PT3687999T - Derivados de rapamicina - Google Patents
Derivados de rapamicinaInfo
- Publication number
- PT3687999T PT3687999T PT187864087T PT18786408T PT3687999T PT 3687999 T PT3687999 T PT 3687999T PT 187864087 T PT187864087 T PT 187864087T PT 18786408 T PT18786408 T PT 18786408T PT 3687999 T PT3687999 T PT 3687999T
- Authority
- PT
- Portugal
- Prior art keywords
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762563312P | 2017-09-26 | 2017-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3687999T true PT3687999T (pt) | 2024-02-12 |
Family
ID=63857991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT187864087T PT3687999T (pt) | 2017-09-26 | 2018-09-25 | Derivados de rapamicina |
Country Status (23)
Country | Link |
---|---|
US (3) | US10800793B2 (pt) |
EP (2) | EP3687999B1 (pt) |
JP (2) | JP7387590B2 (pt) |
KR (1) | KR20200059219A (pt) |
CN (2) | CN117417351A (pt) |
AR (1) | AR112834A1 (pt) |
AU (1) | AU2018342784B2 (pt) |
BR (1) | BR112020005898A2 (pt) |
CA (1) | CA3078191A1 (pt) |
DK (1) | DK3687999T3 (pt) |
ES (1) | ES2973975T3 (pt) |
FI (1) | FI3687999T3 (pt) |
HR (1) | HRP20240199T1 (pt) |
HU (1) | HUE065692T2 (pt) |
LT (1) | LT3687999T (pt) |
MX (2) | MX2020007265A (pt) |
PL (1) | PL3687999T3 (pt) |
PT (1) | PT3687999T (pt) |
RS (1) | RS65270B1 (pt) |
SI (1) | SI3687999T1 (pt) |
TW (1) | TW201920189A (pt) |
UY (1) | UY37900A (pt) |
WO (1) | WO2019064182A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017136731A1 (en) | 2016-02-04 | 2017-08-10 | The Johns Hopkins University | Rapaglutins, novel inhibitors of glut and use thereof |
ES2837484T3 (es) | 2016-02-04 | 2021-06-30 | Univ Johns Hopkins | Rapadocinas, inhibidores del transportador de nucleósidos equilibrativo 1 y usos de los mismos |
US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
HUE062352T2 (hu) * | 2018-05-01 | 2023-10-28 | Revolution Medicines Inc | C40-, C28- és C-32-helyzetekben kapcsolt rapamycin-analógok mint mTOR-inhibitorok |
IL278335B1 (en) | 2018-05-01 | 2024-05-01 | Revolution Medicines Inc | C26-linked rapamycin analogs as MTOR inhibitors |
WO2019241789A1 (en) | 2018-06-15 | 2019-12-19 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
CN118184678A (zh) | 2019-01-22 | 2024-06-14 | 艾奥维安制药公司 | Mtorc调节剂及其用途 |
KR102497821B1 (ko) * | 2019-08-23 | 2023-02-08 | 이화여자대학교 산학협력단 | 신규 mTOR 억제제 화합물 및 이의 용도 |
KR102486721B1 (ko) * | 2019-08-23 | 2023-01-10 | 이화여자대학교 산학협력단 | 신규 mTOR 억제제 화합물 및 이의 용도 |
TW202126323A (zh) * | 2019-10-01 | 2021-07-16 | 約翰斯赫普金斯大學 | 雷帕弗辛(Rapafucin)衍生化合物及其使用方法 |
CA3163680A1 (en) | 2019-12-05 | 2021-06-10 | David John O'neill | Rapamycin analogs and uses thereof |
DE102020203224A1 (de) | 2020-03-12 | 2021-09-16 | Heinrich-Heine-Universität Düsseldorf | Inhibition von FKBP1A zur Therapie des Triple-negativen Mammakarzinoms |
US20230133761A1 (en) | 2020-03-12 | 2023-05-04 | Heinrich-Heine-Universität Düsseldorf | Inhibition of fkbp1a for the treatment of triple-negative mammary carcinoma |
KR20230084095A (ko) * | 2020-03-27 | 2023-06-12 | 에오비안 파마슈티컬스, 인크. | Mtorc1 조절제 및 이의 용도 |
WO2022033529A1 (zh) * | 2020-08-12 | 2022-02-17 | 洪明奇 | Sema3d拮抗剂在预防或治疗神经退行性疾病以及延长寿命中的用途 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
CA2219080A1 (en) | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamycin-based regulation of biological events |
PT833828E (pt) * | 1995-06-09 | 2003-02-28 | Novartis Ag | Derivados de rapamicina |
GB9606452D0 (en) | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
