BG111544A - Субституирани бензамидни производни като in vitro mao-b инхибитори - Google Patents
Субституирани бензамидни производни като in vitro mao-b инхибиториInfo
- Publication number
- BG111544A BG111544A BG111544A BG11154413A BG111544A BG 111544 A BG111544 A BG 111544A BG 111544 A BG111544 A BG 111544A BG 11154413 A BG11154413 A BG 11154413A BG 111544 A BG111544 A BG 111544A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- substituted
- hydrogen atoms
- halogen atom
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретението се отнася до субституирани бензамидни производни с обща формула I където А1 и А2 са -N или -СН, така че ако А1 е -N, А2 е -СН и ако А2 е -N, то А1 е -СН; R е водород, -(С1-С3)-алкил с права или разклонена верига, -(С1-С3)-алкил, където един, два или три водородни атома могат да бъдат субституирани с халогенен атом или хидроксилна група, -(С1-С3)-O-(С1-С3), -(С1-С3)-O-(С1-С3), където един, два или три водородни атома могат да бъдат заместени с халогенен атом или е група с обща формула където R3 и R4 са едновременно или независимо един от друг халоген, хидрокси, -(С1-С3)-алкил, -(С1-С3)-алкил, в молекулата на който един, два или три водородни атома могат да бъдат субституирани с халогенен атом или хидроксилна група, -О-(С1-С3)-алкил, -О-(С1-С3)-алкил, в молекулата на който един, два или три водородни атома могат да бъдат субституирани с халогенен атом, -О-(С1-С3)-О-(С1-С3), -О-(С1-С3)-О-(С1-С3), където един, два или три водородни атома могат да бъдат субституирани с халогенен атом; R1 и R2 едновременно или независимо един от друг са халоген, хидрокси, -(С1-С3)-алкил и -(С1-С3)-алкил, където един, два или три водородни атома могат да бъдат субституирани с халогенен атом или хидроксилна група, -О-(С1-С3)-алкил, -О-(С1-С3)-алкил, където един, два или три водородни атома могат да бъдат субституирани с халогенен атом, -О-(С1-С3)-О-(С1-С3), -О-(С1-С3)-О-(С1-С3), където един, два или три водородни атома могат да бъдат субституирани с халогенен атом, както и техни фармацевтично приемливи соли, изомери или смеси от тях. Съединенията са приложими като in vitro селективни МАО-В инхибитори за превенция и лечение на акутни и хронични неврологични, когнитивни и невродегенеративни заболявания и по-специално за превенция и лечение на Паркинсонова болест и Алцхаймер. 4 претенции, 1 фигура
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG111544A BG111544A (bg) | 2013-07-29 | 2013-07-29 | Субституирани бензамидни производни като in vitro mao-b инхибитори |
EP14831149.1A EP2991986B1 (en) | 2013-07-29 | 2014-07-11 | Substituted benzamide derivatives as mao-b inhibitors |
PCT/BG2014/000027 WO2015013777A2 (en) | 2013-07-29 | 2014-07-11 | Substituted benzamide derivatives as in vitro mao-b inhibitors |
US14/904,893 US9738640B2 (en) | 2013-07-29 | 2014-07-11 | Substituted benzamide derivatives as in vitro MAO-B inhibitors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG111544A BG111544A (bg) | 2013-07-29 | 2013-07-29 | Субституирани бензамидни производни като in vitro mao-b инхибитори |
Publications (1)
Publication Number | Publication Date |
---|---|
BG111544A true BG111544A (bg) | 2015-01-30 |
Family
ID=52432494
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG111544A BG111544A (bg) | 2013-07-29 | 2013-07-29 | Субституирани бензамидни производни като in vitro mao-b инхибитори |
Country Status (4)
Country | Link |
---|---|
US (1) | US9738640B2 (bg) |
EP (1) | EP2991986B1 (bg) |
BG (1) | BG111544A (bg) |
WO (1) | WO2015013777A2 (bg) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024124464A1 (zh) * | 2022-12-15 | 2024-06-20 | 武汉睿健医药科技有限公司 | 一种诱导间质细胞向上皮细胞转化及重编程的诱导剂 |
WO2024124463A1 (zh) * | 2022-12-15 | 2024-06-20 | 武汉睿健医药科技有限公司 | 一种吡咯并吡啶衍生物及其药物组合物与应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA979961B (en) | 1996-11-15 | 1999-05-05 | Lilly Co Eli | 5-HT1F agonists |
US20050075364A1 (en) | 2003-07-01 | 2005-04-07 | Kap-Sun Yeung | Indole, azaindole and related heterocyclic N-substituted piperazine derivatives |
JP4898683B2 (ja) | 2004-09-03 | 2012-03-21 | ユーハン・コーポレイション | ピロロ[2,3−c]ピリジン誘導体及びその製造方法 |
WO2009061730A2 (en) | 2007-11-05 | 2009-05-14 | Array Biopharma Inc. | 4-heteroaryl-substituted phenoxyphenylacetic acid |
-
2013
- 2013-07-29 BG BG111544A patent/BG111544A/bg unknown
-
2014
- 2014-07-11 US US14/904,893 patent/US9738640B2/en active Active
- 2014-07-11 WO PCT/BG2014/000027 patent/WO2015013777A2/en active Application Filing
- 2014-07-11 EP EP14831149.1A patent/EP2991986B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2991986B1 (en) | 2017-03-08 |
US9738640B2 (en) | 2017-08-22 |
WO2015013777A2 (en) | 2015-02-05 |
WO2015013777A9 (en) | 2015-11-19 |
WO2015013777A3 (en) | 2016-01-14 |
EP2991986A2 (en) | 2016-03-09 |
US20160152611A1 (en) | 2016-06-02 |
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