NO2968302T3 - - Google Patents

Info

Publication number
NO2968302T3
NO2968302T3 NO14725812A NO14725812A NO2968302T3 NO 2968302 T3 NO2968302 T3 NO 2968302T3 NO 14725812 A NO14725812 A NO 14725812A NO 14725812 A NO14725812 A NO 14725812A NO 2968302 T3 NO2968302 T3 NO 2968302T3
Authority
NO
Norway
Application number
NO14725812A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO2968302T3 publication Critical patent/NO2968302T3/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO14725812A 2012-10-26 2014-03-14 NO2968302T3 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26

Publications (1)

Publication Number Publication Date
NO2968302T3 true NO2968302T3 (pt) 2018-02-03

Family

ID=50545344

Family Applications (1)

Application Number Title Priority Date Filing Date
NO14725812A NO2968302T3 (pt) 2012-10-26 2014-03-14

Country Status (21)

Country Link
US (2) US9777038B2 (pt)
EP (1) EP2912013B1 (pt)
JP (1) JP6272888B2 (pt)
KR (1) KR102068381B1 (pt)
CN (2) CN108250264A (pt)
AU (1) AU2013334122B2 (pt)
BR (1) BR112015009395A2 (pt)
CA (1) CA2889592A1 (pt)
CY (1) CY1119731T1 (pt)
DK (1) DK2912013T3 (pt)
ES (1) ES2655034T3 (pt)
HK (2) HK1214239A1 (pt)
HU (1) HUE036887T2 (pt)
IL (1) IL238454B (pt)
MX (1) MX361653B (pt)
NO (1) NO2968302T3 (pt)
NZ (2) NZ745013A (pt)
PL (1) PL2912013T3 (pt)
PT (1) PT2912013T (pt)
SG (1) SG11201503247UA (pt)
WO (1) WO2014066819A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2912013B1 (en) 2012-10-26 2017-10-11 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
ES2768718T3 (es) 2014-05-29 2020-06-23 Bar Pharmaceuticals S R L Derivados de colano para su uso en el tratamiento y/o prevención de enfermedades mediadas por FXR y TGR5/GPBAR1
KR102527821B1 (ko) 2014-11-19 2023-05-02 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드
DK3221333T3 (da) 2014-11-19 2019-09-30 Nzp Uk Ltd 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
EA033427B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
US11311557B2 (en) 2015-02-06 2022-04-26 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions for combination therapy
JP2018528230A (ja) * 2015-09-24 2018-09-27 インターセプト ファーマシューティカルズ, インコーポレイテッド 胆汁酸誘導体の調製のための方法および中間体
KR20180067699A (ko) * 2015-11-06 2018-06-20 인터셉트 파마슈티컬즈, 인크. 오베티콜산 및 이의 유도체의 제조 방법
WO2017142895A1 (en) * 2016-02-15 2017-08-24 Regents Of The University Of Minnesota Compositions and methods for treating clostridium associated diseases
CN109071452A (zh) 2016-04-13 2018-12-21 英特塞普特医药品公司 治疗癌症的方法
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
WO2018064441A1 (en) * 2016-09-30 2018-04-05 Intercept Pharmaceuticals, Inc Crystalline forms of a bile acid derivative
CA3070837A1 (en) * 2017-07-24 2019-01-31 Intercept Pharmaceuticals, Inc. Isotopically labeled bile acid derivatives
JP7308811B2 (ja) * 2017-07-26 2023-07-14 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド ステロイド系誘導体fxrアゴニストの製造方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
BR112021024109A2 (pt) 2019-05-30 2022-03-22 Intercept Pharmaceuticals Inc Composições farmacêuticas compreendendo um agonista fxr e um fibrato para uso no tratamento de doença hepática colestática
AU2020363377A1 (en) 2019-10-07 2022-04-21 Kallyope, Inc. GPR119 agonists
IL298306A (en) 2020-05-19 2023-01-01 Kallyope Inc ampk operators
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators
JP2023542365A (ja) 2020-09-18 2023-10-06 ソウル大学校産学協力団 タウロデオキシコール酸ナトリウムの大量生産方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216015A (en) 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
CA2440680C (en) 2001-03-12 2010-06-01 Roberto Pellicciari Steroids as agonists for fxr
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
CA2656320C (en) 2006-06-27 2015-04-28 Intercept Pharmaceuticals, Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
US9943614B2 (en) 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
WO2010014836A2 (en) * 2008-07-30 2010-02-04 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
EP3150620B1 (en) * 2008-11-19 2020-01-08 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
EP2912013B1 (en) 2012-10-26 2017-10-11 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives

Also Published As

Publication number Publication date
PL2912013T3 (pl) 2018-05-30
EP2912013A4 (en) 2016-06-01
WO2014066819A1 (en) 2014-05-01
NZ745013A (en) 2019-08-30
IL238454B (en) 2018-11-29
CN108250264A (zh) 2018-07-06
ES2655034T3 (es) 2018-02-16
JP2015533852A (ja) 2015-11-26
MX361653B (es) 2018-12-13
US20150291653A1 (en) 2015-10-15
CN105102425A (zh) 2015-11-25
HK1253301A1 (zh) 2019-06-14
MX2015005286A (es) 2015-10-29
JP6272888B2 (ja) 2018-01-31
BR112015009395A2 (pt) 2017-07-04
EP2912013A1 (en) 2015-09-02
AU2013334122B2 (en) 2017-11-02
CN105102425B (zh) 2018-04-10
IL238454A0 (en) 2015-06-30
AU2013334122A1 (en) 2015-05-14
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
KR20150074062A (ko) 2015-07-01
SG11201503247UA (en) 2015-06-29
US20180079776A1 (en) 2018-03-22
US9777038B2 (en) 2017-10-03
EP2912013B1 (en) 2017-10-11
CY1119731T1 (el) 2018-06-27
CA2889592A1 (en) 2014-05-01
NZ707389A (en) 2018-08-31
KR102068381B1 (ko) 2020-01-20
US10202414B2 (en) 2019-02-12
DK2912013T3 (en) 2018-01-15
PT2912013T (pt) 2018-01-03

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