BR112015009395A2 - processo para preparação de derivados do ácido biliar - Google Patents
processo para preparação de derivados do ácido biliarInfo
- Publication number
- BR112015009395A2 BR112015009395A2 BR112015009395A BR112015009395A BR112015009395A2 BR 112015009395 A2 BR112015009395 A2 BR 112015009395A2 BR 112015009395 A BR112015009395 A BR 112015009395A BR 112015009395 A BR112015009395 A BR 112015009395A BR 112015009395 A2 BR112015009395 A2 BR 112015009395A2
- Authority
- BR
- Brazil
- Prior art keywords
- acid derivatives
- bile acid
- preparation
- preparing
- solvate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Abstract
resumo processo para preparação de derivados do ácido biliar a presente invenção refere-se a processos para a preparação de compostos da fórmula i: (i) ou de um sal ou um solvato farmaceuticamente aceitável do mesmo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718966P | 2012-10-26 | 2012-10-26 | |
| PCT/US2013/066917 WO2014066819A1 (en) | 2012-10-26 | 2013-10-25 | Process for preparing bile acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015009395A2 true BR112015009395A2 (pt) | 2017-07-04 |
Family
ID=50545344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015009395A BR112015009395A2 (pt) | 2012-10-26 | 2013-10-25 | processo para preparação de derivados do ácido biliar |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9777038B2 (pt) |
| EP (1) | EP2912013B1 (pt) |
| JP (1) | JP6272888B2 (pt) |
| KR (1) | KR102068381B1 (pt) |
| CN (2) | CN108250264A (pt) |
| AU (1) | AU2013334122B2 (pt) |
| BR (1) | BR112015009395A2 (pt) |
| CA (1) | CA2889592A1 (pt) |
| CY (1) | CY1119731T1 (pt) |
| DK (1) | DK2912013T3 (pt) |
| ES (1) | ES2655034T3 (pt) |
| HK (2) | HK1253301A1 (pt) |
| HU (1) | HUE036887T2 (pt) |
| IL (1) | IL238454B (pt) |
| MX (1) | MX361653B (pt) |
| NO (1) | NO2968302T3 (pt) |
| NZ (2) | NZ707389A (pt) |
| PL (1) | PL2912013T3 (pt) |
| PT (1) | PT2912013T (pt) |
| SG (1) | SG11201503247UA (pt) |
| WO (1) | WO2014066819A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201503247UA (en) | 2012-10-26 | 2015-06-29 | Intercept Pharmaceuticals Inc | Process for preparing bile acid derivatives |
| EP3149019B1 (en) * | 2014-05-29 | 2019-12-04 | Bar Pharmaceuticals S.r.l. | Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases |
| KR102526632B1 (ko) | 2014-11-19 | 2023-04-27 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 5β-6-알킬-7-하이드록시-3-온 스테로이드 |
| EP3221334B1 (en) | 2014-11-19 | 2020-02-19 | Nzp Uk Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| CN107207559B (zh) | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| TWI686401B (zh) | 2014-11-19 | 2020-03-01 | 英商Ｎｚｐ英國有限公司 | 化合物（三） |
| CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
| CA2976056C (en) | 2015-02-06 | 2024-02-06 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions for combination therapy |
| AU2016325619A1 (en) * | 2015-09-24 | 2018-04-12 | Intercept Pharmaceuticals, Inc. | Methods and intermediates for the preparation bile acid derivatives |
| AU2016350690C1 (en) * | 2015-11-06 | 2020-04-23 | Intercept Pharmaceuticals, Inc. | Methods for the preparation of obeticholic acid and derivatives thereof |
| WO2017142895A1 (en) * | 2016-02-15 | 2017-08-24 | Regents Of The University Of Minnesota | Compositions and methods for treating clostridium associated diseases |
| JP6968821B2 (ja) | 2016-04-13 | 2021-11-17 | インターセプト ファーマシューティカルズ， インコーポレイテッド | 癌を治療する方法 |
