MD4800B1 - Compuşi de aminopirimidinil ca inhibitori de JAK - Google Patents
Compuşi de aminopirimidinil ca inhibitori de JAKInfo
- Publication number
- MD4800B1 MD4800B1 MDA20170016A MD20170016A MD4800B1 MD 4800 B1 MD4800 B1 MD 4800B1 MD A20170016 A MDA20170016 A MD A20170016A MD 20170016 A MD20170016 A MD 20170016A MD 4800 B1 MD4800 B1 MD 4800B1
- Authority
- MD
- Moldova
- Prior art keywords
- compounds
- jak inhibitors
- aminopyrimidinyl
- aminopyrimidinyl compounds
- jak
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract
Invenţia se referă la compuşi de aminopirimidinil cu formula generală (I):(I),sau la sărurile farmaceutic acceptabile ale acestora, unde substituenţii sunt definiţi în descriere. De asemenea, sunt dezvăluite metode de tratament cu inhibitori ai Kinazei Janus (JAK), compoziţii farmaceutice ce conţin compuşii conform invenţiei şi combinaţii cu alţi agenţi terapeutici.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462039969P | 2014-08-21 | 2014-08-21 | |
PCT/IB2015/056021 WO2016027195A1 (en) | 2014-08-21 | 2015-08-07 | Aminopyrimidinyl compounds as jak inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20170016A2 MD20170016A2 (ro) | 2017-08-31 |
MD4800B1 true MD4800B1 (ro) | 2022-03-31 |
MD4800C1 MD4800C1 (ro) | 2022-10-31 |
Family
ID=54148580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20170016A MD4800C1 (ro) | 2014-08-21 | 2015-08-07 | Compuşi de aminopirimidinil ca inhibitori de JAK |
Country Status (48)
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2441873T3 (es) | 2005-05-26 | 2014-02-06 | Aldexa Therapeutics, Inc. | Derivados de quinolina para el tratamiento de enfermedades retinianas |
EP2948149A4 (en) | 2013-01-23 | 2016-12-14 | Aldeyra Therapeutics Inc | BY TOXIC ALDEHYDIC DISEASES AND TREATMENT |
US10138251B2 (en) | 2014-04-11 | 2018-11-27 | Boehringer Ingelheim International Gmbh | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors |
EP3164401B1 (en) | 2014-07-03 | 2018-12-26 | Boehringer Ingelheim International GmbH | New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors |
NO2721710T3 (ro) | 2014-08-21 | 2018-03-31 | ||
AR101600A1 (es) | 2014-08-21 | 2016-12-28 | Boehringer Ingelheim Int | COMPUESTOS DE SPIRO[3H-INDOL-3,2-PIRROLIDIN]-2(1H)-ONA Y DERIVADOS COMO INHIBIDORES DE MDM2-p53 |
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