MX2013002956A - Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central. - Google Patents

Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central.

Info

Publication number
MX2013002956A
MX2013002956A MX2013002956A MX2013002956A MX2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A MX 2013002956 A MX2013002956 A MX 2013002956A
Authority
MX
Mexico
Prior art keywords
treatment
arylosulfonamides
cns diseases
disorders
prevention
Prior art date
Application number
MX2013002956A
Other languages
English (en)
Inventor
Marcin Kolaczkowski
Piotr Kowalski
Jolanta Jaskowska
Monika Marcinkowski
Kayarzyna Mitka
Adam Bucki
Anna Wesolowska
Maciej Pawlowski
Original Assignee
Adamed Sp Zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adamed Sp Zoo filed Critical Adamed Sp Zoo
Publication of MX2013002956A publication Critical patent/MX2013002956A/es

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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  • Plural Heterocyclic Compounds (AREA)
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  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
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Abstract

Derivados de arilsulfonamida de la fórmula (I) y sales farmacéuticamente aceptables de los mismos; los compuestos pueden ser útiles para el tratamiento y/o prevención de trastornos del sistema nervioso central.
MX2013002956A 2010-09-17 2011-09-16 Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central. MX2013002956A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL39243610A PL392436A1 (pl) 2010-09-17 2010-09-17 Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego
PCT/EP2011/066054 WO2012035123A1 (en) 2010-09-17 2011-09-16 Arylosulfonamides for the treatment of cns diseases

Publications (1)

Publication Number Publication Date
MX2013002956A true MX2013002956A (es) 2013-05-09

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Application Number Title Priority Date Filing Date
MX2013002956A MX2013002956A (es) 2010-09-17 2011-09-16 Arilsulfonamidas para el tratamiento de enfermedades del sistema nervioso central.

Country Status (15)

Country Link
US (2) US8822517B2 (es)
EP (1) EP2616440A1 (es)
JP (1) JP5899218B2 (es)
KR (1) KR20130143569A (es)
CN (2) CN104529999A (es)
AU (1) AU2011303807B2 (es)
BR (1) BR112013006313A2 (es)
CA (1) CA2808246A1 (es)
EA (1) EA022776B1 (es)
MX (1) MX2013002956A (es)
NZ (1) NZ607031A (es)
PL (1) PL392436A1 (es)
UA (1) UA109793C2 (es)
WO (1) WO2012035123A1 (es)
ZA (2) ZA201302390B (es)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP3134392B1 (en) 2014-04-19 2019-01-02 Sunshine Lake Pharma Co., Ltd. Sulfonamide derivatives and pharmaceutical applications thereof
CN106749219A (zh) * 2015-11-20 2017-05-31 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
CN107602446B (zh) * 2016-07-12 2020-04-07 中国科学院上海药物研究所 1,4-双取代-1,2,3,6-四氢吡啶类化合物、其制备方法、药物组合物及其应用
MX2022007947A (es) * 2019-12-24 2022-07-27 Sumitomo Pharma Co Ltd Derivado de amida de acido alifatico.
KR102447231B1 (ko) * 2020-05-29 2022-09-27 재단법인 대구경북첨단의료산업진흥재단 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
WO2021241875A1 (ko) * 2020-05-29 2021-12-02 재단법인 대구경북첨단의료산업진흥재단 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2258843B1 (es) * 1974-01-30 1977-09-09 Roussel Uclaf
EP0190472B1 (en) 1984-12-21 1989-07-12 Duphar International Research B.V New pharmaceutical compositions having anti-psychotic properties
JP2556722B2 (ja) 1988-02-18 1996-11-20 興和株式会社 新規なスルホンアミド化合物
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
TWI242011B (en) * 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
GB9825413D0 (en) * 1998-11-19 1999-01-13 Lilly Co Eli Pharmaceutical compounds
GB9906624D0 (en) * 1999-03-23 1999-05-19 Smithkline Beecham Plc Novel compounds
PT1578740E (pt) * 2002-12-27 2007-05-31 Lundbeck & Co As H Derivados de 1, 2, 4-triaminobenzeno úteis para tratamento de distúrbios do sistema nervoso central
US7153858B2 (en) 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP2010519171A (ja) * 2006-02-17 2010-06-03 メモリー・ファーマシューティカルズ・コーポレイション ５−ｈｔ６受容体親和性を有する化合物

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CA2808246A1 (en) 2012-03-22
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US9120767B2 (en) 2015-09-01
JP2013540738A (ja) 2013-11-07
US20130172365A1 (en) 2013-07-04
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US8822517B2 (en) 2014-09-02
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PL392436A1 (pl) 2012-03-26
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NZ607031A (en) 2014-06-27
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