| TW201738254A (zh) * | 2016-04-19 | 2017-11-01 | 英特賽普醫藥品公司 | 奧貝膽酸及其衍生物之製備方法 |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| KR20190057108A (ko) * | 2016-09-30 | 2019-05-27 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 유도체의 결정형 |
| MX2020000873A (es) | 2017-07-24 | 2020-07-22 | Intercept Pharmaceuticals Inc | Derivados de ácidos biliares marcados isotópicamente. |
| JP7308811B2 (ja) | 2017-07-26 | 2023-07-14 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | ステロイド系誘導体ｆｘｒアゴニストの製造方法 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| KR20220016146A (ko) | 2019-05-30 | 2022-02-08 | 인터셉트 파마슈티컬즈, 인크. | 담즙정체성 간 질환의 치료에서 사용하기 위한 fxr 효능제 및 피브레이트를 포함하는 제약 조성물 |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| EP4215540A1 (en) | 2020-09-18 | 2023-07-26 | Seoul National University R & DB Foundation | Method for mass-producing sodium taurodeoxycholate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216015A (en) * | 1991-02-05 | 1993-06-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having hypocholesterolemic properties |
| USRE48286E1 (en) * | 2001-03-12 | 2020-10-27 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for FXR |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| WO2008002573A2 (en) * | 2006-06-27 | 2008-01-03 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| EP2303026B1 (en) * | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| WO2010014836A2 (en) * | 2008-07-30 | 2010-02-04 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| CN106380502A (zh) * | 2008-11-19 | 2017-02-08 | 英特塞普特医药品公司 | G蛋白偶联受体5(tgr5)调节剂及其使用方法 |
| SG11201503247UA (en) | 2012-10-26 | 2015-06-29 | Intercept Pharmaceuticals Inc | Process for preparing bile acid derivatives |
-
2013
- 2013-10-25 SG SG11201503247UA patent/SG11201503247UA/en unknown
- 2013-10-25 US US14/438,323 patent/US9777038B2/en active Active
- 2013-10-25 EP EP13849263.2A patent/EP2912013B1/en active Active
- 2013-10-25 NZ NZ707389A patent/NZ707389A/en not_active IP Right Cessation
- 2013-10-25 JP JP2015539862A patent/JP6272888B2/ja not_active Expired - Fee Related
- 2013-10-25 ES ES13849263.2T patent/ES2655034T3/es active Active
- 2013-10-25 DK DK13849263.2T patent/DK2912013T3/en active
- 2013-10-25 AU AU2013334122A patent/AU2013334122B2/en not_active Ceased
- 2013-10-25 CN CN201810282054.XA patent/CN108250264A/zh active Pending
- 2013-10-25 CA CA2889592A patent/CA2889592A1/en not_active Abandoned
- 2013-10-25 BR BR112015009395A patent/BR112015009395A2/pt not_active Application Discontinuation
- 2013-10-25 PL PL13849263T patent/PL2912013T3/pl unknown
- 2013-10-25 PT PT138492632T patent/PT2912013T/pt unknown
- 2013-10-25 KR KR1020157012805A patent/KR102068381B1/ko active IP Right Grant
- 2013-10-25 HU HUE13849263A patent/HUE036887T2/hu unknown
- 2013-10-25 NZ NZ745013A patent/NZ745013A/en not_active IP Right Cessation
- 2013-10-25 MX MX2015005286A patent/MX361653B/es active IP Right Grant
- 2013-10-25 CN CN201380068062.XA patent/CN105102425B/zh not_active Expired - Fee Related
- 2013-10-25 WO PCT/US2013/066917 patent/WO2014066819A1/en active Application Filing
-
2014
- 2014-03-14 NO NO14725812A patent/NO2968302T3/no unknown
-
2015
- 2015-04-26 IL IL238454A patent/IL238454B/en active IP Right Grant
-
2016
- 2016-02-24 HK HK18112593.6A patent/HK1253301A1/zh unknown
- 2016-02-24 HK HK16102102.3A patent/HK1214239A1/zh not_active IP Right Cessation
-
2017
- 2017-08-21 US US15/681,609 patent/US10202414B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 CY CY20181100003T patent/CY1119731T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |