EP4011865A4 - Bridged heterocyclyl-substituted pyrimidine compound, preparation method therefor, and pharmaceutical use thereof - Google Patents
Bridged heterocyclyl-substituted pyrimidine compound, preparation method therefor, and pharmaceutical use thereof Download PDFInfo
- Publication number
- EP4011865A4 EP4011865A4 EP20851903.3A EP20851903A EP4011865A4 EP 4011865 A4 EP4011865 A4 EP 4011865A4 EP 20851903 A EP20851903 A EP 20851903A EP 4011865 A4 EP4011865 A4 EP 4011865A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- preparation
- method therefor
- pharmaceutical use
- pyrimidine compound
- substituted pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title 1
- -1 pyrimidine compound Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910733723 | 2019-08-09 | ||
PCT/CN2020/107054 WO2021027647A1 (en) | 2019-08-09 | 2020-08-05 | Bridged heterocyclyl-substituted pyrimidine compound, preparation method therefor, and pharmaceutical use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4011865A1 EP4011865A1 (en) | 2022-06-15 |
EP4011865A4 true EP4011865A4 (en) | 2022-11-02 |
Family
ID=74570903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20851903.3A Pending EP4011865A4 (en) | 2019-08-09 | 2020-08-05 | Bridged heterocyclyl-substituted pyrimidine compound, preparation method therefor, and pharmaceutical use thereof |
Country Status (8)
Country | Link |
---|---|
US (1) | US20220348572A1 (en) |
EP (1) | EP4011865A4 (en) |
JP (1) | JP2022543690A (en) |
KR (1) | KR20220046593A (en) |
CN (1) | CN112654605B (en) |
AU (1) | AU2020328707A1 (en) |
CA (1) | CA3144420A1 (en) |
WO (1) | WO2021027647A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4279485A1 (en) * | 2021-01-14 | 2023-11-22 | The National Institutes of Pharmaceutical R&D Co., Ltd | Bridged heterocyclyl-substituted pyrimidine compounds, preparation method and medical use thereof |
CA3236262A1 (en) | 2021-10-25 | 2023-05-04 | Isaac Marx | Tyk2 degraders and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160052930A1 (en) * | 2014-08-21 | 2016-02-25 | Pfizer Inc. | Aminopyrimidinyl compounds |
CN110862376A (en) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | Small molecule compound |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2638018A1 (en) * | 2010-11-09 | 2013-09-18 | Cellzome Limited | Pyridine compounds and aza analogues thereof as tyk2 inhibitors |
KR20160046917A (en) * | 2013-09-03 | 2016-04-29 | 카나 바이오사이언스, 인코포레이션 | Novel 2,6-diaminopyrimidine derivative |
WO2017035366A1 (en) * | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
-
2020
- 2020-08-05 CN CN202080004748.2A patent/CN112654605B/en active Active
- 2020-08-05 WO PCT/CN2020/107054 patent/WO2021027647A1/en unknown
- 2020-08-05 KR KR1020227007091A patent/KR20220046593A/en unknown
- 2020-08-05 EP EP20851903.3A patent/EP4011865A4/en active Pending
- 2020-08-05 JP JP2022507868A patent/JP2022543690A/en active Pending
- 2020-08-05 US US17/633,089 patent/US20220348572A1/en active Pending
- 2020-08-05 CA CA3144420A patent/CA3144420A1/en active Pending
- 2020-08-05 AU AU2020328707A patent/AU2020328707A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160052930A1 (en) * | 2014-08-21 | 2016-02-25 | Pfizer Inc. | Aminopyrimidinyl compounds |
CN110862376A (en) * | 2019-10-24 | 2020-03-06 | 嘉兴特科罗生物科技有限公司 | Small molecule compound |
WO2021078021A1 (en) * | 2019-10-24 | 2021-04-29 | 嘉兴特科罗生物科技有限公司 | Small molecular compound |
Non-Patent Citations (2)
Title |
---|
FENSOME ET AL.: "Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)", J. MED. CHEM., vol. 61, no. 19, 11 October 2018 (2018-10-11), US, pages 8597 - 8612, XP055688622, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b00917 * |
See also references of WO2021027647A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN112654605B (en) | 2022-11-22 |
KR20220046593A (en) | 2022-04-14 |
TW202115036A (en) | 2021-04-16 |
AU2020328707A1 (en) | 2022-02-24 |
CA3144420A1 (en) | 2021-02-18 |
CN112654605A (en) | 2021-04-13 |
WO2021027647A1 (en) | 2021-02-18 |
JP2022543690A (en) | 2022-10-13 |
EP4011865A1 (en) | 2022-06-15 |
US20220348572A1 (en) | 2022-11-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3972967A4 (en) | Heterocyclic compounds, preparation methods and uses thereof | |
EP4077311A4 (en) | Heterocyclic compounds, preparation methods and uses thereof | |
EP3875458A4 (en) | Diphenyl-like compound, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and uses thereof | |
EP3889154A4 (en) | Heterocyclic compound intermediate, preparation method therefor and application thereof | |
EP3539963A4 (en) | Nitrogen-containing heterocyclic compound, preparation method, intermediate, pharmaceutical composition and use | |
EP3835296A4 (en) | Ketoamide compound and preparation method, pharmaceutical composition, and use thereof | |
EP4011886A4 (en) | Tetracyclic compound, preparation method therefor and use thereof | |
EP3991731A4 (en) | Pyrimidine five-membered nitrogen heterocyclic derivative, preparation method thereof and pharmaceutical use thereof | |
EP3290420A4 (en) | Pyrimidine pyrrole compound, preparation method therefor, pharmaceutical composition, and uses thereof | |
EP3424928A4 (en) | Nitrogenous heterocyclic compound, preparation method, intermediate, composition and use | |
EP3804847A4 (en) | Stable cerium-zirconium solid solution, preparation method therefor and use thereof | |
EP3580208A4 (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same | |
EP3640248A4 (en) | Aminopyrimidine compound, preparation method therefor and use thereof | |
EP4008719A4 (en) | Pyrazolone and pyrimidine compound, and preparation method and use therefor | |
EP3424929A4 (en) | Pyrimidine seven-membered-ring compounds, preparation method therefor, pharmaceutical composition thereof, and uses thereof | |
EP4039687A4 (en) | Tetracyclic pyrimidinone compound, preparation method therefor, and composition and use thereof | |
EP3670511A4 (en) | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | |
EP3556761A4 (en) | Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof | |
EP4082534A4 (en) | Solid preparation, and preparation method therefor and use thereof | |
EP3715342A4 (en) | Fluorosulfonyl-containing compound, intermediate thereof, preparation method therefor and use thereof | |
EP3643311A4 (en) | 4-oxo-alkylated tetramic acid compound, preparation method therefor and use thereof | |
EP3990445A4 (en) | Heterocyclic compounds, preparation methods therefor, and methods of uses thereof | |
EP3693358A4 (en) | Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof | |
EP4023659A4 (en) | Compound and drug conjugate, and preparation method and use thereof | |
EP3929198A4 (en) | Heterocyclic compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20220216 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20220929 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/506 20060101ALI20220923BHEP Ipc: A61P 37/00 20060101ALI20220923BHEP Ipc: A61P 35/00 20060101ALI20220923BHEP Ipc: C07D 471/08 20060101AFI20220923BHEP |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) |