PL398731A3 - Inhibitory cholinoesteraz o strukturze hybrydowej - Google Patents
Inhibitory cholinoesteraz o strukturze hybrydowejInfo
- Publication number
- PL398731A3 PL398731A3 PL398731A PL39873112A PL398731A3 PL 398731 A3 PL398731 A3 PL 398731A3 PL 398731 A PL398731 A PL 398731A PL 39873112 A PL39873112 A PL 39873112A PL 398731 A3 PL398731 A3 PL 398731A3
- Authority
- PL
- Poland
- Prior art keywords
- cholinesterase inhibitors
- hybrid structure
- formula
- group
- inhibition
- Prior art date
Links
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 102100033639 Acetylcholinesterase Human genes 0.000 abstract 1
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract 1
- 108010053652 Butyrylcholinesterase Proteins 0.000 abstract 1
- 102100032404 Cholinesterase Human genes 0.000 abstract 1
- 229940022698 acetylcholinesterase Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inhibitory cholinoesteraz o strukturze hybrydowej przedstawione wzorem ogólnym (I), w którym A oznacza grupe C9-C14-alkilowa, R1 i R2 sa takie same lub rózne i niezaleznie od siebie oznaczaja atom wodoru, atom fluorowca, grupe C1-C3-alkilowa ewentualnie podstawiona atomami fluorowca lub grupe C1-C3-alkoksylowa, a X oznacza grupe o wzorze (A), oraz ich farmaceutycznie dopuszczalne sole charakteryzuja sie wysoka selektywnoscia hamowania acetylocholinesterazy wzgledem hamowania butyrylocholinoesterazy i stanowia potencjalne leki do zapobiegania i/lub leczenia zaburzen neurodegeneracyjnych, w tym choroby Alzheimera. Wynalazek obejmuje takze sposób wytwarzania inhibitorów cholinoesteraz przedstawionych wzorem (I).
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL398731A PL221154B1 (pl) | 2012-04-04 | 2012-04-04 | Inhibitory cholinoesteraz o strukturze hybrydowej, sposób ich otrzymywania, ich zastosowanie oraz preparat farmaceutyczny je zawierający |
| PL12730282T PL2714658T3 (pl) | 2011-06-03 | 2012-05-29 | Nowe inhibitory cholinoesteraz o strukturze hybrydowej |
| EP20120730282 EP2714658B1 (en) | 2011-06-03 | 2012-05-29 | Novel hybrid cholinesterase inhibitors |
| PCT/PL2012/000038 WO2012165981A1 (en) | 2011-06-03 | 2012-05-29 | Novel hybrid cholinesterase inhibitors |
| ES12730282.6T ES2539178T3 (es) | 2011-06-03 | 2012-05-29 | Nuevos inhibidores híbridos de colinesterasa |
| US14/087,744 US8841453B2 (en) | 2011-06-03 | 2013-11-22 | Hybrid cholinesterase inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL398731A PL221154B1 (pl) | 2012-04-04 | 2012-04-04 | Inhibitory cholinoesteraz o strukturze hybrydowej, sposób ich otrzymywania, ich zastosowanie oraz preparat farmaceutyczny je zawierający |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL398731A3 true PL398731A3 (pl) | 2013-10-14 |
| PL221154B1 PL221154B1 (pl) | 2016-02-29 |
Family
ID=49304570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL398731A PL221154B1 (pl) | 2011-06-03 | 2012-04-04 | Inhibitory cholinoesteraz o strukturze hybrydowej, sposób ich otrzymywania, ich zastosowanie oraz preparat farmaceutyczny je zawierający |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL221154B1 (pl) |
-
2012
- 2012-04-04 PL PL398731A patent/PL221154B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL221154B1 (pl) | 2016-02-29 |
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