JO3398B1 - مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي - Google Patents
مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيديInfo
- Publication number
- JO3398B1 JO3398B1 JOP/2012/0388A JOP20120388A JO3398B1 JO 3398 B1 JO3398 B1 JO 3398B1 JO P20120388 A JOP20120388 A JO P20120388A JO 3398 B1 JO3398 B1 JO 3398B1
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- dihydro
- benzo
- treatment
- pi3k
- phosphoinositide
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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Abstract
يتعلق الاختراع بمركبات ثانى هيدرو- بنزو- أوكسازين وثانى هيدرو- بيريدو- أوكسازين بالصيغة (I) و/أو أملاح مقبولة صيدلياً و/أو منذابات منها، حيث تكون Y, V, W, U, Q, R1, R5, R7 وR30 كما هى معرفة فى الوصف. تعتبر هذه المركبات مناسبة لعلاج اضطراب أو مرض والذى يكون متوسط بنشاط إنزيمات PI3K.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201161579231P | 2011-12-22 | 2011-12-22 |
Publications (1)
Publication Number | Publication Date |
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JO3398B1 true JO3398B1 (ar) | 2019-10-20 |
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ID=47678928
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Application Number | Title | Priority Date | Filing Date |
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JOP/2012/0388A JO3398B1 (ar) | 2011-12-22 | 2012-12-20 | مشتقات 2،3- ثانى هيدرو- بنزو[1,4] أوكسازين والمركبات المتعلقة بها كمثبطات كيناز فسفواينوسيتيد-3 (pi3k) لمعالجة على سبيل المثال التهاب المفاصل الروماتيدي |
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