO C1-C6, BENCILO o FENILETILO; R1 ES H o ALQUILO C1-C4; R2 ES ALQUILO C1-C4 o FENILO OPCIONALMENTE SUSTITUIDO; R3 Y R4 SON H, ALQUILO C1-C6, ALQUENILO C3-C6, CICLOALQUILO C3-C8, FENILO, HETEROARILO, ENTRE OTROS, o R3 Y R4 JUNTO CON EL NITROGENO AL CUAL ESTAN UNIDOS FORMAN UN ANILO DE PIRROLIDINA, PIPERIDINA, PIPERAZINA, MORFOLINA o TIOMORFOLINA; R5 ES ALQUILO C1-C6, ALQUENILO C3-C6, FENILO OPCIONALMENTE SUSTITUIDO, CICLOALQUILO C3-C8, ENTRE OTROS; R6 ES ALQUILO C1-C10 OPCIONALMENTE SUSTITUIDO, ALQUENILO C2-C10, ALQUINILO C2-C10, CICLOALQUILO C3-C8, FENILO OPCIONALMENTE SUSTITUIDO, NAFTILO, FENIL(ALQUILENO C1-C4) OPCIONALMENTE SUSTITUIDO, ENTRE OTROS. UN COMPUESTO (I) PREFERIDO ES: 5-(N-[PROPIONIL]AMINO)-3-(1-METILPIPERIDIN-4-IL)PIRROLO[3,2-b]PIRIDINA. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO AGONISTAS SELECTIVOS DEL RECEPTOR DE SEROTONINA (5-HT) 1F, QUE EVITAN LOS EFECTOS SECUNDARIOS DE VASOCONSTRICCION ASOCIADOS A VARIOS SUBTIPOS DE RECEPTORES DE SEROTONINA, SIENDO UTILES EN EL TRATAMIENTO DE LA MIGRANA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3095096P | 1996-11-15 | 1996-11-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE14199A1 true PE14199A1 (es) | 1999-02-12 |
Family
ID=21856862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997001023A PE14199A1 (es) | 1996-11-15 | 1997-11-13 | Agonistas de 5-ht1f |
Country Status (17)
Country | Link |
---|---|
US (3) | US5817671A (es) |
EP (1) | EP0842934B1 (es) |
JP (1) | JP2001503774A (es) |
AT (1) | ATE253063T1 (es) |
AU (1) | AU5435298A (es) |
CA (1) | CA2271272A1 (es) |
CO (1) | CO4910133A1 (es) |
DE (1) | DE69725825T2 (es) |
DK (1) | DK0842934T3 (es) |
ES (1) | ES2210463T3 (es) |
ID (1) | ID18883A (es) |
IL (1) | IL129592A0 (es) |
NO (1) | NO991974D0 (es) |
PE (1) | PE14199A1 (es) |
PT (1) | PT842934E (es) |
WO (1) | WO1998020875A1 (es) |
ZA (1) | ZA979961B (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5905084A (en) * | 1997-11-14 | 1999-05-18 | Eli Lilly And Company | 5-HTIF -agonists effective in treating migraine |
ZA989389B (en) * | 1997-11-14 | 2000-04-14 | Lilly Co Eli | Pyrrolo [3,2-b] pyridine processes and intermediates. |
US6133290A (en) * | 1998-07-31 | 2000-10-17 | Eli Lilly And Company | 5-HT1F agonists |
GB9823845D0 (en) * | 1998-11-02 | 1998-12-23 | Lilly Co Eli | Pharmaceutical compounds |
WO2000034266A1 (en) * | 1998-12-11 | 2000-06-15 | Eli Lilly And Company | Indole derivatives and their use as 5-ht1f agonists |
EP1465869B1 (en) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulators of lxr |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
ES2388547T3 (es) | 2003-04-18 | 2012-10-16 | Eli Lilly And Company | Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas de 5-HT 1F |
UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
NZ547327A (en) * | 2003-11-21 | 2009-08-28 | Array Biopharma Inc | AKT protein kinase inhibitors |
ES2291978T3 (es) | 2003-12-17 | 2008-03-01 | Eli Lilly And Company | Compuestos de (4-aminociclohexen-1-il)fenilo y (4-aminociclohexen-1-il)piridinilo sustituidos como agonistas de 5-ht1f. |
US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2008006032A1 (en) * | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
ATE532789T1 (de) | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
RU2486181C2 (ru) | 2007-07-05 | 2013-06-27 | Эррэй Биофарма Инк. | Пиримидилциклопентаны как ингибиторы акт-протеинкиназ |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
EP2173723B3 (en) * | 2007-07-05 | 2014-11-19 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
AU2009204019B2 (en) * | 2008-01-09 | 2014-02-20 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
ES2422733T3 (es) * | 2008-01-09 | 2013-09-13 | Array Biopharma Inc | Pirimidilciclopentanos hidroxilados como inhibidores de proteínas cinasas AKT |