CA2318402A1 (en) | 1998-01-15 | 1999-07-22 | Ariad Gene Therapeutics, Inc. | Regulation of biological events using multimeric chimeric proteins |
WO2001014387A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
GB0504994D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
GB0601406D0 (en) | 2006-01-24 | 2006-03-08 | Novartis Ag | Organic Compounds |
US20090023768A1 (en) * | 2006-02-24 | 2009-01-22 | Novartis Ag | Rapamycin derivatives for treating neuroblastoma |
WO2008022256A2 (en) | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
GB0911888D0 (en) * | 2009-07-08 | 2009-08-19 | Oxford Biodynamics Ltd | Method of treating age related disorders |
WO2011123524A2 (en) * | 2010-03-31 | 2011-10-06 | Auspex Pharmaceutical, Inc. | Macrolide inhibitors of mtor |
US8906374B2 (en) | 2010-04-20 | 2014-12-09 | Cedars-Sinai Medical Center | Combination therapy with CD4 lymphocyte depletion and mTOR inhibitors |
EP2670758B1 (en) | 2011-02-04 | 2022-09-28 | Synthon BV | Process for making trisubstituted silyloxyethyl triflates |
ES2570183T3 (es) | 2011-02-16 | 2016-05-17 | Novartis Ag | Combinaciones de agentes terapéuticos para uso en el tratamiento de enfermedades neurodegenerativas |
CA2856803A1 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
WO2017044720A1 (en) * | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
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2018
- 2018-09-24 AR ARP180102741A patent/AR112834A1/es unknown
- 2018-09-24 UY UY0001037900A patent/UY37900A/es not_active Application Discontinuation
- 2018-09-25 CA CA3078191A patent/CA3078191A1/en active Pending
- 2018-09-25 US US16/141,856 patent/US10800793B2/en active Active
- 2018-09-25 HR HRP20240199TT patent/HRP20240199T1/hr unknown
- 2018-09-25 CN CN202311329093.8A patent/CN117417351A/zh active Pending
- 2018-09-25 CN CN201880057805.6A patent/CN111094299B/zh active Active
- 2018-09-25 BR BR112020005898-0A patent/BR112020005898A2/pt unknown
- 2018-09-25 HU HUE18786408A patent/HUE065692T2/hu unknown
- 2018-09-25 SI SI201831063T patent/SI3687999T1/sl unknown
- 2018-09-25 LT LTEPPCT/IB2018/057422T patent/LT3687999T/lt unknown
- 2018-09-25 TW TW107133541A patent/TW201920189A/zh unknown
- 2018-09-25 FI FIEP18786408.7T patent/FI3687999T3/fi active
- 2018-09-25 MX MX2020007265A patent/MX2020007265A/es unknown
- 2018-09-25 DK DK18786408.7T patent/DK3687999T3/da active
- 2018-09-25 KR KR1020207007749A patent/KR20200059219A/ko not_active Application Discontinuation
- 2018-09-25 WO PCT/IB2018/057422 patent/WO2019064182A1/en active Application Filing
- 2018-09-25 RS RS20240184A patent/RS65270B1/sr unknown
- 2018-09-25 EP EP18786408.7A patent/EP3687999B1/en active Active
- 2018-09-25 PL PL18786408.7T patent/PL3687999T3/pl unknown
- 2018-09-25 PT PT187864087T patent/PT3687999T/pt unknown
- 2018-09-25 JP JP2020516599A patent/JP7387590B2/ja active Active
- 2018-09-25 EP EP24150040.4A patent/EP4365179A3/en active Pending
- 2018-09-25 AU AU2018342784A patent/AU2018342784B2/en active Active
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2020
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- 2020-08-27 US US17/004,434 patent/US20200392159A1/en not_active Abandoned
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2021
- 2021-10-12 US US17/499,433 patent/US20220242878A1/en active Pending
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2023
- 2023-05-18 JP JP2023081938A patent/JP2023106500A/ja active Pending
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