MX2020007265A - Derivados de rapamicina. - Google Patents

Derivados de rapamicina.

Info

Publication number
MX2020007265A
MX2020007265A MX2020007265A MX2020007265A MX2020007265A MX 2020007265 A MX2020007265 A MX 2020007265A MX 2020007265 A MX2020007265 A MX 2020007265A MX 2020007265 A MX2020007265 A MX 2020007265A MX 2020007265 A MX2020007265 A MX 2020007265A
Authority
MX
Mexico
Prior art keywords
compounds
rapamycin derivatives
compositions
formula
methods
Prior art date
Application number
MX2020007265A
Other languages
English (en)
Inventor
Michael Connolly
David Jonathan Glass
Simone Bonazzi
Manuel Mihalic
Andrew William Patterson
Silvio Roggo
Tea Shavlakadze
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2020007265A publication Critical patent/MX2020007265A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
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  • Hospice & Palliative Care (AREA)
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Abstract

La divulgación se refiere a compuestos de fórmula (I) y sus sales farmacéuticamente aceptables, y sus composiciones, en donde los sustituyentes son como se definen aquí. Además, se proporcionan métodos de preparación de compuestos de fórmula (I), y métodos que involucran los compuestos o las composiciones para el tratamiento de trastornos y enfermedades que se describen aquí. Fórmula (I). Ver Fórmula.
MX2020007265A 2017-09-26 2018-09-25 Derivados de rapamicina. MX2020007265A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762563312P 2017-09-26 2017-09-26
PCT/IB2018/057422 WO2019064182A1 (en) 2017-09-26 2018-09-25 RAPAMYCIN DERIVATIVES

Publications (1)

Publication Number Publication Date
MX2020007265A true MX2020007265A (es) 2020-09-18

Family

ID=63857991

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020007265A MX2020007265A (es) 2017-09-26 2018-09-25 Derivados de rapamicina.
MX2023001876A MX2023001876A (es) 2017-09-26 2020-07-13 Derivados de rapamicina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023001876A MX2023001876A (es) 2017-09-26 2020-07-13 Derivados de rapamicina.

Country Status (21)

Country Link
US (3) US10800793B2 (es)
EP (2) EP4365179A2 (es)
JP (2) JP7387590B2 (es)
KR (1) KR20200059219A (es)
CN (2) CN117417351A (es)
AR (1) AR112834A1 (es)
AU (1) AU2018342784B2 (es)
BR (1) BR112020005898A2 (es)
CA (1) CA3078191A1 (es)
DK (1) DK3687999T3 (es)
FI (1) FI3687999T3 (es)
HR (1) HRP20240199T1 (es)
LT (1) LT3687999T (es)
MX (2) MX2020007265A (es)
PL (1) PL3687999T3 (es)
PT (1) PT3687999T (es)
RS (1) RS65270B1 (es)
SI (1) SI3687999T1 (es)
TW (1) TW201920189A (es)
UY (1) UY37900A (es)
WO (1) WO2019064182A1 (es)

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US20220242878A1 (en) 2022-08-04
FI3687999T3 (fi) 2024-02-14
JP2023106500A (ja) 2023-08-01
EP3687999A1 (en) 2020-08-05
RU2020112056A3 (es) 2022-02-18
CN117417351A (zh) 2024-01-19
UY37900A (es) 2019-04-30
WO2019064182A1 (en) 2019-04-04
MX2023001876A (es) 2023-03-10
JP7387590B2 (ja) 2023-11-28
JP2020535134A (ja) 2020-12-03
US20200392159A1 (en) 2020-12-17
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PT3687999T (pt) 2024-02-12
DK3687999T3 (da) 2024-02-12
CN111094299B (zh) 2023-10-31
EP3687999B1 (en) 2024-01-03
US20190092788A1 (en) 2019-03-28
KR20200059219A (ko) 2020-05-28
CA3078191A1 (en) 2019-04-04
RU2020112056A (ru) 2021-10-28
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LT3687999T (lt) 2024-02-26
HRP20240199T1 (hr) 2024-04-26
PL3687999T3 (pl) 2024-05-06
EP4365179A2 (en) 2024-05-08
AU2018342784A1 (en) 2020-02-06
RS65270B1 (sr) 2024-03-29
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BR112020005898A2 (pt) 2020-11-17
AR112834A1 (es) 2019-12-18

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