NZ596161A (en) * | 2009-04-02 | 2013-11-29 | Colucid Pharmaceuticals Inc | Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide |
US8697876B2 (en) | 2010-04-02 | 2014-04-15 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists |
CN103857395A (zh) | 2011-04-01 | 2014-06-11 | 基因泰克公司 | Akt抑制剂化合物和阿比特龙的组合及使用方法 |
JP6147246B2 (ja) | 2011-04-01 | 2017-06-14 | ジェネンテック, インコーポレイテッド | Akt及びmek阻害剤化合物の組み合わせ、及び使用方法 |
BG111544A (bg) | 2013-07-29 | 2015-01-30 | Николай Цветков | Субституирани бензамидни производни като in vitro mao-b инхибитори |
DK3027603T3 (en) * | 2013-08-02 | 2018-09-17 | Pfizer | HETEROBICYCLOARYL-RORC2 INHIBITORS AND METHODS FOR USING IT |
MA40759A (fr) * | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
PL3416964T3 (pl) * | 2016-02-19 | 2021-10-18 | Phoenix Molecular Designs | Pochodne 6-okso-n-(1-(benzylo)-1h-pirazol-4-ilo)-6,7,8,9-tetrahydropirydo[3’,2’:4,5]pirolo[1,2-a]pirazyno-2-karboksyamidu jako inhibitory kinazy rybosomalnej s6 p90 (rsk) do leczenia nowotworu złośliwego |
AU2019323450A1 (en) | 2018-08-24 | 2021-02-11 | Sunshine Lake Pharma Co., Ltd. | Pyridinylmethylenepiperidine derivatives and uses thereof |
TWI776175B (zh) | 2019-07-09 | 2022-09-01 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體,以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3080374A (en) * | 1962-02-08 | 1963-03-05 | Abbott Lab | 2-guanidino-3-nitropyridine and derivatives thereof |
WO1990007926A1 (en) * | 1989-01-20 | 1990-07-26 | Pfizer Inc. | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines |
US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
GB9423460D0 (en) * | 1994-11-21 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
CN1184425A (zh) * | 1995-03-20 | 1998-06-10 | 伊莱利利公司 | 5-取代-3-(1,2,3,6-四氢吡啶-4-基)-和3-(哌啶-4-基)-1h-吲哚:新型5-ht1f激动剂 |
-
1997
- 1997-11-05 ZA ZA979961A patent/ZA979961B/xx unknown
- 1997-11-12 DK DK97309106T patent/DK0842934T3/da active
- 1997-11-12 PT PT97309106T patent/PT842934E/pt unknown
- 1997-11-12 EP EP97309106A patent/EP0842934B1/en not_active Expired - Lifetime
- 1997-11-12 ES ES97309106T patent/ES2210463T3/es not_active Expired - Lifetime
- 1997-11-12 DE DE69725825T patent/DE69725825T2/de not_active Expired - Fee Related
- 1997-11-12 AT AT97309106T patent/ATE253063T1/de not_active IP Right Cessation
- 1997-11-13 PE PE1997001023A patent/PE14199A1/es not_active Application Discontinuation
- 1997-11-13 CO CO97066711A patent/CO4910133A1/es unknown
- 1997-11-13 ID IDP973668A patent/ID18883A/id unknown
- 1997-11-13 AU AU54352/98A patent/AU5435298A/en not_active Abandoned
- 1997-11-13 IL IL12959297A patent/IL129592A0/xx unknown
- 1997-11-13 JP JP52277798A patent/JP2001503774A/ja not_active Ceased
- 1997-11-13 CA CA002271272A patent/CA2271272A1/en not_active Abandoned
- 1997-11-13 WO PCT/US1997/020630 patent/WO1998020875A1/en active Application Filing
- 1997-11-14 US US08/969,851 patent/US5817671A/en not_active Expired - Fee Related
-
1998
- 1998-07-09 US US09/112,560 patent/US5919936A/en not_active Expired - Fee Related
- 1998-07-09 US US09/112,562 patent/US5998622A/en not_active Expired - Fee Related
-
1999
- 1999-04-26 NO NO991974A patent/NO991974D0/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2271272A1 (en) | 1998-05-22 |
ATE253063T1 (de) | 2003-11-15 |
WO1998020875A1 (en) | 1998-05-22 |
US5998622A (en) | 1999-12-07 |
ES2210463T3 (es) | 2004-07-01 |
US5817671A (en) | 1998-10-06 |
AU5435298A (en) | 1998-06-03 |
DE69725825D1 (de) | 2003-12-04 |
DE69725825T2 (de) | 2004-08-12 |
JP2001503774A (ja) | 2001-03-21 |
ZA979961B (en) | 1999-05-05 |
PT842934E (pt) | 2004-03-31 |
EP0842934A1 (en) | 1998-05-20 |
US5919936A (en) | 1999-07-06 |
EP0842934B1 (en) | 2003-10-29 |
NO991974L (no) | 1999-04-26 |
ID18883A (id) | 1998-05-20 |
IL129592A0 (en) | 2000-02-29 |
DK0842934T3 (da) | 2004-03-08 |
CO4910133A1 (es) | 2000-04-24 |
NO991974D0 (no) | 1999-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |