SG10201805392YA - 1,2,4-triazine-6-carboxamide kinase inhibitors - Google Patents

1,2,4-triazine-6-carboxamide kinase inhibitors

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Publication number
SG10201805392YA
SG10201805392YA SG10201805392YA SG10201805392YA SG10201805392YA SG 10201805392Y A SG10201805392Y A SG 10201805392YA SG 10201805392Y A SG10201805392Y A SG 10201805392YA SG 10201805392Y A SG10201805392Y A SG 10201805392YA SG 10201805392Y A SG10201805392Y A SG 10201805392YA
Authority
SG
Singapore
Prior art keywords
triazine
carboxamide
kinase inhibitors
methods
syk kinase
Prior art date
Application number
SG10201805392YA
Inventor
Zhaozhong J Jia
Brian Kane
Jack Rose
Shawn M Bauer
Yonghong Song
Qing Xu
Anjali Pandey
Original Assignee
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Publication of SG10201805392YA publication Critical patent/SG10201805392YA/en

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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

1,2,4-TRIAZINE-6-CARBOXAMIDE KINASE INHIBITORS Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity. No Figure
SG10201805392YA 2012-06-22 2013-06-14 1,2,4-triazine-6-carboxamide kinase inhibitors SG10201805392YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261663499P 2012-06-22 2012-06-22
US13/841,472 US9040530B2 (en) 2012-06-22 2013-03-15 1,2,4-triazine-6-carboxamide kinase inhibitors

Publications (1)

Publication Number Publication Date
SG10201805392YA true SG10201805392YA (en) 2018-08-30

Family

ID=49769666

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SG10201805392YA SG10201805392YA (en) 2012-06-22 2013-06-14 1,2,4-triazine-6-carboxamide kinase inhibitors
SG11201408232RA SG11201408232RA (en) 2012-06-22 2013-06-14 1,2,4-triazine-6-carboxamide kinase inhibitors

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SG11201408232RA SG11201408232RA (en) 2012-06-22 2013-06-14 1,2,4-triazine-6-carboxamide kinase inhibitors

Country Status (12)

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US (1) US9040530B2 (en)
EP (1) EP2863748B1 (en)
JP (1) JP6281984B2 (en)
CN (1) CN104470363A (en)
AU (1) AU2013277476B2 (en)
CA (1) CA2876945C (en)
HK (1) HK1209277A1 (en)
IL (1) IL236057B (en)
IN (1) IN2014KN02906A (en)
SG (2) SG10201805392YA (en)
WO (1) WO2013192049A2 (en)
ZA (1) ZA201409256B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2762476A4 (en) * 2011-09-30 2015-03-25 Taiho Pharmaceutical Co Ltd 1,2,4-triazine-6-carboxamide derivative
RU2015116532A (en) 2012-10-19 2016-12-10 Ф. Хоффманн-Ля Рош Аг SYK TYROSINKINASE INHIBITORS
EP4071144A1 (en) 2012-11-08 2022-10-12 Bristol-Myers Squibb Company Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
WO2014109414A1 (en) * 2013-01-11 2014-07-17 富士フイルム株式会社 Nitrogen-containing heterocylic compound or salt thereof
CN104870437A (en) * 2013-01-17 2015-08-26 四川恒康发展有限责任公司 Triazine compound, pharmaceutical salt, isomer, or hydrate thereof, and pharmaceutical composition thereof
JP2016113366A (en) * 2013-03-29 2016-06-23 大鵬薬品工業株式会社 1,2,4-triazine-6-carboxamide derivative with acetamide group
WO2015084998A1 (en) 2013-12-05 2015-06-11 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
KR20180021740A (en) * 2015-06-02 2018-03-05 파마싸이클릭스 엘엘씨 Inhibitor of bruton tyrosine kinase
CN109384774B (en) * 2017-08-11 2023-02-17 中国科学院上海药物研究所 Polysubstituted pyrazine/triazine amide compounds and preparation method and application thereof
JP2022542704A (en) * 2019-08-01 2022-10-06 インテグラル バイオサイエンシーズ プライベート リミテッド Heterocyclic compounds and their use as kinase inhibitors
WO2021170046A1 (en) * 2020-02-26 2021-09-02 Beigene, Ltd. Tyk-2 inhibitor
WO2022032484A1 (en) * 2020-08-11 2022-02-17 北京诺诚健华医药科技有限公司 Pyridazine-3-formamide compound, and preparation method therefor and medical use thereof
WO2023108536A1 (en) * 2021-12-16 2023-06-22 Lynk Pharmaceuticals Co. Ltd. Tyk2 inhibitors and compositions and methods thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4622047B2 (en) * 1999-06-09 2011-02-02 アステラス製薬株式会社 Novel heterocyclic carboxamide derivatives
ATE288420T1 (en) * 1999-06-09 2005-02-15 Yamanouchi Pharma Co Ltd NOVEL HETEROCYCLIC CARBOXAMIDE DERIVATIVES
AU5108000A (en) 1999-06-10 2001-01-02 Yamanouchi Pharmaceutical Co., Ltd. Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
US7723336B2 (en) 2005-09-22 2010-05-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
KR20170051521A (en) * 2008-04-16 2017-05-11 포톨라 파마슈티컬스, 인코포레이티드 2,6-diamino-pyrimidin-5-yl-carboxamides as syk or jak kinases inhibitors
EP2762476A4 (en) * 2011-09-30 2015-03-25 Taiho Pharmaceutical Co Ltd 1,2,4-triazine-6-carboxamide derivative
UY34807A (en) * 2012-05-16 2013-12-31 Novartis Ag MONOCYCLIC DERIVATIVES OF HETEROARYL CYCLOALKYL-DIAMINE

Also Published As

Publication number Publication date
CA2876945C (en) 2021-07-27
AU2013277476B2 (en) 2016-12-15
ZA201409256B (en) 2019-09-25
JP6281984B2 (en) 2018-02-21
US9040530B2 (en) 2015-05-26
IL236057B (en) 2018-08-30
EP2863748B1 (en) 2018-11-07
EP2863748A4 (en) 2015-12-09
EP2863748A2 (en) 2015-04-29
HK1209277A1 (en) 2016-04-01
WO2013192049A3 (en) 2014-02-13
AU2013277476A1 (en) 2015-01-22
CN104470363A (en) 2015-03-25
IN2014KN02906A (en) 2015-05-08
US20130345191A1 (en) 2013-12-26
JP2015520232A (en) 2015-07-16
SG11201408232RA (en) 2015-01-29
WO2013192049A2 (en) 2013-12-27
IL236057A0 (en) 2015-02-01
CA2876945A1 (en) 2013-12-27

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